Lymphoblastic-like Leukemic Transformation of Polycythemia Vera

Polycythaemia rubra vera transforming to acute lymphoblastic leukaemia

“…To our knowledge there has been only one previous report of lymphoblastic transformation ofPRV (Hoffman et al 1978) and T-ALL following PRY has not previously been described. The development of lymphoblastic leukaemia in these two cases suggests that the prior phase of PRY may have originated in a common progenitor of myeloid, erythroid and lymphoid lineages.…”

Hairy Cell Leukemia in a Patient with Polycythemia Vera

“…The appearance of a lymphoproliféra tive disease during the course of a myelo proliferative disorder has been previously reported [3,4], The mechanism of this in terrelationship is unknown. It has been postulated that damage to primitive stem cells may be the cause.…”

Lymphoblastic leukemic transformation (lymphoblastic crisis) in myelofibrosis and myeloid metaplasia

“…Apart from CGL [ 1 1 ~ 22,47,48] , lymphoblastic leukemia in these patients is rare and a careful review of the literature revealed only one recent report of ALL occurring in a patient with PV [22] . However, in 1957, Videbaek and Poulsen [33] described a patient with MM who was found to have lymphosarcoma cell leukemia at postmortem which may, one might suppose in retrospect, have been ALL.…”

“…In contrast to CGL, lymphoblastic leukemia does not appear t o occur in other myeloproliferative disorders and t o the best of our knowledge only a single case developing in a patient with PV has been recorded [22] . However, rare examples of coincidental association of myelo-and lymphoproliferative disorders have been recorded [23][24][25]321 , while some patients with MF and MM may also develop what appears to be "lymphoma"…”