Lymphocyte and Immature Dendritic Cell Infiltrates in Differentiated, Poorly Differentiated, and Undifferentiated Thyroid Carcinoma

The immune system plays critical roles in tumor prevention, but also in its initiation and progression. Tumors are subjected to immunosurveillance, but cancer cells generate an immunosuppressive microenvironment that favors their escape from immune-mediated elimination. During chronic inflammation, immune cells can contribute to the formation and progression of tumors by producing mitogenic, prosurvival, proangiogenic and lymphangiogenic factors. Thyroid cancer is the most frequent type of endocrine neoplasia and is the most rapidly increasing cancer in the US. In this review, we discuss recent findings on how different immune cells and mediators can contribute to thyroid cancer development and progression.

show abstract

“…75 In contrast, a reduced or absent DC infiltration in PDTC and ATC was described in comparison to DTC. 76 TAMCs: Tumor-associated mast cells…”

Section: Dendritic Cells (Dcs)mentioning

confidence: 99%

The immune network in thyroid cancer

2016

View full text Add to dashboard Cite

show abstract

“…For instance, high T-regulatory cell density correlates with thyroid cancer aggressiveness, and an increased number of immunoregulatory natural killer cells has been demonstrated in PTC compared to normal tissues [39,40]. Furthermore, is has been shown that the degree of lymphocyte and immature dendritic cell infiltration correlated with better prognosis in PTC [41,42], whereas increased macrophage density in poorly differentiated thyroid carcinoma correlated with invasive features and worsened prognosis [43]. Jung et al found that tumor-associated macrophage density correlated with more aggressive subtypes, like anaplastic thyroid carcinoma [44].…”

Section: Tumor Metabolism and The Microenvironment In Thyroid Cancermentioning

confidence: 99%

Thyroid cancer metabolism: A review

Gill¹

2016

Thyroid Disorders Ther

View full text Add to dashboard Cite

Metabolic dysregulation within the tumor microenvironment (TME) is critical to the process of tumorigenesis in various cancer types. Thyrocyte metabolism in papillary and anaplastic thyroid cancer, however, remains poorly characterized, and studies analyzing the role of multicompartment metabolism in thyrocyte oncogenesis are sparse. We present a review of the current knowledge on cellular metabolism in non-cancerous and cancerous thyroid tissues, focusing on the monocarboxylate transporters MCT1 and MCT4, and on a transporter of the outer mitochondrial membrane TOMM20. Understanding the metabolic phenotype of tumor cells and associated stromal cells in thyroid cancer can have profound implications on the use of biomarker staining in detecting subclinical cancer, imaging as it relates to expression of various transport proteins, and therapeutic interventions that manipulate this dysregulated tumor metabolism to halt tumorigenesis and eradicate the cancer. Future studies are required to confirm the prognostic significance of these biomarkers and their correlation with existing staging schemas such as the AGES, AMES, ATA and MACIS scoring systems.

show abstract

“…DCs have also been proposed to participate in the development of thyroid cancer. In PTC rich DCs infiltrates were reported in all different histotypes [26]. DCs present a precise distribution in tumors; immature DCs are generally located within PTC nodules, while mature DCs are observed around tumor [31,34].…”

Section: Dendritic Cells (Dcs)mentioning

confidence: 97%

“…Nevertheless, higher prevalence of multifocal or bilateral lesions was reported in TC patients with coexisting CLTI [24] and recently Iliadou el al [25] showed that children and adolescents with CLTI presented more frequently familial PTC, even if no differences in outcome were found with respect to the presence of CLTI. In this regard, it should finally be noted that TC histotypes with a worse prognosis (PDTC, ATC) are characterized by a very reduced lymphocyte infiltration [26].…”

Section: Thyroid Cancer and Autoimmunity: Epidemiological And Clinicamentioning

confidence: 99%

Thyroid Autoimmunity and Cancer

Felicetti¹,

Catalano²,

Fortunati³

2017

Frontiers of Hormone Research

View full text Add to dashboard Cite

Cancer and autoimmune diseases are often associated in the same individual. The functional link between immune system and cancer development is only partially known. Even though the immune system can control the development of cancer through immune surveillance, cancer cell itself can escape immune surveillance. Actually, it is debated whether autoimmune diseases have to be regarded as cancer cause or its consequence.In particular, autoimmune thyroiditis and thyroid cancer (in particular, papillary thyroid cancer) are a fascinating model of this complex relationship. In the present review, we describe what has been reported by now in literature about autoimmune thyroiditis and papillary thyroid cancer, and on the basis of available data, we try to clarify the present knowledge.

show abstract

Lymphocyte and Immature Dendritic Cell Infiltrates in Differentiated, Poorly Differentiated, and Undifferentiated Thyroid Carcinoma

Cited by 82 publications

References 17 publications

The immune network in thyroid cancer

The immune network in thyroid cancer

Thyroid cancer metabolism: A review

Thyroid Autoimmunity and Cancer

Contact Info

Product

Resources

About