Lymphatic invasion in Spitz nevi

Howat, A. J.; Variend, S.

doi:10.1097/00000478-198502000-00007

Cited by 42 publications

(15 citation statements)

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“…Nevertheless, some benign conditions showing lymphatic or blood vessel invasion have been reported previously and these include cutaneous nevi [15], sclerosing adenosis of the breast [16], and vasitis nodosa [17]. It might be supposed that looking for vascular invasion with elastic stains may not only increase the detection rate of vascular invasion but may highlight its presence in previously unsuspected conditions as suggested by Eusebi and Azzopardi [16].…”

Section: Discussionmentioning

confidence: 96%

Vascular invasion demonstrated by elastic stain—a common phenomenon in benign granular cell tumors

Sejben

2008

Virchows Arch

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Granular cell tumor is generally benign, but rare malignant cases have been documented. Features of malignancy include necrosis, cellular spindling, vesicular nuclei with large nucleoli, increased mitotic activity, high nuclear to cytoplasmic ratio, and pleomorphism, but not vascular invasion. Venous invasion was incidentally identified with the orcein elastic stain in an otherwise benign granular cell tumor (propositus case). Four further benign granular cell tumors were also analyzed; venous invasion was discovered in three. It is suggested that vascular invasion is not uncommon in granular cell tumors and should not lead to the classification of the tumor as malignant or atypical. It is likely that in most cases there is only invasion of the vascular wall. It is also suggested that some cases of vascular invasion identified by elastic stains in tumors such as colorectal carcinomas (where these stains are recommended for routine use) may also represent invasion of vascular structures without the propensity of metastasis.

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Section: Discussionmentioning

confidence: 96%

Vascular invasion demonstrated by elastic stain—a common phenomenon in benign granular cell tumors

Sejben

2008

Virchows Arch

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“…In Spitz's nevi, it is not rare to find melanocytes in the lymphatics (12), but lymphatic vessel invasion by melanocytes as far as 13 mm from the tumor edge has not been reported. Still, the inguinal lymph nodes were not palpable, and a follow-up study revealed no lymph nodal enlargement.…”

Section: Discussionmentioning

confidence: 98%

“Malignant Spitz Nevus” in a 2‐Year‐Old Japanese Child

Nitta

Ohkochi

Hara

1995

The Journal of Dermatology

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Smith et al. (1989) have reported a variant of Spitz's nevus with histological atypical features. Despite local lymph node metastases, further metastases were not observed. They proposed the name "malignant Spitz nevus" for this variant. A 2-year-old Japanese girl had a large nodule (27 x 17 mm) surrounded by an indurated erythema over the Achilles tendon. Histologically, it proved to be a melanocytic lesion resembling spindle cell and epithelioid cell nevus (Spitz's nevus) with unusual features; the tumor extended deep into the subcutis, and the mitotic figures deep into the tumor, together with prominent lymphatic vessel invasion by melanocytes. Thus the tumor was aptly termed "malignant Spitz nevus". Flow cytometric analysis of the DNA content revealed a diploid pattern. The child is well 5 years after a wide resection of the tumor. The diploid pattern of the DNA content as well as the good prognosis could support the idea that "malignant Spitz nevus" fits within the spectrum of Spitz's nevus.

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“…Moreover, some benign conditions can show lymphatic or blood vessel invasion, as in congenital melanocytic naevus,15 Spitz naevus,16 sclerosing adenosis of the breast,17 vasitis nodosa18 or neurofibromatosis 19. In these lesions, vascular invasion is restricted to the subendothelial layers of the vessel, as in granular cell tumours.…”

Section: Discussionmentioning

confidence: 99%