Lymphangiogenesis and colorectal cancer

Huang, Ciyou; Chen, Yigang

doi:10.15537/smj.2017.3.16245

Cited by 20 publications

(12 citation statements)

References 54 publications

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“…When lymphatic vessels are distributed in the submucosa, lymph node metastasis is likely to occur when the tumor invades the submucosa. When the tumor invades the deep intestinal wall, the lymph node metastasis rate will increase significantly[ 28 , 29 ]. In our study, the lymph node metastasis rate of this group of patients with T1-stage CRC was 8.41%, which is mostly consistent with previous reports[ 7 , 8 ].…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of lymph node metastasis in patients with T1-stage colorectal cancer from multiple centers in China

Sun

Zhou

et al. 2017

WJG

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AIMTo explore the features and prognostic value of lymph node metastasis in patients with T1-stage colorectal cancer (CRC).METHODSIn all, 321 cases of T1-stage CRC were selected from 10132 patients with CRC who received surgical therapy in six large-scale hospitals in China and were retrospectively analyzed. Univariate and multivariate analyses were performed to analyze the risk factors for lymphatic metastasis. A survival analysis was then performed to analyze the prognostic value of lymph node metastasis.RESULTSThe occurrence rate of T1 stage was 3.17% (321/10132); of these patients, the lymph node metastasis rate was 8.41% (27/321), and the non-lymph node metastasis rate was 91.59% (294/321). Univariate analysis showed that preoperative serum CEA, preoperative serum CA199, preoperative serum CA724, vascular invasion, and degree of differentiation were associated with lymph node metastasis in T1-stage CRC (P < 0.05 for all). Multivariate analysis indicated that preoperative serum CA724, vascular invasion, and degree of differentiation were closely related to lymph node metastasis (P < 0.05 for all). Log-rank survival analysis showed that age, preoperative serum CEA, preoperative serum CA199, vascular invasion, degree of differentiation, and lymph node metastasis (χ2 = 24.180, P < 0.001) were predictors of 5-year overall survival (OS) (P < 0.05 for all). COX regression analysis demonstrated that preoperative serum CA199 and lymph node metastasis (HR = 5.117; P < 0.05; 95%CI: 0.058-0.815) were independent prognostic indicators of 5-year OS in patients with T1-stage CRC (P < 0.05 for both).CONCLUSIONThe morbidity of T1-stage CRC was 3.17% for all CRC cases. Preoperative serum CA724, vascular invasion, and degree of differentiation are independent risk factors for lymph node metastasis. Lymph node metastasis is an independent prognostic factor for OS in patients with T1-stage CRC.

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Section: Discussionmentioning

confidence: 99%

Prognostic value of lymph node metastasis in patients with T1-stage colorectal cancer from multiple centers in China

Sun

Zhou

et al. 2017

WJG

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“…During metastasis, they provide a pathway for tumor cell dissemination. 145,146 Lymphangiogenesis (the process where new lymphatic vessels are formed) occurs in and around tumors 147 . In colorectal tumors, there is a correlation between lymphatic microvessel density and risk of metastasis 146 .…”

Section: Lymphangiogenesismentioning

confidence: 99%

Therapeutic Targeting of the Colorectal Tumor Stroma

et al. 2020

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Colorectal tumors have been classified based on histologic factors, genetic factors, and consensus molecular subtypes, which all affect the tumor microenvironment (TME). Elements of the TME serve as therapeutic targets and might be used as prognostic factors. For example, immune checkpoint inhibitors are used to treat tumors with microsatellite instability, and anti-angiogenic agents may be used in combination with other drugs to slow or inhibit tumor growth. We review the features of the colorectal tumor stroma that associate with outcomes of patients and discuss potential therapeutic agents that target these features.

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“… 18 To date, the overexpression of VEGF-C has been found to be noticeably related to LN metastasis in primary tumors and poor prognosis in cancer patients including breast, lung, and colorectal cancers. 19 20 21 22 Similarly, our previous studies have shown that high expression of VEGF-C was related to elevated lymphatic vessel density (LVD), lymphatic vessel invasion (LVI), and LN metastasis in human PCa. 23 …”

Section: Introductionmentioning

confidence: 83%

Coexpression of TLR9 and VEGF-C is associated with lymphatic metastasis in prostate cancer

Zeng¹,

Huang²,

Fang

et al. 2022

Asian J Androl

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Prostate cancer (PCa) is one of the most frequent cancers in men, and its biomolecular targets have been extensively studied. This study aimed to analyze the expression of toll-like receptor 9 (TLR9) and vascular endothelial growth factor C (VEGF-C) and the clinical value of the coexpression of TLR9 and VEGF-C in PCa. We retrospectively evaluated 55 patients with clinically localized, intermediate-risk, or high-risk PCa who underwent laparoscopic radical prostatectomy (LRP) and extended pelvic lymph node dissection (ePLND) without neoadjuvant hormonal therapy at a single institution from June 2013 to December 2016. In all 55 patients, the median number of lymph nodes (LNs) resected was 23 (range: 18–31), and a total of 1269 LNs were removed, of which 78 LNs were positive. Seventeen patients had positive LNs, with a positive rate of 30.9%. In addition, the immunohistochemical results in the above patients revealed that high TLR9 expression was correlated with higher Gleason score (GS) ( P = 0.049), increased LN metastasis ( P = 0.004), and more perineural invasion (PNI) ( P = 0.033). Moreover, VEGF-C expression was associated with GS ( P = 0.040), pathological stage (pT stage) ( P = 0.022), LN metastasis ( P = 0.003), and PNI ( P = 0.001). Furthermore, a significant positive correlation between TLR9 and VEGF-C was found ( P < 0.001), and the TLR9/VEGF-C phenotype was associated with LN metastasis ( P = 0.047). Collectively, we propose that TLR9 stimulation may promote LN metastasis in PCa cells through the upregulation of VEGF-C expression, thereby affecting the prognosis of PCa patients. Therefore, these markers may serve as valuable targets for the treatment of PCa.

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Lymphangiogenesis and colorectal cancer

Cited by 20 publications

References 54 publications

Prognostic value of lymph node metastasis in patients with T1-stage colorectal cancer from multiple centers in China

Prognostic value of lymph node metastasis in patients with T1-stage colorectal cancer from multiple centers in China

Therapeutic Targeting of the Colorectal Tumor Stroma

Coexpression of TLR9 and VEGF-C is associated with lymphatic metastasis in prostate cancer

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