Lymphadenopathy Associated Virus in Aids, Lymphadenopathy Associated Syndrome, and Classic Kaposi Patients in Greece

Papaevangelou, G; Economidou, J.; Kallinikos, J; Choreimi, H; Mandalaki, T.; Stratigos, J.; Geroldi, Diego; Barré‐Sinoussi, Françoise; Chermann, J.-C.; Montagnier, Luc

doi:10.1016/s0140-6736(84)90635-4

Cited by 8 publications

(7 citation statements)

References 4 publications

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“…Also the following features have been widely reported: onset more frequent in the fifth to eighth decade and more or less marked male predominance (range of M/F ratio from 2 to 15:1) [8, 171; a significantly high incidence in individuals of Ashkenazi Jewish and Mediterranean ori gin [4][5][6][7][8][9]; range of average survival periods 6 -1 3 years [12,13,18,19]; special risk of developing diabetes mellitus [6,15,20]; significantly higher frequency of association with second primary malignancies, especially of the lymphoreticular system [11,21]. To our knowledge, the series presented herein is the largest collected so far.…”

Section: Discussionmentioning

confidence: 99%

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Classical Kaposi’s Sarcoma: A Survey of 163 Cases Observed in Bari, South Italy

Lospalluti¹,

Mastrolonardo

Loconsole

et al. 1995

Dermatology

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Background: Classical Kaposi’s sarcoma (KS) is a sporadic disease that is particularly prevalent in Mediterranean countries. Objective: The aim of the study was to update clinical information about this rare condition. Methods: A survey of 163 cases observed in the period 1971-1990 in Bari, South Italy, was carried out. All records were reviewed and, when lost to follow-up for more than 6 months, patients were called back to update personal and family histories. The age at onset averaged 64 years (range 18-85). The male-to-female ratio was 3:1. No familiar occurrence was identified, and no significant association was found with other conditions (i.e. second primary malignancies and diabetes mellitus). Death from KS occurred in 16 cases, at the mean age of 71 years, an average of 5.7 years after the onset of the disease. To assess whether the different clinical patterns of the disease in its earlier stages may give any indication of its subsequent clinical course, all cases were re-classified into three groups (low-, moderate- and high-eruptivity group) on the basis of both the extent and the rate of spread of the disease before first admission; group-stratified survival function was evaluated using Kaplan-Meier’s life table method. Results: Highly significant (p < 0.0001) differences were found in survival profiles of the three study groups, also when only deaths due to KS were computed. Conclusion: These findings provide some support to the hypothesis that three subsets of classical KS exist that have different prognoses and, consequently, need different therapeutic approaches.

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Section: Discussionmentioning

confidence: 99%

“…However, it remains unclear whether racial or environmental factors are responsible for the relatively high prevalence rates reported in Mediterranean countries [4][5][6][7][8][9]. Bari, the chief town of Apulia, Southern Italy, is located in this low endemic area.…”

mentioning

confidence: 99%

Classical Kaposi’s Sarcoma: A Survey of 163 Cases Observed in Bari, South Italy

Lospalluti¹,

Mastrolonardo

Loconsole

et al. 1995

Dermatology

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“…Since the identification of human immunodeficiency virus type 1 (HIV-1) as the cause of AIDS, one of the greatest challenges has been the development of a vaccine that will prevent infection and/or ameliorate disease progression (38,43). Although over 100 phase I, II, and III vaccine clinical trials of different candidates have been conducted all over the world, only a few candidates have advanced to efficacy testing and none has yet to show any benefit in prevention or control of HIV-1 (HIV Vaccine Database; www.iavi.org).…”

mentioning

confidence: 99%

Human Immunodeficiency Virus Type 1 Elite Neutralizers: Individuals with Broad and Potent Neutralizing Activity Identified by Using a High-Throughput Neutralization Assay together with an Analytical Selection Algorithm

