Lymphatic recovery of exogenous oleic acid in rats on long chain or specific structured triacylglycerol diets

Abstract

Specific structured triacylglycerols, MLM (M = medium-chain fatty acid, L = long-chain fatty acid), rapidly deliver energy and long-chain fatty acids to the body and are used for longer periods in human enteral feeding. In the present study rats were fed diets of 10 wt% MLM or LLL (L = oleic acid [18:1 n-9], M = caprylic acid [8:01) for 2 wk. Then lymph was collected 24 h following administration of a single bolus of 13C-labeled MLM or LLL. The total lymphatic recovery of exogenous 18:1 n-9 24 h after administration of a single bolus of MLM or LLL was similar in rats on the LLL diet (43% and 45%, respectively). However, the recovery of exogenous 18:1 n-9 was higher after a single bolus of MLM compared with a bolus of LLL in rats on the MLM diet (40% and 24%, respectively, P = 0.009). The recovery of lymphatic 18:1 n-9 of the LLL bolus tended to depend on the diet triacylglycerol structure and composition (P= 0.07). This study demonstrated that with a diet containing specific structured triacylglycerol, the lymphatic recovery of 18:1 n-9 after a single bolus of fat was dependent on the triacylglycerol structure of the bolus. This indicates that the lymphatic recovery of long-chain fatty acids from a single meal depends on the overall long-chain fatty acid composition of the habitual diet. This could have implications for enteral feeding for longer periods.

Novel piperine-loaded Tween-integrated monoolein cubosomes as brain-targeted oral nanomedicine in Alzheimer’s disease: pharmaceutical, biological, and toxicological studies

“…Generally cubs containing GMO are proposed to be suitable candidates for lymphatic absorption 54 by-passing the hepatic first-pass effect. line except T-cubs (insignificant difference from negative control) (Table 4) showing superior effect over free drug and all other studied formulations.…”

Biotechnology in Future Food Lipids: Opportunities and Challenges

“…The medium-chain fatty acids at sn-1,3 positions could be hydrolyzed easier in the body than the long-chain fatty acids and thus could be utilized as a quick energy source (Ding et al 2009). Free medium-chain fatty acids have lower tendencies to be deposited in human adipose tissue (Nagao & Yanagita 2010, Vistisen et al 2006. Meanwhile, the remaining 2-MAGs with long-chain fatty acids still provide essential fatty acids and can be absorbed well through the intestinal wall.…”

Lipase-Catalyzed Interesterification for the Synthesis of Medium-Long-Medium (MLM) Structured Lipids

“…Vandenberghe et al ( 8 ) reported that both caprylic (C8:0) and capric acid (C10:0) are effective in increasing plasma ketones, and may potentially provide constant energy for the body. In addition, it has been reported that MCFA also have a weak tendency to accumulate in adipose tissue ( 6 , 9 – 11 ).…”