Lymphadenopathy as a manifestation of amyloidosis: a case series

Fu, Julie; Seldin, David C.; Berk, John L.; Sun, Fangui; O’Hara, Carl; Cui, Haili; Sanchorawala, Vaishali

doi:10.3109/13506129.2014.958610

Cited by 26 publications

(27 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Localized lymph node amyloidosis is usually managed conservatively in asymptomatic patients; however, in symptomatic patients, surgical debulking, laser, or radiation therapy can be used. 43 Pleural amyloidosis with eff usions is managed by repeated thoracentesis, chest tube placement, and pleurodesis.…”

Section: Radiologic Discussionmentioning

confidence: 99%

A 70-Year-Old Man With Large Cervical and Mediastinal Lymphadenopathies

Narechania

Valent

Farver

et al. 2015

Chest

View full text Add to dashboard Cite

We present a case of a 70-year-old man with enlarged mediastinal and cervical lymph nodes that provided interesting radiologic and pathologic observations. The 70-year-old black man was found to have enlarged mediastinal lymph nodes. He had symptoms of atypical chest pain and generalized weakness for 2 weeks prior to the diagnosis. He denied shortness of breath, fever, chills, or night sweats. He was treated for hypertension and onychomycosis.Basic laboratory fi ndings were within normal limits. Pulmonary function tests at the time of presentation showed FEV 1 , FVC, and FEV 1 /FVC ratio of 123% predicted, 133% predicted, and 0.7, respectively. Meanwhile, total lung capacity and carbon monoxide diff using capacity were 103% and 107% predicted, respectively. Two weeks before he presented to our institution, the patient underwent bronchoscopy with transbronchial biopsies of the right lower lobe and endobronchial ultrasound-guided transbronchial needle aspiration of the right hilar lymph nodes.CHEST 2015; 148 ( 1 ) Th e patient's clinical examination was unremarkable except for a palpable right cervical lymph node of 3 cm in diameter with rubbery consistency. His lung examination was within normal limits.Chest radiography showed a soft tissue prominence in the right suprahilar and subcarinal regions. CT scan of the chest revealed multiple enlarged homogeneous lymph nodes with fi ne stippled calcifi cations in the paratracheal, subcarinal, and right hilar regions, the largest being 3.5 cm in diameter ( Fig 1 ). Tracheal dimensions and the appearance of the wall were normal ( Fig 1F ).Interferon-g release assay was positive; meanwhile, HIV enzyme-linked immunosorbent assay, histoplasma antigen, coccidioides antibody, syphilis IgG, and cryptococcal antigen were negative. Our initial diff erential diagnosis included sarcoidosis; TB or nontuberculous mycobacterial infection; lung, head, neck, or germinal cell cancer; lymphoma; histoplasmosis; and coccidioidomycosis.Tissue slides from both bronchoscopy and endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA), performed at an outside institution, were reviewed carefully. A biopsy specimen consisted of fi ve fragments of alveolated lung parenchyma, which were unremarkable, and three fragments of bronchial wall, which showed patchy, mild, nonspecifi c chronic infl ammation. A lymph node specimen did not show malignant cells. Gram and acid-fast bacillus stains and bacterial and mycobacterial cultures of the BAL specimen were negative.

show abstract

Section: Radiologic Discussionmentioning

confidence: 99%

A 70-Year-Old Man With Large Cervical and Mediastinal Lymphadenopathies

Narechania

Valent

Farver

et al. 2015

Chest

View full text Add to dashboard Cite

show abstract

“…There is currently no uniform standard treatment for primary laryngo-tracheobronchial amyloidosis, and therapies are limited, including surgery, laser surgery, endobronchial silicone stent implantation, radiation, chemotherapy, and oral dexamethasone [15]. Bronchoscopic recanalization therapy options include laser resection, bronchoscopic dilatation and stenting, and cryosurgery.…”

Section: Resultsmentioning

confidence: 99%

Primary Laryngo-Tracheobronchial Amyloidosis: A Case Report and Literature Review

Jiao¹,

Liu²,

Liu³

et al. 2017

J Clin Case Rep

View full text Add to dashboard Cite

Primary laryngo-tracheobronchial amyloidosis is a rare pulmonary disease for which there is currently no established treatment. Herein, we report a case involving a 51-year-old woman who was admitted to hospital primarily due to intermittent hoarseness. Botryoidal masses were visible at the entrance of the throat. On chest computed tomography, eccentric soft tissue density shadows were apparent in the tracheal bifurcation of the proximal segment of the trachea, and the lumen was narrowed. Electronic bronchoscopy revealed extensive new biological invasive growth from the nasopharynx to the glottis. The glottis and larynx were irregularly shaped with clear characteristics and congestion. New biological growth was also observed in the right upper lobe, right middle bronchus, and right lower lobe mucosa. The patient was ultimately diagnosed with primary laryngo-tracheobronchial amyloidosis via pathological analysis. Although amyloidosis is a benign lesion, to date, there are no curative treatments. The present article briefly highlights the pertinent literature, and discusses the clinical manifestations and progress of treatment in primary laryngo-tracheobronchial amyloidosis.

show abstract

“…Deposition in the LN can lead to lymphadenopathy, however, lymphadenopathy is uncommon in the setting of amyloidosis, being present in only 20% of cases . Lymphadenopathy as a presenting feature of amyloidosis is very rare (2% of cases) . The affected lymph nodes are usually in the lung hilum, mediastinum, axilla, neck, retroperitoneum and inguinal region (Fig.…”

Section: Amyloidosismentioning

confidence: 99%

“…33,34 Lymphadenopathy as a presenting feature of amyloidosis is very rare (2% of cases). 35 The affected lymph nodes are usually in the lung hilum, mediastinum, axilla, neck, retroperitoneum and inguinal region ( Fig. 5).…”

Section: Amyloidosismentioning

confidence: 99%

Review of axillary lesions, emphasising some distinctive imaging and pathology findings

2017

View full text Add to dashboard Cite

SummaryThe axilla is often included on mammography, ultrasound (US), CT and MRI. Axillary masses can arise from any of the tissue components present in this region including breast parenchyma. Aetiologies include: lymphadenopathy due to inflammation, malignancy and degenerative causes; soft tissue tumours such as haemangioma, lymphangioma, peripheral nerve sheath tumours and lipomas; post-surgical complications such as seroma, lymphocoele and haematoma; lesions arising in accessory breast tissue such as fibroadenoma and carcinoma. Some of these entities have distinctive imaging appearances knowledge of which can be helpful in suggesting the correct diagnosis.

show abstract

Lymphadenopathy as a manifestation of amyloidosis: a case series

Cited by 26 publications

References 20 publications

A 70-Year-Old Man With Large Cervical and Mediastinal Lymphadenopathies

A 70-Year-Old Man With Large Cervical and Mediastinal Lymphadenopathies

Primary Laryngo-Tracheobronchial Amyloidosis: A Case Report and Literature Review

Review of axillary lesions, emphasising some distinctive imaging and pathology findings

Contact Info

Product

Resources

About