Lymphatic Uptake of Pulmonary Delivered Radiolabelled Solid Lipid Nanoparticles

Abstract

Results indicate that SLN could be effective colloidal carriers for lymphoscintigraphy or therapy upon pulmonary delivery.

Lung inflammation does not affect the clearance kinetics of lipid nanocapsules following pulmonary administration

“…administered dose crossing the air-blood barrier within the first 25 min post-administration (Fig. 3B) and a majority of the signal accumulating in the kidneys and bladder [27,28], from where it was eliminated within 24 h (Fig. 3C-D).…”

Nanomedicine in pulmonary delivery

“…Deposition and clearance of SLNs were assessed by Videira and colleagues 133,134 after inhalation of aerosolized insoluble particles using gamma-scintigraphy imaging analysis. It was observed that a few minutes after deposition, inhaled material began to translocate to regional lymph nodes indicating that inhalation can be an effective route to deliver drug-containing lipid partices to the lymphatic systems and lipid particles can be used as potential drug carriers for lung cancer therapy, as well as for vaccine delivery.…”

“…From these experiments, biodistribution of SLNs can be traced and evaluated. 133,134 Fluorescence/bioluminescence imaging systems for pulmonary gene delivery Visualization and evaluation of both the pulmonary delivery and the gene expression properties after dry powder inhalation in mice were recently reported by Mizuno and colleagues. 215 It was shown that the pulmonary delivery and Nanomedicine in pulmonary delivery Dovepress submit your manuscript | www.dovepress.com Dovepress the gene expression can be evaluated using fluorescence of indocyanine green (ICG) as a fluorescent label and the detection of luciferase activity, respectively, by using a nondestructive real-time in vivo imaging system.…”

Improving Nutrition Through the Design of Food Matrices

“…Finally, it is possible to control the physical location of a lipophilic component and to slow down molecular diffusion processes using conventional emulsions by crystallizing the lipid phase. These systems are known as solid lipid particle emulsions, which consist of emulsifier coated (partially) solid lipid particles dispersed in an aqueous continuous phase ( Figure 5) (Videira et al, 2002). By controlling the morphology of the crystalline lipid matrix it is possible to obtain more precise control over the release kinetics of functional compounds.…”