Lymphatic Mapping and Gamma Probe Guided Laparoscopic Biopsy of Sentinel Lymph Node in Patients With Clinical Stage I Testicular Tumor

Οhyama, Chikara; Chiba, Yutaka; Yamazaki, Tetsuro; Endoh, Mareyuki; Hoshi, Senji; Arai, Yoichi

doi:10.1016/s0022-5347(05)64456-4

Cited by 36 publications

(21 citation statements)

References 17 publications

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“…The technique of lymphatic mapping with SLNB can potentially be used to identify lymph notes harboring micrometastasis. Preliminary data show that lymphoscintigraphy for SLN identification is feasible in Stage I testicular cancer using intratesticular radiocolloid administration in combination with laparoscopic SLNB 89.…”

Section: Sln Micrometastasis and Clinical Outcome In Genitourinary Camentioning

confidence: 99%

“…Several authors investigated the feasibility and accuracy of radio‐guided mapping of SLNs for men with clinical Stage I testicular tumor. After undergoing radical orchiectomy, patients underwent laparoscopic SLNB follwed by retroperitoneal lymph node dissection 88, 89. Nearly all SLNs were detected at the ventral or lateral side of the vena cava or at the aorta between the levels of L1, L2 to the aortic bifurcation.…”

Section: Sln Micrometastasis and Clinical Outcome In Genitourinary Camentioning

confidence: 99%

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Impact of nodal status and tumor burden in sentinel lymph nodes on the clinical outcomes of cancer patients

Leong

Zuber

Ferris

et al. 2011

Journal of Surgical Oncology

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The validation of sentinel lymph node (SLN) concept in melanoma and breast cancer has established a new paradigm in cancer metastasis that, in general, cancer cells spread in a orderly fashion from the primary site to the SLNs in the regional nodal basin and then to the distant sites. In this review article, we examine the development of SLN concept in penile carcinoma, melanoma and breast carcinoma and its application to other solid cancers with emphasis of the relationship between micrometastasis in SLNs and clinical outcomes.

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Section: Sln Micrometastasis and Clinical Outcome In Genitourinary Camentioning

confidence: 99%

Section: Sln Micrometastasis and Clinical Outcome In Genitourinary Camentioning

confidence: 99%

Impact of nodal status and tumor burden in sentinel lymph nodes on the clinical outcomes of cancer patients

Leong

Zuber

Ferris

et al. 2011

Journal of Surgical Oncology

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“…The feasibility of the SN procedure in TGCTs has already been established in several smaller series [12][13][14][15], including a prospective study from our institution [15]. In the present paper, we report the long-term results of this approach, with additional data from a patient registry.…”

Section: Introductionmentioning

confidence: 86%

Sentinel node biopsy in clinical stage I testicular cancer enables early detection of occult metastatic disease

et al. 2019

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ObjectivesTo report the long‐term results of the sentinel node (SN) approach in patients with clinical stage I testicular tumours in our facility.Patients and MethodsWe conducted an analysis of 27 consecutive patients suspected of clinical stage I testicular germ cell tumour (TGCT) and treated with an SN procedure at our tertiary referral centre. SNs were identified using lymphoscintigraphy with or without single‐photo‐emission computed tomography with CT (SPECT/CT). Patients underwent laparoscopic retroperitoneal SN excision with inguinal orchiectomy. Patients with a tumour‐positive SN underwent adjuvant treatment. Follow‐up was conducted according to then‐current guidelines.ResultsIn two patients, no SNs were visualized on scintigraphy. In the remaining 25 patients, a median (range) of 3 (1–4) SNs per patient were removed. Two patients showed no malignancy on histopathological examination of the testis. Of the 23 patients diagnosed with TGCT (16 seminomas, seven non‐seminomas), three (13.0%) had occult metastatic disease. All 23 patients were without evidence of disease at a median (range) follow‐up of 63.9 (29.0–143.4) months.ConclusionThe SN procedure allows early identification of patients with occult metastatic disease in clinical stage I TGCT, enabling early treatment.

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“…Two groups have assessed the feasibility of the technique in testicular cancer. The larger of the two series, from Japan [16], analysed the detection of the SLN in 10 clinically stage‐1 patients, then used a gamma probe laparoscopically to biopsy the SLN in five further patients; the last patient in the series also had a unilateral retroperitoneal LND to confirm the status of the SLN.…”

Section: Testicular Cancermentioning

confidence: 99%

“…They could detect the SLN in all patients, and all except one of the SLNs were free from metastatic disease. In the only patient with a positive node, a retroperitoneal LND confirmed that the SLN contained the only focus of metastatic disease [16]. The second group [17] reported on five patients, and used a combination of patent blue dye and 99m Tc‐nanocolloid to locate the SLN.…”

Section: Testicular Cancermentioning

confidence: 99%

Current status of dynamic lymphoscintigraphy and sentinel lymph‐node biopsy in urological malignancies

Hadway¹,

Lynch²,

Heenan³

et al. 2005

BJU International

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2 3 5The lymphatics were mapped using lymphangiograms taken via the dorsal penile lymphatics. The SLN was located initially using an anterior-posterior radiograph. The junction of the femoral head and the ascending ramus of the pubis were found most often to contain the SLN centre. This corresponded anatomically to the lymph nodes adjacent to the superficial epigastric vein, which were located medial and superior to the epigastric-saphenous junction.The technique involved a 5-cm incision parallel to the inguinal ligament, centred 4.5 cm lateral and 4.5 cm distal to the pubic tubercle. A finger was then inserted under the upper flap in the direction of the pubic tubercle. The SLN was located within 1 cm of the superficial epigastric vein in all cases. Often two or three nodes were excised, and the SLN was always taken to be the largest, most medial node. In this series, 46 patients had SLN biopsy, of which 15 contained metastases on histological evaluation. Inguinal lymph node dissections (LNDs) were then conducted, and 12 of the 15 were found to have no further disease other than that in the SLN. Metastases were not found in other lymph nodes when the SLN was negative.The 5-year survival rates were reported to be 90% if the SLN was negative, 70% if the SLN was the only positive node, and 50% if the SLN was positive with other nodal involvement. No false-negative results were reported. Six patients who were SLN-negative had a LND because of palpable nodes within 3 years; all were negative for metastases after resection. Cabanas concluded that a LND was only required when the SLN was positive. Close clinical surveillance was recommended in the negative group.

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Lymphatic Mapping and Gamma Probe Guided Laparoscopic Biopsy of Sentinel Lymph Node in Patients With Clinical Stage I Testicular Tumor

Cited by 36 publications

References 17 publications

Impact of nodal status and tumor burden in sentinel lymph nodes on the clinical outcomes of cancer patients

Impact of nodal status and tumor burden in sentinel lymph nodes on the clinical outcomes of cancer patients

Sentinel node biopsy in clinical stage I testicular cancer enables early detection of occult metastatic disease

Current status of dynamic lymphoscintigraphy and sentinel lymph‐node biopsy in urological malignancies

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