Lymphatic Mapping and Sentinel Lymphadenectomy for 106 Head and Neck Lesions: Contrasts Between Oral Cavity and Cutaneous Malignancy

Civantos, Francisco; Moffat, Frederick L.; Goodwin, W. Jarrard

doi:10.1097/01.mlg.0000200750.74249.79

Cited by 118 publications

(94 citation statements)

References 53 publications

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“…Our experience specific to the head and neck region was published in 2006 [17]. In our experience, 14 out of 103 cases (13.6%) had sentinel lymph nodes outside of expected lymph node basins.…”

Section: Sentinel Node Biopsy Of the Head And Neck Region: General Comentioning

confidence: 89%

Sentinel node biopsy for squamous cell carcinoma of the head and neck

Civantos

Zitsch

Bared

et al. 2008

Journal of Surgical Oncology

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The clinical utility of sentinel node biopsy for melanoma has led multiple investigators to apply this approach to other cutaneous malignancies as well as to early cancers of the upper aerodigestive tract. Data are most extensive for oral cancer. A multi-institutional pathologic validation trial for selected oral cancers provided negative predictive values of 96%. Subsequent trials should document clinical follow-up. This technique may ultimately play a wider role in the management of mucosal cancers.

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Section: Sentinel Node Biopsy Of the Head And Neck Region: General Comentioning

confidence: 89%

Sentinel node biopsy for squamous cell carcinoma of the head and neck

Civantos

Zitsch

Bared

et al. 2008

Journal of Surgical Oncology

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“…SN biopsy is considered a useful approach for the detection of subclinical nodal metastasis in patients diagnosed clinically as N0, and the efficacy of SN biopsy was reported and established for patients with oral cancer [6][7][8].…”

Section: Discussionmentioning

confidence: 99%

“…Recently, the concept of sentinel lymph node (SN) was established for head and neck squamous cell carcinomas, particular for oral cancer [6][7][8]. This study aimed to investigate intra-arterially injected cisplatin distribution to the regional nodes by comparing platinum concentrations in SNs and non-sentinel lymph nodes (NSNs).…”

Section: Introductionmentioning

confidence: 99%

Platinum concentration in sentinel lymph nodes after preoperative intra-arterial cisplatin chemotherapy targeting primary tongue cancer

Sakashita¹,

Homma²,

Suzuki³

et al. 2012

Acta Oto-Laryngologica

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Conclusion.We concluded that intra-arterially injected cisplatin passed via lymph flow into sentinel nodes (SNs) as the platinum concentration in the SNs was higher than that in the non-sentinel nodes (NSNs). It is possible that pre-operative intra-arterial chemotherapy targeting primary cancer also has a therapeutic effect on subclinical metastatic SNs.Objectives. Intra-arterial chemoradiotherapy has been reported to be effective against not only primary tumors but also nodal metastases. We considered the hypothesis that intra-arterially injected cisplatin passed via lymph flow into regional nodes. This study aimed to investigate intra-arterially injected cisplatin distribution to regional nodes by comparing platinum concentrations in SNs and NSNs.Method. Five patients with T1-2 N0 tongue cancer were treated with preoperative intra-arterial chemotherapy (cisplatin, 100mg/m 2 ) targeting primary cancer. Partial glossectomy together with SN biopsy and elective neck dissection were performed two weeks after intra-arterial chemotherapy. Platinum concentrations in the lymph nodes were measured using a Zeeman atomic absorption spectrometer.Results. Thirteen SNs were harvested together with 8 NSNs from the adjacent areas to the SNs. Platinum concentrations were then measured, revealing a significant difference in platinum concentration between the SNs and the NSNs (mean±SD, 0.682±0.246 µg/g vs 0.506±0.274 µg/g; p=0.049).

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“…SLNB procedures used in oral cavity and oropharynx lesions have a reported SLN detection rate of 97% (12)(13)(14)(15)(16). Because there were no false-negative results in our study, we had a negative predictive value of 100%.…”

Section: Discussionmentioning

confidence: 95%

The Value of Sentinel Lymph Node Biopsy in Oral Cavity Cancers

Kaya

Göde

Öztürk

et al. 2015

Turk Arch Otorhinolaryngol

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Objective: The aim of this study was to establish the effectiveness of sentinel lymph node biopsy in the detection of metastasis in N0 necks of T1-T2 early-stage oral cavity cancers. Materials and Methods:Twenty neck dissections were performed in 18 patients diagnosed with T1 and T2 oral cavity cancer, with an indication for elective neck dissection between November 2007 and January 2011. The male to female ratio was 12:8, with a mean age of 54.5 years (range 28-76). Eight of the dissections were performed for lower lip cancer, 7 for tongue cancer, and 5 for floor of the mouth cancer. Sentinel lymph node biopsy was used to detect metastatic lymph nodes. Tc99m radionuclide injection was administered to the periphery of the tumor 24 h before the operation, and a lymphoscintigraphy image was obtained 30 min after the injection. Sentinel lymph nodes were localized and excised on the day of surgery using static lymphoscintigraphy images and a gamma probe. Sentinel lymph nodes were sent for a frozen section examination, and either a selective or a comprehensive neck dissection was performed for each neck according to the results. Results:After the final histopathological examination of the specimens, the negative predictive value, the positive predictive value, the accuracy of the sentinel lymph node biopsy, and frozen section accuracy were found to be 100%. Conclusion:Sentinel lymph node biopsy was found to be an efficient method in the pathological staging and management of the N0 neck in early T-stage oral cavity cancers.Keywords: Oral cavity, carcinoma, sentinel lymph node biopsy, lymphatic metastasis, neck dissection, squamous cell carcinoma Abstract 62

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Lymphatic Mapping and Sentinel Lymphadenectomy for 106 Head and Neck Lesions: Contrasts Between Oral Cavity and Cutaneous Malignancy

Cited by 118 publications

References 53 publications

Sentinel node biopsy for squamous cell carcinoma of the head and neck

Sentinel node biopsy for squamous cell carcinoma of the head and neck

Platinum concentration in sentinel lymph nodes after preoperative intra-arterial cisplatin chemotherapy targeting primary tongue cancer

The Value of Sentinel Lymph Node Biopsy in Oral Cavity Cancers

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