“…The development of angiosarcoma in a chronically lymphedematous extremity was first described by Stewart and Treves in 1948 after their observation of this syndrome in women with breast cancer treated with radical mastectomy. 5,6 There are several hundred cases reported in the literature, the majority of which are described in the upper extremity after aggressive locoregional therapy for locally advanced breast cancer. Stewart-Treves syndrome (STS) has also been observed in the lower extremity and can result from congenital, idiopathic, traumatic, filarial, or postsurgical causes of lymphedema.…”