Lymphatic and Tissue Filariasis

Hübner, Marc P.; Layland, Laura E.; Hoerauf, Achim

doi:10.1007/978-3-031-00303-5_14

Cited by 1 publication

(1 citation statement)

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“…The location of these parasites within the human body varies from species to species. Filariasis affects a range of human tissues and often evinces little or no observable host response throughout their development [ 22 , 23 ]. An exception occurs when the parasite enters extremely sensitive tissues, such as the conjunctiva [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

Beyond Tradition: Exploring Cutting-Edge Approaches for Accurate Diagnosis of Human Filariasis

Pietrzak,

Łuczak,

Wiśniewski

2024

Pathogens

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Filariasis is recognised as a global public health threat, particularly in tropical and subtropical regions. It is caused by infection with a nematode parasite of the superfamily Filarioidea, including Wuchereria bancrofti, Brugia malayi, Onchocerca volvulus, and Onchocerca lupi. Three main types of filariasis have been classified: lymphatic filariasis, subcutaneous filariasis, and serous cavity filariasis. The symptoms exhibited by individuals afflicted with filariasis are diverse and contingent upon several variables, including the species of parasite, the host’s health and immune response, and the stage of infection. While many classical parasitological techniques are considered indispensable tools for the diagnosis of parasitic infections in humans, alternative methods are being sought due to their limitations. Novel tests based on host–parasite interactions offer a rapid, simple, sensitive, and specific diagnostic tool in comparison to traditional parasitological methods. This article presents methods developed in the 21st century for the diagnosis of filariasis caused by invasion from W. bancrofti, B. malayi, O. volvulus, and O. lupi, as well as techniques that are currently in use. The development of modern diagnostic methods based on molecular biology constitutes a significant advancement in the fight against filariasis.

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Section: Introductionmentioning

confidence: 99%