Lymphatic spreading pattern of intrahepatic cholangiocarcinoma

Tsuji, Tatsuya; Hiraoka, Takehisa; Kanemitsu, Keiichiro; Takahashi, Hiroshi; Tanabe, Dairo; Tashiro, Seiki

doi:10.1067/msy.2001.111873

Cited by 37 publications

(25 citation statements)

References 16 publications

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“…In addition, some authors harvested the lymph node along with the lesser omentum or left gastric artery for ICC originating from left lobe of the liver . According to the past literatures that evaluated the lymphatic spread of LNM with ICC, the spreading patterns were varied , and the presence of LNM in the undissected area might not have been considered at all in these articles. Furthermore, Jiang et al.…”

Section: Discussionmentioning

confidence: 99%

Lymph node dissection for intrahepatic cholangiocarcinoma: a critical review of the literature to date

Adachi

Eguchi

2013

J Hepato Biliary Pancreat

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Definite policy or evidence in regards to the lymph node dissection (LND) for intrahepatic cholangiocarcinoma (ICC) does not exist at present. We review and summarize the current knowledge about LND for ICC in reference to the literature to date. A Pubmed search was done to find the relevant literature. Only English literature from 2000 to 2013 was retrieved, using key words "intrahepatic cholangiocarcinoma" and "lymph node". In all selected articles, those which included a description of the difference in the survival results between the presence of lymph node metastasis (LNM), execution rate of LND, or institutional policy for LND were included in this review. In all reviewed articles, survival results of the LNM-positive group, evaluated by the 5-year survival rate, median survival time, or recurrence-free survival time were clearly worse than the LNM-negative group. However, the execution rate of LND was not often assessed, and therefore precise evaluation for the efficacy of LND is still controversial. Randomized controlled trials under the definite LND policy should be conducted to obtain precise survival results and clinical evaluation criteria for LND.

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Section: Discussionmentioning

confidence: 99%

Lymph node dissection for intrahepatic cholangiocarcinoma: a critical review of the literature to date

Adachi

Eguchi

2013

J Hepato Biliary Pancreat

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“…In hepatobiliary centres located in the Asian region with expertise in the treatment of ICC, routine lymphadenectomy around the hepatoduodenal ligament, peripancreatic nodes, coeliac trunk and lesser gastric curvature is commonly performed11, 18, a strategy that is often not followed in Western hospitals3. The need for more sensitive staging systems that take into account the prognostic value of lymph node involvement in ICC has been reported in the Asian literature16. Japanese surgical oncologists differentiate between certain tumour locations within the liver and the route of lymphatic spread.…”

Section: Discussionmentioning

confidence: 99%

Intramolecular Hydroamination with Homogeneous Zinc Catalysts: Evaluation of Substituent Effects in N,N′‐Disubstituted Aminotroponiminate Zinc Complexes

Dochnahl

Löhnwitz

Pissarek

et al. 2007

Chemistry A European J

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A series of symmetrical and unsymmetrical N,N'-disubstituted aminotroponimines (ATIHs) have been prepared. Substituents ranging from linear to cyclic alkyl groups, chelating ethers, and aryl groups were employed. The corresponding aminotroponiminate zinc complexes were then synthesized and characterized by a number of techniques, including by X-ray crystallography. Herein we report on the investigations into their activity in the intramolecular hydroamination of nonactivated alkenes. We also demonstrate that complexes bearing ligands with cyclic alkyl groups show superior activity in a number of selected reactions with functionalized aminoalkenes.

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“…It is well known that patients with lymph node‐positive tumours have a poor outcome. However, there is no solid evidence about the true value of lymphadenectomy for ICC10–18. This is in contrast to the situation for more common gastrointestinal cancers, such as stomach19 or colorectal cancer20, where lymphadenectomy has been proven to be beneficial.…”

Section: Introductionmentioning

confidence: 98%