Lymphatic Mapping and Sentinel Node Analysis: Current Concepts and Applications

Chen, Steven L.; Iddings, D.; Scheri, Randall P.; Bilchik, Anton J.

doi:10.3322/canjclin.56.5.292

Cited by 135 publications

(112 citation statements)

References 158 publications

(167 reference statements)

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“…În nodulii limfatici cu diametrul mai mic de 5 mm s-au găsit metastaze, ce au reprezentat 17% [14]. Identificarea nodulului santinelă, bine documentată în melanom şi în cancerul de sân, are rezultate controversate în cancerul de colon datorită concordanţei scăzute între metastazele din nodulii limfatici şi nodulul santinelă [5,22]. Diferite metode folosite pentru identificarea nodulului santinelă sunt nesigure, deoarece au o sensibilitate redusă şi o rată înaltă a valorii predictive negative, ceea ce reduce acurateţea stadializării cancerului de colon.…”

Section: Discuţiiunclassified

“…Scăderea numărului de noduli limfatici fără metastaze examinaţi după rezecţia chirurgicală se asociază cu creşterea supravieţuirii. Creşterea supravieţuirii este corelată cu creşterea numărului (peste 12) nodulilor limfatici extirpaţi şi examinaţi şi cu creşterea numărului limfonodulilor negativi [3][4][5][6][20][21][22][23][24][25][26][27][28][29]. Rata supravieţuirii la 5 ani este de 80-90% în absenţa metastazelor în nodulii limfatici şi de 40% când acestea sunt prezente.…”

Section: Discuţiiunclassified

“…Clasificarea TNM în care se ia în considerare numărul nodulilor limfatici regionali cu metastaze, are valoare predictivă mai mare decât clasificarea Dukes [27]. Analizele multivariate arată că metastazele în nodulii limfatici regionali au valoare statistică semnificativă pentru supravieţuire [4,12,20,22,27,[31][32][33][34][35][36][37][38][39][40][41]. Detalii ale supravieţuirii în funcţie de numărul nodulilor limfatici cu metastaze, aduce…”

Section: Discuţiiunclassified

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Metastatic Lymphadenopathy in Colon Cancer

Păunescu¹,

Pop-Began²,

Pop-Began³

et al. 2013

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METASTATIC LYMPHADENOPATHY IN COLON CANCER (Abstract): INTRODUCTION:The incidence and prevalence of colon cancer is increasing in the last decades, in Romania. The aim of this paper is to evaluate the place of metastatic lymphadenopathy as risk factor for postoperative morbidity and mortality. MATHERIAL AND METHODS: We perfomed a prospective study; 126 patients with colon cancer were included and prospectively reviwed. RESULTS: The men / women ratio was 70 / 56. The mean age was 65.26 years old (range 20-89 years). Most cases were in stage III (n=72, 57.14%) and IV (n=49, 38.89%) with tumors located more frequently on the left colon (n=86, 68.25%) and especially on the sigmoid colon (n=64, 50.79%). 33.33% patients (n=42) were operated in emergency. Colic wall invasion depth (pT 3 =49, 38.9%, pT 4 =72, 57.1%) were accompanied by an increase in the number of affected regional lymph nodes (pN 1 =29, 23.0%, pN 2 =43, 34.1%). Postoperative complications occurred only in patients in stages III (n=11, 15.41%) and IV (n=15, 30.61%). The 30 days postoperative mortality rate was 19.04% (n=24), mostly in stage pT 4 tumors (n=18, 25%). Metastatic adenopathy was found as risk factor for postoperative mortality rate: 16.66% (n=4) deaths for pN 1 , 30.23% (n=13) for pN 2 and resoectively 13.07% (n=7) mortality rate for pN 0 . The five years survival rate was 100% for stage I, 59.64% for stage II, 33.57% for stage III and nul for stage IV. CONCLUSIONS: The presence of metastatic adenopathy is crucial in assessing the informational value of early and late postoperative evolution.

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Section: Discuţiiunclassified

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Metastatic Lymphadenopathy in Colon Cancer

Păunescu¹,

Pop-Began²,

Pop-Began³

et al. 2013

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“…SLNs can be more than one lymph node and also can exist in more than one direction ( Fig. 1) (Chen et al, 2006;Tangoku et al, 2007). SLN tracing techniques have been widely used in clinical practice for many solid tumors such as melanoma, breast cancer, and colorectal carcinoma, and excellent clinical results have been achieved (Shimazu and Noguchi, 2011;Erman et al, 2012;van der Zaag et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

二级前哨淋巴结示踪技术: 进展期胃癌根治术中淋巴结示踪新方法

Jiang

Song

et al. 2015

J. Zhejiang Univ. Sci. B

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Abstract:Objective: To explore the feasibility and clinical value of secondary sentinel lymph node (SSLN) tracing technique in radical gastrectomy for advanced gastric cancer (AGC). Methods: From January 2009 to June 2011, 247 patients who suffered from gastric angle cancer with metastasis in No. 3 group lymph nodes were divided randomly into groups A and B. Methylthioninium chloride was injected into the peripheral tissue of the metastatic No. 3 group lymph nodes of 138 patients in group A before tumor resections. SSLNs were traced and individual lymphadenectomies were carried out based on the biopsy results of the SSLNs. Standard D2 radical gastrectomies were carried out directly on 109 patients in group B. Postoperative follow-up and survival analysis were carried out for patients in both groups. Results: SSLNs were found in 114 (82.6%) patients in group A. Ninety of those patients (78.9%) demonstrated existing metastasis in SSLNs. According to Kaplan-Meier's method, the postoperative 3-year cumulative survival rates were 63.5% and 47.5%, and the median survival time were 40 and 36 months for the patients of groups A and B, respectively (P<0.05). Conclusions: The SSLN tracing technique is feasible in radical gastrectomy for AGC. It gives surgeons important information about the terminal status of lymph node metastasis and provides some scientific basis for individual lymphadenectomy.

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“…It becomes more accurate when an imaging modality is used for identifying the SLN near the tumor during the biopsy procedure. During SLNB, unnecessary dissection for metastasis is not very common under image guidance [6]. Choosing the right imaging method navigates the correct SLN accurately and that could reduce the loss of healthy breast tissue and falsenegative results.…”

Section: Introductionmentioning

confidence: 99%

Breast sentinel lymph node biopsy with imaging towards minimally invasive surgery

Joseph

Oepen

Friebe

2017

Biomedical Engineering / Biomedizinische Technik

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Breast sentinel lymph nodes are still commonly assessed through complete lymph node dissections, which is a time-consuming and radical approach because the nodes are difficult to identify. To prevent false diagnosis and achieve accurate results, minimally invasive, imageguided procedures are applied and constantly improved. The purpose of this paper is to present the currently used imaging modalities ultrasound, fluorescence, single-photon emission computed tomography (SPECT), magnetic resonance imaging (MRI) and hybrid imaging methods and comparing their effectiveness for breast sentinel lymph node biopsy. A definition for an ideal imaging system combining efficient minimally invasive techniques with workflow considerations is also discussed. As a conclusion, upcoming imaging methods and their future outlook with areas of advancement are presented.

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Lymphatic Mapping and Sentinel Node Analysis: Current Concepts and Applications

Cited by 135 publications

References 158 publications

Metastatic Lymphadenopathy in Colon Cancer

Metastatic Lymphadenopathy in Colon Cancer

二级前哨淋巴结示踪技术: 进展期胃癌根治术中淋巴结示踪新方法

Breast sentinel lymph node biopsy with imaging towards minimally invasive surgery

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