Lymphatic invasion identified with D2-40 immunostaining as a risk factor of nodal metastasis in T1 colorectal cancer

Abstract

Lymphatic vessel invasion diagnosed with D2-40 was a better indicator to evaluate the risk for lymph node metastasis by T1 colorectal cancer.

‘Head Invasion' Is Not a Metastasis-Free Condition in Pedunculated T1 Colorectal Carcinomas Based on the Precise Histopathological Assessment

“…There are very few reports describing the association between patient sex and LNM [37] ; therefore, our results cannot be explained and further research is needed. As another important point, in non-pedunculated lesions, it is well-known that lymphovascular infiltration is an important risk factor for LNM [6,8,11,40] ; however, our results showed that lymphovascular infiltration was not a sig- 173 nificant factor for LNM in pedunculated lesions. We also found that the stalk invasion group had a tendency to harbor less lymphatic infiltration than the head invasion group (18/28, 39.1% vs. 16/14, 53.3%, respectively).…”

“…In contrast, approximately 10% of T1CC cases are associated with LNM; therefore, the resected specimen must be examined to determine whether there is a clini-cally significant risk of LNM that would warrant additional surgery [4][5][6][7][8][9][10][11] . Previously, histopathological factors such as the degree of submucosal invasion, lymphovascular infiltration, poor differentiation, and tumor budding were reported to be associated with LNM [6,[12][13][14][15][16][17][18] . However, in pedunculated tumor types, interpreting the degree of submucosal invasion is relatively complicated compared with other morphological types because of the presence of a stalk.…”

Systematic review and meta-analysis of histopathological predictive factors for lymph node metastasis in T1 colorectal cancer

“…Only five publications ultimately met the inclusion criteria and these were chosen for further analysis in our systematic review ( Fig. 1) [17][18][19][20][21].…”

Expression of D2-40 in Benign and Malignant Breast Lesions and Study the Correlation between Lymphovascular Density and other Prognostic Factors of Breast Cancer

“…Many studies have evaluated D2-40 expression in various malignant neoplasms. Positivity of D2-40 was helpful in detecting lymphatic tumor emboli and was associated with poorer prognosis in early colorectal cancer, esophageal squamous cell carcinoma, and small cell lung cancer [9][10][11]. D2-40 is one of the most specific and sensitive markers to determine tumor cells in lymphatic vessels.…”