Simek

Rida

Priddy

et al. 2009

J Virol

533

560

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The development of a rapid and efficient system to identify human immunodeficiency virus type 1 (HIV-1)-infected individuals with broad and potent HIV-1-specific neutralizing antibody responses is an important step toward the discovery of critical neutralization targets for rational AIDS vaccine design. In this study, samples from HIV-1-infected volunteers from diverse epidemiological regions were screened for neutralization responses using pseudovirus panels composed of clades A, B, C, and D and circulating recombinant forms (CRFs). Initially, 463 serum and plasma samples from Australia, Rwanda, Uganda, the United Kingdom, and Zambia were screened to explore neutralization patterns and selection ranking algorithms. Samples were identified that neutralized representative isolates from at least four clade/CRF groups with titers above prespecified thresholds and ranked based on a weighted average of their log-transformed neutralization titers. Linear regression methods selected a five-pseudovirus subset, representing clades A, B, and C and one CRF01_AE, that could identify top-ranking samples with 50% inhibitory concentration (IC 50 ) neutralization titers of >100 to multiple isolates within at least four clade groups. This reduced panel was then used to screen 1,234 new samples from the Ivory Coast, Kenya, South Africa, Thailand, and the United States, and 1% were identified as elite neutralizers. Elite activity is defined as the ability to neutralize, on average, more than one pseudovirus at an IC 50 titer of 300 within a clade group and across at least four clade groups. These elite neutralizers provide promising starting material for the isolation of broadly neutralizing monoclonal antibodies to assist in HIV-1 vaccine design.

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“…The hypothesis that AIDS is an epidemic form of the endemic variety of African KS (Weber, 1984) is not supported in this study. The same holds true for the classical European form, in which a recent study in Greece failed to demonstrate LAV antibodies (Papaevangelou et al, 1984). Notwithstanding the high incidence of KS in the Katana area, no cases of childhood lymphadenopathy have been diagnosed in the area , giving credit to Templeton's (1972) suggestion that the distribution of endemic generalized cases might differ from that of the more usual skin forms.…”

Section: Discussionmentioning

confidence: 77%

Endemic african kaposi's sarcoma is not associated with immunodeficiency

Kestens

Melbye

Biggar

et al. 1985

Intl Journal of Cancer

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Twenty-seven histologically confirmed Kaposi sarcoma (KS) patients resident in the Kivu Lake area of eastern Zaire were examined for immune competence. Only KS cases of the endemic African type have been observed in this high-incidence area. The median duration of the symptoms was 6 years and ranged from 1 to 38 years. Forty-one controls matched for age, sex and tribe and unrelated to the KS patients were selected from the community. Thirteen additional controls were first-degree relatives of the KS patients. No evidence of immune suppression among KS patients was found and there were no significant differences in the immune status between KS patients and controls. Total lymphocytes, B and T cells, and OKT4+ and OKT8+ cells varied within the normal range. Grouping of the KS patients in categories according to duration and disease extent did not reveal significant differences in their immune status. The number of KS patients reacting positively in a skin test to 5 recall antigens and I mitogen was similar to that of controls, except in the case of candidin, to which a higher number of KS patients were negative. The serum levels of immunoglobulins, complement factors and circulating immune complexes were comparable in KS patients and controls. Indicators of inflammatory processes [white blood cells (WBC), complement-reactive protein (CRP)] were positive in 27% of the KS patients. The prevalence and mean titer of antibody against cytomegalovirus (CMV), Epstein-Barr virus (EBV), hepatitis B virus (HBV) and syphilis were similar in KS patients and in controls.

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Lymphadenopathy Associated Virus in Aids, Lymphadenopathy Associated Syndrome, and Classic Kaposi Patients in Greece

Cited by 8 publications

References 4 publications

Classical Kaposi’s Sarcoma: A Survey of 163 Cases Observed in Bari, South Italy

Classical Kaposi’s Sarcoma: A Survey of 163 Cases Observed in Bari, South Italy

Human Immunodeficiency Virus Type 1 Elite Neutralizers: Individuals with Broad and Potent Neutralizing Activity Identified by Using a High-Throughput Neutralization Assay together with an Analytical Selection Algorithm

Endemic african kaposi's sarcoma is not associated with immunodeficiency

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