Lymphatic Pump OMT Releases Cytokines Into Central Circulation

Seffinger, Michael A.; Rich, Jessica D.

doi:10.7556/jaoa.2014.114

Cited by 4 publications

(4 citation statements)

References 4 publications

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“…Support for the efficiency of osteopathic treatments in neurodegenerative pathologies such as glaucoma, could be attributed to the positive influence that these treatments would have not only on the IOP but also on cerebral vascular perfusion, being then also capable of influencing venous, lymphatic and CSF circulation by facilitating its drainage [20][21][22][23][24][25][26][27][28][29][30][31][32][33][34][35].…”

Section: Discussionmentioning

confidence: 99%

“…The fact that bloodflow can also be lower in other parts of the body, and that the reduction in the flow of blood to the eye is often a precursor to glaucomatous damage, presupposes -as has also been shown by recent systematic revisions -that haemodynamic changes can be at least in part a primary factor in patients affected by glaucoma [8,9]. This hypothesis would explain the value of manipulative osteopathic treatment (OMth), including in other areas, not only the cervical-cranial area, aimed at an overall improvement in lymphatic drainage and vascular perfusion inside the cranium [20][21][22][23][24][25][26].…”

Section: Introduction and Aimsmentioning

confidence: 93%

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The Glymphatic System and New Etiopathogenic Hypotheses Concerning Glaucoma Based on Pilot Study on Glaucoma Patients Who Underwent Osteopathic Manipulative Treatment (OMT)

Paoli¹,

Michelin²,

Vassallo³

et al. 2022

BIJCROO

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Purpose Malfunction of the lymphatic or glymphatic system recently shown in the brain, seems to play an important role in central neurodegenerative pathologies through a build-up of neurotoxins. Recent studies have shown functional links between aqueous humour and cerebrospinal fluid via the glymphatic system, offering new perspectives and unifying theories on the vascular, biomechanical and biochemical causes of chronic and open angle glaucoma (POAG). The aim of this randomized pilot study is to compare the variations in intraocular pressure between 20 cases of compensated POAG under pharmacological therapy and 20 glaucoma patients undergoing osteopathic treatment, hypothesizing that this manipulation can influence intraocular pressure. Materials and Methods The 40 patients under study, all covered by the Helsinki convention, were randomly divided into 2 groups (treated group or TG and control group or CG). The 40 patients were chosen from compensated glaucoma sufferers, who required neither changes in therapy nor operations which would affect their eye pressure which was measured both before and after manipulative osteopathic treatment scheduled into 4 sessions at intervals of 7.3 and 150 days, then compared with the control group (20 patients) who were undergoing pharmacological treatment only. Results The average IOP in the TG was compared with the CG throughout the entire treatment cycle showing a statistically inconclusive reduction in the right eye RE P-value (0.0561), while for the left eye a significant effect was shown LE (0.0073). The difference between the reduction in IOP between TG and CG was observable 10 months after the first session or rather 5 months after the last, and demonstrable during a check-up 13 months after the beginning of the study, or rather 8 months in absence of treatment with a highly significant statistical p-value (0.000434). Conclusions This study has shown that manipulative osteopathic treatment can affect intraocular pressure after each session and that the pressure is significantly lower even months after the last treatment session.

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Section: Discussionmentioning

confidence: 99%

Section: Introduction and Aimsmentioning

confidence: 93%

The Glymphatic System and New Etiopathogenic Hypotheses Concerning Glaucoma Based on Pilot Study on Glaucoma Patients Who Underwent Osteopathic Manipulative Treatment (OMT)

Paoli¹,

Michelin²,

Vassallo³

et al. 2022

BIJCROO

View full text Add to dashboard Cite

show abstract

“…Support for the efficiency of osteopathic treatments in neurodegenerative pathologies, such as glaucoma, could be attributed to the positive influence that these treatments would have not only on the IOP but also on the cerebral vascular perfusion, also enabling to influencing venous, lymphatic, and CSF circulation by facilitating its drainage (20)(21)(22)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35).…”

Section: Discussionmentioning

confidence: 99%

“…This presupposes that hemodynamic changes can be, at least in part, a primary factor in patients with glaucoma (8,9). This further explains the effect of osteopathic manipulative treatment (OMT) in areas, such as cervical-cranial, aiming at an overall improvement in lymphatic drainage and vascular perfusion inside the cranium (20)(21)(22)(23)(24)(25)(26).…”

