Lymphangiosarcoma associated with hyonatraernia and hyperkalaemia in a dog

Lamb, W. A.; Muir, Peter

doi:10.1111/j.1748-5827.1994.tb01722.x

Cited by 16 publications

(21 citation statements)

References 4 publications

(3 reference statements)

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“…It was first documented in a dog in 1981 . To date, 18 dogs have been reported in the literature with LAS ranging in age from 8 weeks to 13 years . Lymphangiosarcoma commonly presents in dogs as a subcutaneous mass or focal swelling.…”

Section: Introductionmentioning

confidence: 99%

“…Lymphangiosarcoma commonly presents in dogs as a subcutaneous mass or focal swelling. Lesions have been reported in the cervical region and thoracic inlet, inguinal region, hind limb, axillary region and forelimb, thoracic cavity and mediastinum, thoracic subcutis, and retroperitoneal space with vaginal prolapse . Most reported cases occurred in large breed dogs including a Giant Schnauzer, Standard Poodle, Bouvier des Flandres, Golden Retriever, Doberman Pinscher, pointer, Chow Chow, Bullmastiff, Siberian husky, Boxer, and Chesapeake Bay retriever, and one occurred in a Toy Poodle .…”

Section: Introductionmentioning

confidence: 99%

“…Most reported cases occurred in large breed dogs including a Giant Schnauzer, Standard Poodle, Bouvier des Flandres, Golden Retriever, Doberman Pinscher, pointer, Chow Chow, Bullmastiff, Siberian husky, Boxer, and Chesapeake Bay retriever, and one occurred in a Toy Poodle . Most cases had a short clinical course once a diagnosis was made, and commonly had evidence of metastasis at the time of diagnosis …”

Section: Introductionmentioning

confidence: 99%

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Lymphangiosarcoma in 12 dogs: a case series (1998–2013)

Curran

Halsey

Worley

2014

Vet Comparative Oncology

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Lymphangiosarcoma (LAS) is an uncommon malignant neoplasia arising from lymphatic endothelium; little information exists regarding therapy. Single institutional retrospective review for canine LAS histopathology diagnoses over a 15-year period yielded 12 dogs. Ten dogs were presented for a mass and/or swelling at cervical, trunk or limb regions. Prior to diagnosis, 10 dogs received empiric wound therapy. Cytology performed in 10 consisted of mild inflammation. Survival ranged from 60, 168 and 876 days for three dogs with palliation; 90 days with prednisone in one; 182 days with chemotherapy in one; 240, 267, 487, 630 and 941 days for five receiving surgery; and 574 days for one receiving surgery, radiation and chemotherapy. One dog is alive with recurrence at 243 days following surgery and carboplatin chemotherapy. Clinical improvement existed in LAS dogs receiving multimodal therapies. Early tissue biopsies are recommended for progressive oedematous lesions of unknown origin.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Lymphangiosarcoma in 12 dogs: a case series (1998–2013)

Curran

Halsey

Worley

2014

Vet Comparative Oncology

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“…Lymphangiosarcoma is an extremely rare, generally aggressive malignant tumour which has been reported in humans 3,5,19,26 , only 16 dogs 1,4,8,9,[14][15][16][17][18]20,22,24,27,29 , a similar number of cats 19,11,12,25,28 , 2 horses 13,23 , and a cow 21 . Lymphangiosarcoma in dogs, with comparison with that in humans, is reviewed in a companion article 30 .…”

Section: Introductionmentioning

confidence: 99%

Lymphangiosarcoma in a 3.5-year-old Bullmastiff bitch with vaginal prolapse, primary lymph node fibrosis and other congenital defects : clinical communication

