Lymphangiosarcoma in postmastectomy lymphedema. A report of six cases in elephantiasis chirurgica

Stewart, Fred W.; Treves, Norman

doi:10.1002/1097-0142(194805)1:1<64::aid-cncr2820010105>3.0.co;2-w

Cited by 767 publications

(161 citation statements)

References 1 publication

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“…Two patients with a malignant peripheral nerve sheath tumour had associated neurofibromatosis. Six patients had disease associated with the treatment of breast cancer, three with classical Stewart-Treves syndrome (lymphoedemaassociated angiosarcoma) 19 and three with radiationinduced sarcoma.…”

Section: Resultsmentioning

confidence: 99%

Major amputation for soft-tissue sarcoma

Clark

Thomas

2002

British Journal of Surgery

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Background: Advances in oncological practice have reduced the number of major amputations performed for soft-tissue sarcoma, but this remains a valuable, if infrequent, option for both curative and palliative indications.Methods: A review of patients and case-notes was carried out from the prospective sarcoma database at the Royal Marsden Hospital.Results: Over a 10-year interval, 40 major amputations (18 forequarter, 17 hindquarter and five through hip) were performed, predominantly for disease recurring after previous limb-conserving surgery (31 of 40). A wide variety of soft-tissue sarcoma subtypes was seen; they were often large (more than 10 cm; 18 of 40) or multifocal (six), usually high grade (25), and frequently proximal or involving neurovascular structures such that limb salvage was precluded. Median range age of the patients was 59 (17-87) years. The operative 30-day mortality rate was zero. Hospital stay was a median of 10·5 days for forequarter amputation, and 19 days for hindquarter and through-hip amputation. Local recurrence occurred in ten patients, six of whom had concurrent distant metastases. Twenty-seven patients were alive (20 disease free) at a median follow-up of 12 months, nine of whom were alive without evidence of disease beyond 2 years. Ten patients died after a median of 7·5 months; three survived more than 2 years. Conclusion:Major amputation is a useful procedure in carefully selected patients with soft-tissue sarcoma.

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Section: Resultsmentioning

confidence: 99%

Major amputation for soft-tissue sarcoma

Clark

Thomas

2002

British Journal of Surgery

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“…19 Angiosarcomas are also observed after lymphedema from any cause, be it surgical, filarial or congenital, and defined as Stewart-Treves syndrome. 20 …”

Section: Pathogenesismentioning

confidence: 99%

Malignant vascular tumors—an update

2014

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“…The latency period of ST syndrome appears to be 10 to 12 years, slightly longer than that for RAS. 6,29,30 Several patients in our series also had angiosarcoma that may have been associated with chronic lymphedema and, thus, was hard to distinguish from ST syndrome.…”

Section: Discussionmentioning

confidence: 83%

Reirradiation and hyperthermia for radiation‐associated sarcoma

Jong

Oldenborg

Oei

et al. 2011

Cancer

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BACKGROUND:The objective of this study was to evaluate the role of reirradiation and hyperthermia in the treatment of radiation-associated sarcoma (RAS) in the thoracic region, which is an increasing, yet extremely rare condition with a poor prognosis. METHODS: Between 1979 and 2009, 16 patients with RAS in the thoracic region were treated in the Academic Medical Center and the Institute Verbeeten with reirradiation and hyperthermia. In 13 patients, this treatment was given for unresectable disease and 3 times after resection as adjuvant treatment. The median latency period between the original malignancy diagnosis and the RAS diagnosis was 86 months (range 19-212 months). Histology was angiosarcoma in 11 patients (69%). The literature on reirradiation with or without hyperthermia for RAS was reviewed. RESULTS: The median survival was 15.5 months (range, 3-204 months). Four patients were not evaluable for response. The response rate for the remaining 12 patients was 75% (7 complete responses and 2 partial responses). Six patients remained free of local failure until death (5 months and 7 months) or last follow-up (8 months, 11 months, 39 months, and 68 months). CONCLUSIONS: The current study indicates that combined reirradiation and hyperthermia for RAS in the thoracic region is feasible. The high response rate and the possibility of durable local control suggest that this treatment is promising. Cancer 2012;118:180-

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Lymphangiosarcoma in postmastectomy lymphedema. A report of six cases in elephantiasis chirurgica

Cited by 767 publications

References 1 publication

Major amputation for soft-tissue sarcoma

Major amputation for soft-tissue sarcoma

Malignant vascular tumors—an update

Reirradiation and hyperthermia for radiation‐associated sarcoma

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