Section: Introduction and Aimsmentioning

confidence: 99%

A Glymphatic System and New Etiopathogenic Hypothesis on Glaucoma Patients Who Underwent Osteopathic Manipulative Treatment: A Pilot Study

Paoli,

Michelin,

Vassallo

2022

BIJCROO

View full text Add to dashboard Cite

Purpose Malfunction of the lymphatic or glymphatic system recently shown in the brain, seems to play an important role in central neurodegenerative pathologies through a build-up of neurotoxins. Recent studies have shown functional links between aqueous humour and cerebrospinal fluid via the glymphatic system, offering new perspectives and unifying theories on the vascular, biomechanical and biochemical causes of chronic and openangle glaucoma (POAG). The aim of this randomized pilot study is to compare the variations in intraocular pressure between 20 cases of compensated POAG under pharmacological therapy and 20 glaucoma patients undergoing osteopathic treatment, hypothesizing that this manipulation can influence intraocular pressure. Materials and Methods The 40 patients under study, all covered by the Helsinki convention, were randomly divided into 2 groups (treated group or TG and control group or CG). The 40 patients were chosen from compensated glaucoma sufferers, who required neither changes in therapy nor operations which would affect their eye pressure which was measured both before and after manipulative osteopathic treatment scheduled into 4 sessions at intervals of 7.3 and 150 days, then compared with the control group (20 patients) who were undergoing pharmacological treatment only. Results The average IOP in the TG was compared with the CG throughout the entire treatment cycle showing a statistically inconclusive reduction in the right eye RE P-value (0.0561), while for the left eye a significant effect was shown LE (0.0073). The difference between the reduction in IOP between TG and CG was observable 10 months after the first session or rather 5 months after the last, and demonstrable during a check-up 13 months after the beginning of the study, or rather 8 months in absence of treatment with a highly significant statistical p-value (0.000434). Conclusions This study has shown that manipulative osteopathic treatment can affect intraocular pressure after each session and that the pressure is significantly lower even months after the last treatment session.

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Periferik Arter Hastalığı Tanılı Hastalarda Tek Seans Osteopatik Manuel Tedavinin Femoral Arter Çapı ve Debisine Etkisi

ORAL,

ATALAY GÜZEL,

KESER

et al. 2023

Osmangazi̇ Journal of Medicine

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The aim of this study is to investigate the effect of a single osteopathic manuel treatment (OMT) session on femoral artery diameter and flow in patients diagnosed with (Peripheral Arterial Disease) PAD. 15 patients, diagnosed with PAD, (11 male, 4 female) were included in the study. The OMT circulation model was applied to the participants for one session. Before and after the application, femoral artery diameter and flow were evaluated by radiologist. Evaluating the diameter and flow parameters according to affected extremity, it was found that femoral artery diameter and flow values showed an increase in all patients; however, the difference was not found to be statistically significant. However, comparing diameter and flow parameters in all patients showed an increase in left and right femoral artery diameter and flow. Right femoral artery diameter parameter was found to have a statistically significant difference when compared to the parameter before the application of OMT (p=0,014). While a single session of OMT did not yield statistically significant results in artery diameter and flow in affected extremities, clinically increases were detected.

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Lymphatic Pump OMT Releases Cytokines Into Central Circulation

Cited by 4 publications

References 4 publications

The Glymphatic System and New Etiopathogenic Hypotheses Concerning Glaucoma Based on Pilot Study on Glaucoma Patients Who Underwent Osteopathic Manipulative Treatment (OMT)

The Glymphatic System and New Etiopathogenic Hypotheses Concerning Glaucoma Based on Pilot Study on Glaucoma Patients Who Underwent Osteopathic Manipulative Treatment (OMT)

A Glymphatic System and New Etiopathogenic Hypothesis on Glaucoma Patients Who Underwent Osteopathic Manipulative Treatment: A Pilot Study

Periferik Arter Hastalığı Tanılı Hastalarda Tek Seans Osteopatik Manuel Tedavinin Femoral Arter Çapı ve Debisine Etkisi

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