Williams¹,

Birrell²,

Wilpe³

2005

J. S. Afr. Vet. Assoc.

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Lymphangiosarcoma is an extremely rare tumour in dogs with only 16 cases reported in the literature. Lymphoedema, whichmaybe primary due to defects in the lymphatic system, or secondary to various other pathologies, often precedes malignancy. Of the 16 canine reports, only 1 dog was confirmed as having had prior primary lymphoedema due to aplasia of the popliteal lymph nodes. A case of lymphangiosarcoma is described in a 3.5-year-old purebred, Bullmastiff bitch which presented with vaginal blood 'spotting' for 3 weeks after cessation of oestrus, during which intromission by the male had been unsuccessful. During ovariohysterectomy a large multicystic, proliferative, spongy, fluid-filled, brownish-red mass surrounding the cervix and projecting into the abdominal space was removed with the cervix, and a diagnosis of lymphangiosarcoma made on histological and electron microscopic examination of the tissue. Ultrastructurally, no basement membrane or pericytes were found, only some of the neoplastic endothelial cells were linked by tight junctions while there were gaps between others, and neither micropinocytotic vesicles nor Weibel-Palade bodies occurred in the cells examined.Very few of the endothelial cells lining the many interlinking, tortuous maze of channels, stained slightly positive immunohistochemically for factor VIII-related antigen. The channels were filled mostly with serous fluid, and occasionally mixed leucocytes and some erythrocytes. The endothelium was often associated with underlying blocks of collagenous material, as well as looselyarranged aggregates of lymphocytes, other mononuclear cells and occasional neutrophils in the connective tissue septae and more prominently perivascularly. The bitch was discharged on antibiotic treatment but returned 2 weeks later with apparent prolapsed vagina which failed to reduce over the next week. Laparotomy revealed the tumour to have spread extensively in the caudal abdomen to involve the broad ligament and the ventral rectal serosa, and the 'prolapsed' tissue was found to be expanded vaginal wall. The bitch was euthanased and necropsied, Histological examination confirmed lymphangiosarcomatous invasion of the submucosal and muscular layers of the retroperitoneal, traumatised, prolapsed part of the vagina, the urethra and the ventral rectal wall. The broad ligament was diffusely invaded with tumour which had proliferated into the caudal abdominal space, and 3 small intra-trabecular foci of tumour were found in the right popliteal lymph node near the hilus. Mitotic figures were generally scarce. There was mild subcutaneous oedema of the ventral trunk extending from the axillae to the inner proximal thighs, which had not been evident clinically, and the lymph nodes (peripheral more so than internal) microscopically showed marked trabecular and perivascular fibrosis especially in hilar regions. Other congenital defects were hepatic capsular and central venous fibrosis with lymphatic duplication and dilatation in all areas of connective tissue, ventrally-incongruou...

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“…Mediastinal and visceral lymphatic trunk lymphangiosarcomas have been described in horses, 2 dogs 3 and cats 4 and a pulmonary localization has been documented in a dog 5 . The subcutaneous compartment is another frequent site of occurrence of the tumour 6–13 . The skin and subcutis of the caudal abdomen appear to be the commonest site for lymphangiosarcomas in the cat and this tumour has thus been called ‘abdominal angiosarcoma’ in this species 14–18 .…”

Section: Introductionmentioning

confidence: 99%

Feline lymphangiosarcoma – definitive identification using a lymphatic vascular marker

Galeotti

Barzagli

Vercelli

et al. 2004

Veterinary Dermatology

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Three cases of feline exudative dermatitis associated with lymphangiosarcoma are described. The animals, an 11-year-old, neutered male and two 10-year-old, neutered female short hair European cats, presented with a 2-month history of transparent liquid oozing from the skin of the groin and caudal abdomen. On physical examination the neutered male cat and one of the females were slightly depressed and showed loss of weight. Skin lesions were similar in all cats and characterized by the presence of alopecia and moist dermatitis in the ventral abdomen, groin and inner thigh. The hair at the periphery appeared matted by the fluid. In all three cases, histopathological examination of skin biopsies from the abdomen identified poorly defined neoplasia involving dermis and subcutis, characterized by proliferation of spindle cells aligned along pre-existing collagen bundles. The dissection of collagen bundles gave rise to irregular shaped anastomosing, often blind-ending vascular channels and trabeculae. Vascular spaces were mostly optically empty. These histological features were strongly suggestive of lymphangiosarcoma. Neoplastic cells were positive for the blood vascular marker Von Willebrand factor, and a lymphatic vascular marker LYVE-1 (Lymphatic Vessel Endothelial receptor - 1), demonstrating the mixed vascular origin of the tumour. Ultrastructural findings confirmed the final diagnosis of lymphangiosarcoma.

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Lymphangiosarcoma associated with hyonatraernia and hyperkalaemia in a dog

Cited by 16 publications

References 4 publications

Lymphangiosarcoma in 12 dogs: a case series (1998–2013)

Lymphangiosarcoma in 12 dogs: a case series (1998–2013)

Lymphangiosarcoma in a 3.5-year-old Bullmastiff bitch with vaginal prolapse, primary lymph node fibrosis and other congenital defects : clinical communication

Feline lymphangiosarcoma – definitive identification using a lymphatic vascular marker

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