Lymphedema: Determining the Role of Angiogenesis

Kulungowski, Ann M.; Chawla, Aditya S.; Arany, Praveen; Fishman, Steven J.; Mulliken, John B.; Greene, Arin K.

doi:10.1097/01.prs.0000388842.51693.a8

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is suggested that the function and migration of Langerhans cells is disturbed with decreased Langerhans cells (LC) expression of MHC class II molecules in lymphedematous tissue and therefore antigen presentation in association with these molecules is impaired. Furthermore, only few LCs were found in the lymph nodes and their migration from the skin towards the lymphatics might be disrupted [7]. Furthermore, lymphedematous tissue has increased proangiogenic factors, specifically vascular endothelial growth factor, which influence skin carcinogenesis by altering growth and proliferation [8].…”

Section: Discussionmentioning

confidence: 99%

Synchronous non-collision melanoma and basal cell carcinoma arising from chronic lymphedema: a case report and review of literature

Sahned¹,

Jestila²,

Waheed³

et al. 2019

Journal of Surgical Case Reports

View full text Add to dashboard Cite

Chronic lymphedema (CL) due to failure of lymphatic drainage harbors an immunologically vulnerable environment for the development of various neoplasms. Independently, either melanoma or basal cell carcinoma (BCC) arising from CL has only been reported, but synchronous melanoma and BCC originating from CL is never reported. We report a very rare case of synchronous melanoma and BCC arising from the lymphedematous upper extremity developed secondary to axillary lymphadenectomy for breast cancer. Additionally, a literature review reporting either melanoma or BCC in the lymphedematous area was performed using Medline and PubMed databases.

show abstract

Section: Discussionmentioning

confidence: 99%