Lymphadenectomy for lung carcinoids: Which factors may predict nodal upstaging? A multi centric, retrospective study

Chiappetta, Marco; Lococo, Filippo; Sperduti, Isabella; Cusumano, Giacomo; Terminella, Alberto; Fournel, Ludovic; Guerrera, Francesco; Filosso, Pier Luigi; Tabacco, Diomira; Nicosia, Samanta; Alifano, Marco; Gallina, Filippo Tommaso; Facciolo, Francesco; Margaritora, Stefano

doi:10.1002/jso.26912

Cited by 2 publications

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“…A recent study, presented at the 34th EACTS annual meeting [ 23 ], reported a discrete rate of mediastinal and nodal upstaging in LC, especially in atypical and central tumours, with a remarkably increased rate in case of radical mediastinal dissection. Moreover, on average one positive node was harvested, which suggests that the extent of lymphadenectomy is a fundamental part of LC staging and post-operative management.…”

Section: Discussionmentioning

confidence: 99%

External Validation of a Prognostic Score for Survival in Lung Carcinoids

Chiappetta

Tabacco

Sassorossi

et al. 2022

Cancers

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Background: A prognostic score including T-dimension, age, histology and lymph node ratio was previously proposed in absence of an external validation dataset. The aim of the current study was to validate the proposed prognostic score using an independent dataset. Methods: Data of patients with lung carcinoids, who underwent surgical resection and lymphadenectomy in five institutions from 1 January 2005 to 31 December 2019, were retrospectively analyzed. Two risk groups were created based on the following data: age, histology, node ratio and pT for disease-free survival (DFS); age, sex, node ratio and pT for overall survival (OS). The previously proposed score was validated, identifying two groups of patients: a high risk (HRG) and low risk (LRG) group. Results: The final analysis was conducted on 283 patients. Regarding DFS, 230 (81.3%) patients were assigned to the LRG and 53 (18.7%) to the HRG. Considering OS, 268 (94.7%) were allocated in the LRG and 15 (5.3%) in the HRG. The 5-year DFS was 92.7% in the LRG vs. 67% in the HRG (p < 0.001) while the 5-year OS was 93.6% in the LRG vs. 86.2% in the HRG (p = 0.29) with clear curve separation. Conclusion: Our analysis confirmed the validity of the composite score for DFS in lung carcinoids. Regarding OS, statistical significance was not reached because of a low number of deaths and patients in the HRG.

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Section: Discussionmentioning

confidence: 99%