Lymphedema in a Patient with Stage IV Breast Cancer Due to Lymphatic Filariasis Diagnosed by Fine Needle Aspiration of an Axillary Lymph Node

Khan, Farhan; Charles, Aidan; Giwa, Bashirat; Naab, Tammey; Shokrani, Babak

doi:10.1093/ajcp/aqw165.009

Cited by 2 publications

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“…In some cases, it is associated with breast malignancy. [47] Although it is thought that coexistence of microfilariae and malignancy is co-incidental, yet some authors have suggested that such parasitic infestations may be a causative factor for tumorigenesis. [8]…”

Section: Discussionmentioning

confidence: 99%

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Microfilaria infection in metastatic node in a case of breast carcinoma

et al. 2019

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Filariasis is a major public health problem in tropical and subtropical countries such as India. It is caused by nematodes, principally Wuchereria bancrofti and Brugia malayi and is transmitted by the Culex mosquito. W.bancrofti accounts for 90% of cases of lymphatic filariasis. Filaria of the breast with axillary lymphadenopathy and lymphedema, mimicking breast carcinoma has been previously reported. Microfilariae have also been previously observed as coincidental findings with various inflammatory and neoplastic lesions. Few examples are hemangiomas of the liver, meningiomas, intracranial hemangioblastomas, uterine cervix, pharyngeal, urinary bladder, preputial and metastatic carcinomas, melanomas, and leukemia.Here, we report an unusual case of filarial infection of a metastatic axillary node in a case of invasive breast carcinoma, observed in a modified radical mastectomy specimen. Previous cases reported in literature have reported microfilaria in metastatic axillary node detected on cytology specimens; histological diagnosis, though reported, is rare.

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Section: Discussionmentioning

confidence: 99%

“…[2] Microfilariae have also been previously observed as coincidental findings of various neoplastic conditions. [3] Also, cytological evidence of lymphatic filariasis coexistent with breast carcinoma has been previously documented,[4] but histologically confirmed reports are still rare.…”

Section: Introductionmentioning

confidence: 99%

Microfilaria infection in metastatic node in a case of breast carcinoma

et al. 2019

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“…Risk factors for ASP in SSA may differ from that of HICs because of the very advanced stage at breast cancer diagnosis, different treatment courses or the broader environment including the physical burden in daily life or infectious agents [11][12][13]. In this setting, a substantial proportion of women do not receive timely, complete or high-quality treatment [14].…”

Section: Introductionmentioning

confidence: 99%

Self-reported arm and shoulder problems in breast cancer survivors in Sub-Saharan Africa: the African Breast Cancer-Disparities in Outcomes cohort study

et al. 2021

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Background Arm and shoulder problems (ASP), including lymphedema, were common among women with breast cancer in high-income countries before sentinel lymph node biopsy became the standard of care. Although ASP impair quality of life, as they affect daily life activities, their frequency and determinants in Sub-Saharan Africa remain unclear. Methods All women newly diagnosed with breast cancer at the Namibian, Ugandan, Nigerian, and Zambian sites of the African Breast Cancer-Disparities in Outcomes (ABC-DO) cohort study were included. At each 3-month follow-up interview, women answered the EORTC-QLQ-Br23 questionnaire, including three ASP items: shoulder/arm pain, arm stiffness, and arm/hand swelling. We estimated the cumulative incidence of first self-reported ASP, overall and stratified by study and treatment status, with deaths treated as competing events. To identify determinants of ASP, we estimated cause-specific hazard ratios using Cox models stratified by study site. Results Among 1476 women, up to 4 years after diagnosis, 43% (95% CI 40–46), 36% (33–38) and 23% (20–25), respectively, self-reported having experienced arm/shoulder pain, stiffness and arm/hand swelling at least once. Although risks of self-reported ASP differed between sites, a more advanced breast cancer stage at diagnosis, having a lower socioeconomic position and receiving treatment increased the risk of reporting an ASP. Conclusion ASP are very common in breast cancer survivors in Sub-Saharan Africa. They are influenced by different factors than those observed in high-income countries. There is a need to raise awareness and improve management of ASP within the African setting.

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Lymphedema in a Patient with Stage IV Breast Cancer Due to Lymphatic Filariasis Diagnosed by Fine Needle Aspiration of an Axillary Lymph Node

Cited by 2 publications

References 0 publications

Microfilaria infection in metastatic node in a case of breast carcinoma

Microfilaria infection in metastatic node in a case of breast carcinoma

Self-reported arm and shoulder problems in breast cancer survivors in Sub-Saharan Africa: the African Breast Cancer-Disparities in Outcomes cohort study

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