Lymphadenitis due to &lt;i&gt;Mycobacterium terrae&lt;/i&gt; in an Immunocompetent Patient

Shimizu, Tadamichi; Furumoto, Hideyuki; Takahashi, Toru; Yasuno, Hirokazu; Muto, Mayumi

doi:10.1159/000018076

Cited by 5 publications

(4 citation statements)

References 19 publications

(12 reference statements)

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“…Mycobacterium terrae is an environmental, slow-growing mycobacterium, usually considered to be nonpathogenic to humans (Goodfellow and Magee 1998;Shimizu et al 1999). However, some cases of mycobacterial infections in lungs caused by this microbe have been diagnosed among both immunocompromised patients and patients with normal immunologic status (Krisher et al 1988;Kuze et al 1983;Palmero et al 1989;Peters and Morice 1991;Spence and Ferris 1996).…”

mentioning

confidence: 99%

“…However, some cases of mycobacterial infections in lungs caused by this microbe have been diagnosed among both immunocompromised patients and patients with normal immunologic status (Krisher et al 1988;Kuze et al 1983;Palmero et al 1989;Peters and Morice 1991;Spence and Ferris 1996). For example, M. terrae has provoked lymphadenitis in a nonimmunocompromised host (Shimizu et al 1999). We have previously shown that M. terrae, isolated from indoor air of a moisture-damaged building, is exceptionally potent in increasing the production of the inflammatory mediators tumor necrosis factor α (TNFα), interleukin-6 (IL-6), and nitric oxide in mouse macrophages in vitro (Huttunen et al 2000).…”

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confidence: 99%

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Mycobacterium terrae isolated from indoor air of a moisture-damaged building induces sustained biphasic inflammatory response in mouse lungs.

Jussila¹,

Komulainen²,

Huttunen³

et al. 2002

Environ Health Perspect

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Occupants in moisture-damaged buildings suffer frequently from respiratory symptoms. This may be partly due to the presence of abnormal microbial growth or the altered microbial flora in the damaged buildings. However, the specific effects of the microbes on respiratory health and the way they provoke clinical manifestations are poorly understood. In the present study, we exposed mice via intratracheal instillation to a single dose of Mycobacterium terrae isolated from the indoor air of a moisture-damaged building (1 X 10(7), 5 X 10(7), or 1 X 10(8) microbes). Inflammation and toxicity in lungs were evaluated 2 hr later. The time course of the effects was assessed with the dose of 1 X 10(8) bacterial cells for up to 28 days. M. terrae caused a sustained biphasic inflammation in mouse lungs. The characteristic features for the first phase, which lasted from 6 hr to 3 days, were elevated proinflammatory cytokine [i.e., tumor necrosis factor alpha (TNF-alpha) and interleukin-6 (IL-6)] levels in the bronchoalveolar lavage fluid (BALF). TNF-alpha was produced in the lungs more intensively than was IL-6. Neutrophils were the most abundant cells in the airways during the first phase, although their numbers in BALF remained elevated up to 21 days. The characteristics of the second phase, which lasted from 7 to 28 days, were elevated TNF-alpha levels in BALF, expression of inducible nitric oxide synthase in BAL cells, and recruitment of mononuclear cells such as lymphocytes and macrophages into the airways. Moreover, total protein, albumin, and lactate dehydrogenase concentrations were elevated in both phases in BALF. The bacteria were detected in lungs up to 28 days. In summary, these observations indicate that M. terrae is capable of provoking a sustained, biphasic inflammation in mouse lungs and can cause a moderate degree of cytotoxicity. Thus, M. terrae can be considered a species with potential to adversely affect the health of the occupants of moisture-damaged buildings.

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confidence: 99%

mentioning

confidence: 99%

Mycobacterium terrae isolated from indoor air of a moisture-damaged building induces sustained biphasic inflammatory response in mouse lungs.

Jussila¹,

Komulainen²,

Huttunen³

et al. 2002

Environ Health Perspect

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“…Therefore, cultures positive for these agents should be carefully interpreted. To date, few cases of human disease caused by M. terrae complex have been reported [3,4,[5][6][7][8][9][10][11][12][13][14][15][16], and isolation of M. terrae complex from HIV-infected patients has been described only in 1 series of 35 patients (isolation occurred only in 1 case, apparently without clinical disease) [1]. Our patient, therefore, represents the first HIV-related case of clinically relevant disseminated infection by M. terrae.…”

Section: Disseminated Mycobacterium Terrae Infection In a Patient Witmentioning

confidence: 91%

“…Up to 18% of isolates of nontuberculous mycobacteria [1,2] that are recovered from humans are M. terrae complex organisms, and these isolates are rarely related to clinical manifestations, thus signifying nonpathogenic colonization. A few cases of human disease that involved joints [3,4], lungs [5][6][7][8][9][10], skin [11], gut [12], urinary tract [13], and lymph nodes [14], or appeared as disseminated disease have been described elsewhere [15,16] lation occurred only in 1 case) [1], but clinical manifestations were not mentioned. We describe here an HIV-infected patient with disseminated infection by M. terrae that was associated with progressive pulmonary and cutaneous disease.…”

Section: Disseminated Mycobacterium Terrae Infection In a Patient Witmentioning

confidence: 99%

Disseminated Mycobacterium terrae Infection in a Patient with Advanced Human Immunodeficiency Virus Disease

Carbonara

Tortoli

Costa

et al. 2000

Clinical Infectious Diseases

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Mycobacterium terrae has been rarely implicated in human disease and never in patients infected with human immunodeficiency virus (HIV). We describe an HIV-infected patient with disseminated infection by M. terrae with pulmonary and cutaneous clinical manifestations. M. terrae was isolated from both sputum and urine, and identified by both conventional tests and high-performance liquid chromatography. Clinical and microbiological characteristics of this case are compared with those reported in the literature.

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NTM Disease Caused by M. kansasii, M. xenopi, M. malmoense, and Other Slowly Growing NTM

Marras

Brode

2018

Nontuberculous Mycobacterial Disease

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Lymphadenitis due to <i>Mycobacterium terrae</i> in an Immunocompetent Patient

Cited by 5 publications

References 19 publications

Mycobacterium terrae isolated from indoor air of a moisture-damaged building induces sustained biphasic inflammatory response in mouse lungs.

Mycobacterium terrae isolated from indoor air of a moisture-damaged building induces sustained biphasic inflammatory response in mouse lungs.

Disseminated Mycobacterium terrae Infection in a Patient with Advanced Human Immunodeficiency Virus Disease

NTM Disease Caused by M. kansasii, M. xenopi, M. malmoense, and Other Slowly Growing NTM

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