Lymphatic function is required prenatally for lung inflation at birth

Jakus, Zoltán; Gleghorn, Jason P.; Enis, David R.; Sen, Aslihan; Chia, Stephanie; Liu, Xi; Rawnsley, David R.; Yang, Yi‐Qing; Hess, Paul R.; Zou, Zhiying; Yang, Jun; Guttentag, Susan H.; Nelson, Celeste M.; Kahn, Mark L.

doi:10.1084/jem.20132308

Cited by 69 publications

(86 citation statements)

References 38 publications

(63 reference statements)

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“…Other work in which VEGF-C was selectively overexpressed in the airways during embryonic day 15.5 to postnatal day 14 caused lymphatics near airways to take on an enlarged, sac-like morphology that was dysfunctional and produced respiratory distress and pulmonary lymphangiectasia (1172). Collectively, these findings implicate an important role for pulmonary lymphatics in respiratory distress syndrome in premature infants (472). …”

Section: Organization and Anatomy Of The Lymphatic Systemmentioning

confidence: 79%

“…Recent work utilizing Ccbe1- or Vegfr3-deficient mice, which lack lymphatic vessels, die at birth because they are unable to inflate their lungs after birth (472). While previously it was estimated that lymphatics remove about only about 11% of the fluid from fetal lungs at birth of lambs, at the same time it was also determined that lymph flow from the lung does not increase significantly due to birth (101).…”

Section: Organization and Anatomy Of The Lymphatic Systemmentioning

confidence: 99%

“…This work suggested that lymphatic clearance of fluid occurs prenatally. In fact, data from the study utilizing Ccbe1- and Vegfr3-deficient mice revealed that pulmonary lymphatic function is present prior to birth, and that it is a prerequisite for increased lung compliance that occurs in late gestation (472). Other work in which VEGF-C was selectively overexpressed in the airways during embryonic day 15.5 to postnatal day 14 caused lymphatics near airways to take on an enlarged, sac-like morphology that was dysfunctional and produced respiratory distress and pulmonary lymphangiectasia (1172).…”

Section: Organization and Anatomy Of The Lymphatic Systemmentioning

confidence: 99%

See 2 more Smart Citations

Lymphatic Vessel Network Structure and Physiology

Breslin

Yang

Scallan

et al. 2018

Comprehensive Physiology

264

258

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The lymphatic system is comprised of a network of vessels interrelated with lymphoid tissue, which has the holistic function to maintain the local physiologic environment for every cell in all tissues of the body. The lymphatic system maintains extracellular fluid homeostasis favorable for optimal tissue function, removing substances that arise due to metabolism or cell death, and optimizing immunity against bacteria, viruses, parasites, and other antigens. This article provides a comprehensive review of important findings over the past century along with recent advances in the understanding of the anatomy and physiology of lymphatic vessels, including tissue/organ specificity, development, mechanisms of lymph formation and transport, lymphangiogenesis, and the roles of lymphatics in disease.

show abstract

Section: Organization and Anatomy Of The Lymphatic Systemmentioning

confidence: 79%

Section: Organization and Anatomy Of The Lymphatic Systemmentioning

confidence: 99%

Section: Organization and Anatomy Of The Lymphatic Systemmentioning

confidence: 99%

See 1 more Smart Citation

Lymphatic Vessel Network Structure and Physiology

Breslin

Yang

Scallan

et al. 2018

Comprehensive Physiology

264

258

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“…20 Mice with severe lymphatic defects often exhibit massive embryonic edema and lethality 21 ; and if they survive until the neonatal period, they have severe problems caused by pulmonary edema. 22 The systemic absence of the lymphatic vasculature thus seems to be incompatible with life. In adults, the cardinal manifestation of lymphatic dysfunction is lymphedema.…”

Section: Tissue Fluid Homeostasismentioning

confidence: 99%

Lymphatic System in Cardiovascular Medicine

Aspelund

Robciuc

Karaman³

et al. 2016

Circulation Research

266

258

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Abstract:The mammalian circulatory system comprises both the cardiovascular system and the lymphatic system. In contrast to the blood vascular circulation, the lymphatic system forms a unidirectional transit pathway from the extracellular space to the venous system. It actively regulates tissue fluid homeostasis, absorption of gastrointestinal lipids, and trafficking of antigen-presenting cells and lymphocytes to lymphoid organs and on to the systemic circulation. The cardinal manifestation of lymphatic malfunction is lymphedema. Recent research has implicated the lymphatic system in the pathogenesis of cardiovascular diseases including obesity and metabolic disease, dyslipidemia, inflammation, atherosclerosis, hypertension, and myocardial infarction. Here, we review the most recent advances in the field of lymphatic vascular biology, with a focus on cardiovascular disease.

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“…The availability of protocols for the isolation/purification of ECs from different vascular beds (32) or the lymphatics (54,109) may enable their targeted use in bioengineering different segments of the pulmonary vascular, the bronchial circulation, or the lymphatic tree. A review of the lymphatic endothelium, however, as important as it is for lung function during development (39) and in the mature organ, is beyond the scope of this review.…”

Section: Pulmonary Vascular Organizationmentioning

confidence: 99%