Lymphocutaneous Nocardia brasiliensis Infection Transmitted Via a Cat Scratch: A Second Case

Bottei, Edward; Flaherty, John P.; Kaplan, Leonard J.; Duffee-Kerr, Liane

doi:10.1093/clinids/18.4.649

Cited by 18 publications

(9 citation statements)

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“…In four cases in the literature, cats have been implicated in the transmission of N. brasiliensis 6–8 . To our knowledge, our case is the first report implicating a cat scratch in the transmission of N. asteroides .…”

mentioning

confidence: 64%

Cat scratch responsible for primary cutaneous Nocardia asteroides in an immunocompetent patient

Astudillo¹,

Dahan²,

Escourrou³

et al. 2001

Br J Dermatol

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mentioning

confidence: 64%

Cat scratch responsible for primary cutaneous Nocardia asteroides in an immunocompetent patient

Astudillo¹,

Dahan²,

Escourrou³

et al. 2001

Br J Dermatol

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“…Microorganisms of the genus Nocardia probably are not transmitted from person-to-person form [19], and the impact of infected domestic animals in transmission of the disease to humans remains unclear [3], although cutaneous-subcutaneous infections transmitted to people by bite or scratch wounds from cats have been described elsewhere [20,21]. Thus, precautions should be taken by humans affected by immune dysfunction, with special attention to avoid contact with soil or organic matter contaminated by domestic animals, and management of animals suspected of nocardiosis, particularly companion animals due to close contact with humans.…”

Section: Discussionmentioning

confidence: 99%

Uncommon mandibular osteomyelitis in a cat caused by Nocardia africana

et al. 2012

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BackgroundNocardiosis is an unusual infection in companion animals characterized by suppurative to pyogranulomatous lesions, localized or disseminated. Cutaneous-subcutaneous, pulmonary and systemic signs are observed in feline nocardiosis. However, osteomyelitis is a rare clinical manifestation in cats. Nocardia cyriacigeorgica (formerly N. asteroides sensu stricto), Nocardia brasiliensis, Nocardia otitidiscaviarum, and Nocardia nova are the most common pathogenic species identified in cats, based on recent molecular classification (16S rRNA gene). The present report is, to our knowledge, the first case of mandibular osteomyelitis in a cat caused by Nocardia africana, diagnosed based upon a combination of methods, including molecular techniques.Case presentationA one-year-old non-neutered female cat, raised in a rural area, was admitted to the Companion Animal Hospital-PUCPR, São José dos Pinhais, State of Paraná, Brazil, with a history a progressive facial lesion, difficulty apprehending food, loss of appetite, apathy and emaciation. Clinical examination showed fever, submandibular lymphadenitis, and a painless, 8 cm diameter mass, which was irregularly-shaped, of firm consistency, and located in the region of the left mandible. The skin around the lesion was friable, with diffuse inflammation (cellulitis), multiple draining sinuses, and exudation of serosanguinous material containing whitish “sulfur” granules.Diagnosis was based initially in clinical signs, microbiological culture, cytological, and histopathological findings, and radiographic images. Molecular sequencing of 16S rRNA of isolate allowed diagnosis of Nocardia africana. Despite supportive care and antimicrobial therapy based on in vitro susceptibility testing the animal died.ConclusionThe present report describes a rare clinical case of feline osteomyelitis caused by Nocardia africana, diagnosed based upon a combination of clinical signs, microbiological culture, cytological and histopathological findings, radiographic images, and molecular methods. The use of modern molecular techniques constitutes a quick and reliable method for Nocardia species identification, and may contribute to identification to new species of Nocardia that are virulent in cats.

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“…strains for human 1,6 . However, several cases of cutaneous-subcutaneous infections transmitted to people by bite or scratch from clinically health dogs and cats have been described 1,8,26,41 . Nocardia spp.…”

Section: Discussionmentioning

confidence: 99%

Nocardiosis: an overview and additional report of 28 cases in cattle and dogs

Ribeiro

Salerno

Mattos‐Guaraldi

et al. 2008

Rev. Inst. Med. trop. S. Paulo

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SUMMARYPhenotypic characteristics, antimicrobial susceptibility profile, and clinical-epidemiological features of 28 Nocardia strains isolated from 19 cases of bovine mastitis, eight cutaneous-subcutaneous lesions and one case of pneumonia in dogs were evaluated. Microbiological, biochemical, cytological and scanning electron microscopy methods were used in diagnosis. Nocardia asteroides type IV, Nocardia otitidiscaviarum, Nocardia nova (type III) and Nocardia farcinica (type V) were isolated from bovine milk, bronchial lavage and/or cutaneous-subcutaneous abscesses in dogs. Nocardial bovine mastitis was diagnosed predominantly in clinical cases, in dairy herds with poor environmental hygienic conditions between milking and inappropriate intramammary therapy. Canine nocardiosis was observed commonly in animals co-infected with distemper virus. Sulphamethoxazole-trimethoprim (92.8%), amikacin (92.8%) and ceftiofur (92.8%) were the most effective drugs in 28 isolates. Multiple drug resistance to three or more and five or more antimicrobials was observed in ten (35.7%) and three (10.7%) strains, respectively, predominantly with use of cloxaxillin, cefoperazone and ampicillin. The species (type) classification, clinical-epidemiological characteristics, diagnosis, multiple drug resistance and public health considerations in Nocardia strains isolated from cattle and dogs in Brazil are discussed, with special reference to report of bovine mastitis by N. otitidiscaviarum by first time in Brazil and the similarity between Nocardia species isolated from human and animal origin.

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Lymphocutaneous Nocardia brasiliensis Infection Transmitted Via a Cat Scratch: A Second Case

Cited by 18 publications

References 0 publications

Cat scratch responsible for primary cutaneous Nocardia asteroides in an immunocompetent patient

Cat scratch responsible for primary cutaneous Nocardia asteroides in an immunocompetent patient

Uncommon mandibular osteomyelitis in a cat caused by Nocardia africana

Nocardiosis: an overview and additional report of 28 cases in cattle and dogs

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