Lymphocele: a possible relationship with acute cellular rejection in kidney transplantation

Ma, Lipay; L, Noronha Ide; A, Vidonho Júnior; Je, Romão Júnior; Jc, Campagnari; Srougi, Miguel

doi:10.1590/s1516-31801999000600003

Cited by 21 publications

(10 citation statements)

References 8 publications

(12 reference statements)

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“…Significant association was found in the adult literature between lymphocele formation and diabetes, tacrolimus therapy, and acute rejection, but we could not confirm this in our pediatric cohort . Recent papers have demonstrated that recurrent acute rejection episodes are associated with the formation of lymphocele in adults . Acute rejection leads to an intense local inflammatory process, which may increase lymphatic leakage from the graft .…”

Section: Discussioncontrasting

confidence: 63%

Lymphocele after pediatric kidney transplantation: Incidence and risk factors

Giuliani

Gamba

Kiblawi

et al. 2014

Pediatric Transplantation

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Lymphocele is a well-known postoperative complication after kidney transplantation. The aim of this study was to analyze time trend incidence, risk factors, and outcome of post-transplant lymphocele in a large pediatric cohort. This is a retrospective single institution review of 241 pediatric kidney transplants performed from 2000 to 2013. Etiology of end-stage renal disease, recipient age and gender, transplant year, BMI percentile for age, type of dialysis, living/non-living related donor, acute rejection, and multiple transplantations were analyzed in association with lymphocele formation. Fourteen of 241 (5.81%) children developed a postoperative lymphocele. There has been a reduction in the incidence of lymphocele after 2006 (3.22% vs. 8.55%, p < 0.05). Significant risk factors for lymphocele were older age (≥11 yr), transplant before 2006, male gender, BMI percentile for age ≥95%, and multiple transplantations (p < 0.05). The one-yr graft survival was significantly reduced in the group with lymphocele compared with control (81.2% vs. 92.51%, p < 0.04). This is the first pediatric report showing the following risk factors associated with post-transplant lymphocele: age ≥11 yr, male gender, BMI for age ≥95%, and multiple transplantations. A lymphocele can contribute to graft loss in the first-year post-transplant.

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Section: Discussioncontrasting

confidence: 63%

Lymphocele after pediatric kidney transplantation: Incidence and risk factors

Giuliani

Gamba

Kiblawi

et al. 2014

Pediatric Transplantation

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“…Of 155 cases treated with sclerotherapy, 41 cases recurred, associated with an overall recurrence rate of 31% (95% CI: [23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39][40].…”

Section: Sclerotherapymentioning

confidence: 99%

Management of Primary Symptomatic Lymphocele After Kidney Transplantation: A Systematic Review

Lucewicz¹,

Wong²,

Lam³

et al. 2011

Transplantation

117

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Laparoscopic fenestration of a symptomatic lymphocele is associated with the lowest risk of lymphocele recurrence. However, the evidence base to support a recommendation for laparoscopic surgery as first line treatment is weak and highlights the need for a multicenter prospective cohort study to examine the benefits of incorporating initial simple aspiration into the management of lymphocele after kidney transplantation.

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“…In addition, Sansalone et al [10] reported a periallograft fluid collection associated with engraft enlargement as a common sign at ultrasonography during rejection episodes. Similarly, Lipay et al [15] described 84% of !1 acute rejection episode of patients with lymphocele. However, Ulrich et al [16], in a cohort of 426 renal allograft recipients, noted association between rejection, diabetes, and tacrolimus therapy on univariate analysis, but found only diabetes to be associated on multivariate analyses.…”

Section: Discussionmentioning

confidence: 90%