Lymphatic drainage of hypertonic solution from peritoneal cavity of anesthetized and conscious sheep

Tran, Lisa; Rodela, Helen; Abernethy, Nevin J.; Yuan, Zhixiang; Hay, J. B.; Oreopoulos, D. G.; Johnston, Mary

doi:10.1152/jappl.1993.74.2.859

Cited by 27 publications

(12 citation statements)

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“…It has previously been reported that respiratory movement is reduced in anesthetized animals lying on their back (38,39). Other investigators have also previously found decreased lymphatic outflow from the peritoneum under anesthesia (40)(41)(42) and have speculated that abdominal muscle tone plays a large role in driving flow out of the peritoneum. This concept is in agreement with our findings, although more research is necessary to elucidate the major driving forces for lymphatic flow from this serous cavity.…”

Section: Discussionmentioning

confidence: 89%

Quantitative measurement of lymphatic function in mice by noninvasive near-infrared imaging of a peripheral vein

Proulx¹,

Ma²,

Andina³

et al. 2017

JCI Insight

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Section: Discussionmentioning

confidence: 89%

Quantitative measurement of lymphatic function in mice by noninvasive near-infrared imaging of a peripheral vein

Proulx¹,

Ma²,

Andina³

et al. 2017

JCI Insight

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“…In large an imals like sheep, lymph How rates have been measured by cannulation [5,11]. Unfortu nately, each small lymphatic vessel that drains the peritoneal cavity cannot be cannulated, so instead, investigators cannulate larger vessels further downstream from the peritoneal cavity.…”

Section: Direct Methodsmentioning

confidence: 99%

“…macromolecular tracers (by monitoring the mass of i.p. tracer that en ters a given lymph compartment and dividing by the concentration of the tracer in the peri toneal cavity) [11], One drawback with this technique is that the cannulation process may affect the flow rate [ 12], Moreover, since can nulation is not ethically feasible in humans, use of this technique to estimate lymph flow during PD requires extrapolation from ani mal data.…”

Section: Direct Methodsmentioning

confidence: 99%

Pathways for Fluid Loss from the Peritoneal Cavity

Shockley

Ofsthun²

1992

Blood Purif

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During peritoneal dialysis, fluid is transported out of the peritoneal cavity by lymphatic and nonlymphatic pathways, thereby decreasing net ultrafiltration by 40-50% and reducing small solute clearance by 15-20%. The direct lymphatic pathway consists of the diaphragmatic lymphatics, which directly connect the peritoneal cavity to the bloodstream. The interstitial lymphatic and direct blood entry pathways convey fluid that has been driven into the interstitial space of the tissue surrounding the peritoneal cavity by the increased intraperitoneal pressure, and return it to the bloodstream. Since flow through lymphatic pathways is only a portion of the flow through all pathways, total fluid loss is greater than lymph flow. The best technique for estimating lymph flow is direct measurement by cannulation of lymphatic vessels, a technique that is not clinically feasible. The tracer disappearance technique, which measures the rate at which macromolecules leave the peritoneal cavity, is an indirect measure of fluid loss. The tracer appearance technique, which measures the rate at which macromolecules reach the blood from the peritoneal cavity, slightly overestimates lymph flow because some tracer may enter the bloodstream directly from the tissues. Much of the previous controversy over the contribution of the lymphatic pathways to total fluid loss can be resolved by understanding the differences in what these techniques measure.

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“…Recent studies have demonstrated that the thoracic duct plays a specific role in lymphatic drainage from the serosal cavity of quadrupeds (43)(44)(45). Therefore, anatomical differences in the thoracic duct and the duct tributaries may also affect the outcomes of lymphogenous metastases.…”

Section: Serosal Membranes Lymphatic Stomata and Coelomic Fluid Draimentioning

confidence: 99%

The role of the lymphatic system in rabbit models for cancer metastasis research: a perspective from comparative anatomy

Oshiro

2014

Okajimas Folia Anat. Jpn.

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Summary:The elucidation of the pathogenesis of human diseases requires increasingly relevant and rigorous animal models. Therefore, investigators must select an appropriate mammalian model. Mice and rats are indispensable in the understanding of the mechanisms of human diseases, but other non-rodent mammals are required in certain situations. The rabbit is one such species. The rabbit exhibits greater biological similarities to humans than the mouse or rat, and the rabbit VX2 allograft cancer model has been used in a broad range of oncological studies, such as stromal responses, metastatic behaviors and therapeutic effects. Cancer cells in this model proliferate in a host rabbit that maintains a natural immunity, which makes this model attractive and unique. However, these examples constitute only a small number of advantages of a rabbit model. Numerous reports suggest that the rabbit is an attractive cancer-bearing animal model for the study of cancer metastasis and the lymphatic system. I briefly review the relevant medical literature and compare the rabbit lymphatic system with mice, rats and humans.

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Lymphatic drainage of hypertonic solution from peritoneal cavity of anesthetized and conscious sheep

Cited by 27 publications

References 0 publications

Quantitative measurement of lymphatic function in mice by noninvasive near-infrared imaging of a peripheral vein

Quantitative measurement of lymphatic function in mice by noninvasive near-infrared imaging of a peripheral vein

Pathways for Fluid Loss from the Peritoneal Cavity

The role of the lymphatic system in rabbit models for cancer metastasis research: a perspective from comparative anatomy

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