Lymph nodes from HIV-infected individuals harbor mature dendritic cells and increased numbers of PD-L1+ conventional dendritic cells

Carranza, Paloma; Estrada, Perla M. Del Río; Rivera, Dafne Díaz; Ablanedo-Terrazas, Yuria; Reyes‐Terán, Gustavo

doi:10.1016/j.humimm.2016.05.019

Cited by 7 publications

(13 citation statements)

References 46 publications

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“…Ex vivo tumour necrosis factor‐ α production by cDCs and pDCs was low but also increased following TLR activation. The LN pDCs needed TLR stimulation to produce measurable levels of IFN‐ α . In this study, the authors did not compare the functions of LN DCs from HIV‐1‐infected subjects with non‐infected controls, so limiting the extent of the findings.…”

Section: Dynamics Of Blood and Tissue Dcs During Hiv‐1 Infectionmentioning

confidence: 94%

“…While DC blood levels decrease during HIV/SIV infection these numbers were found at higher levels in lymphoid tissues from infected monkeys and humans, pointing to their recruitment into the lymphoid organs. As the disease progresses towards AIDS, however, SIV macaques display a depletion of DCs in LNs .…”

Section: Dynamics Of Blood and Tissue Dcs During Hiv‐1 Infectionmentioning

confidence: 96%

“…The ligands for PD‐1, namely PD‐L1 and PD‐L2, are expressed by DCs, macrophages and also B cells. PD‐L1 expression by cDCs in the LNs of HIV‐1‐infected individuals was observed, as well as macrophages . Studies of SIV‐infected macaques have shown that while PD‐L1 is increased on LN B cells, their expression of PD‐L2 is decreased compared with non‐infected animals .…”

Section: Alterations Of Gc B‐cell Impact On Tfh Cells During Hiv‐1 Inmentioning

confidence: 96%

“…Phenotypical studies of peripheral blood DCs have revealed that the levels of both cDCs (HLA‐DR + CD11c + ) and pDCs (HLA‐DR + CD123 + ) are decreased in HIV‐1‐infected subjects . Others showed that pDC levels were increased in non‐treated HIV‐1‐infected individuals with CD4 counts > 400 cells/μl, whereas they declined strongly in patients with AIDS .…”

Section: Dynamics Of Blood and Tissue Dcs During Hiv‐1 Infectionmentioning

confidence: 99%

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From dendritic cells to B cells dysfunctions during HIV‐1 infection: T follicular helper cells at the crossroads

2017

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Summary T follicular helper (Tfh) cells are essential for B‐cell differentiation and the subsequent antibody responses. Their numbers and functions are altered during human and simian immunodeficiency virus (HIV/SIV) infections. In lymphoid tissues, Tfh cells are present in germinal centre, where they are the main source of replicative HIV‐1 and represent a major reservoir. Paradoxically, Tfh cell numbers are increased in chronically infected individuals. Understanding the fate of Tfh cells in the course of HIV‐1 infection is essential for the design of efficient strategies toward a protective HIV vaccine or a cure. The purpose of this review is to summarize the recent advance in our understanding of Tfh cell dynamics during HIV/SIV infection. In particular, to explore the possible causes of their expansion in lymphoid tissues by discussing the impact of HIV‐1 infection on dendritic cells, to identify the molecular players rendering Tfh cells highly susceptible to HIV‐1 infection, and to consider the contribution of regulatory follicular T cells in shaping Tfh cell functions.

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Section: Dynamics Of Blood and Tissue Dcs During Hiv‐1 Infectionmentioning

confidence: 94%

Section: Dynamics Of Blood and Tissue Dcs During Hiv‐1 Infectionmentioning

confidence: 96%

Section: Alterations Of Gc B‐cell Impact On Tfh Cells During Hiv‐1 Inmentioning

confidence: 96%

Section: Dynamics Of Blood and Tissue Dcs During Hiv‐1 Infectionmentioning

confidence: 99%

See 2 more Smart Citations

From dendritic cells to B cells dysfunctions during HIV‐1 infection: T follicular helper cells at the crossroads

2017

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“…A number of diseases have been attributed to the deteriorated functions of DCs, including the differentiation, maturation, and motility of DCs, and their capacities of antigen capture, processing, and presentation. Thus, DC-targeted or -based immunotherapies have been exploited for the treatment of immune-associated diseases [2,3,4,5,6]. …”

Section: Introductionmentioning

confidence: 99%

Biophysical Properties and Motility of Human Mature Dendritic Cells Deteriorated by Vascular Endothelial Growth Factor through Cytoskeleton Remodeling

Xue

Long

et al. 2016

IJMS

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Dendritic cells (DCs), the most potent antigen-presenting cells, play a central role in the initiation, regulation, and maintenance of the immune responses. Vascular endothelial growth factor (VEGF) is one of the important cytokines in the tumor microenvironment (TME) and can inhibit the differentiation and functional maturation of DCs. To elucidate the potential mechanisms of DC dysfunction induced by VEGF, the effects of VEGF on the biophysical characteristics and motility of human mature DCs (mDCs) were investigated. The results showed that VEGF had a negative influence on the biophysical properties, including electrophoretic mobility, osmotic fragility, viscoelasticity, and transmigration. Further cytoskeleton structure analysis by confocal microscope and gene expression profile analyses by gene microarray and real-time PCR indicated that the abnormal remodeling of F-actin cytoskeleton may be the main reason for the deterioration of biophysical properties, motility, and stimulatory capability of VEGF-treated mDCs. This is significant for understanding the biological behavior of DCs and the immune escape mechanism of tumors. Simultaneously, the therapeutic efficacies may be improved by blocking the signaling pathway of VEGF in an appropriate manner before the deployment of DC-based vaccinations against tumors.

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The Lymph Node in HIV Pathogenesis

Dimopoulos¹,

Moysi²,

Petrovas³

2017

Curr HIV/AIDS Rep

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Lymph nodes play a central role in the development of adaptive immunity against pathogens and particularly the generation of antigen-specific B cell responses in specialized areas called germinal centers (GCs). Lymph node (LN) pathology was recognized as an important consequence of human immunodeficiency virus (HIV) infection since the beginning of the HIV epidemic. Investigation into the structural and functional alterations induced by HIV and Simian immunodeficiency virus (SIV) has further cemented the central role that lymphoid tissue plays in HIV/SIV pathogenesis. The coexistence of constant local inflammation, altered tissue architecture, and relative exclusion of virus-specific CD8 T cells from the GCs creates a unique environment for the virus evolution and establishment of viral reservoir in specific GC cells, namely T follicular helper CD4 T cells (Tfh). A better understanding of the biology of immune cells in HIV-infected lymph nodes is a prerequisite to attaining the ultimate goal of complete viral eradication.

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Lymph nodes from HIV-infected individuals harbor mature dendritic cells and increased numbers of PD-L1+ conventional dendritic cells

Cited by 7 publications

References 46 publications

From dendritic cells to B cells dysfunctions during HIV‐1 infection: T follicular helper cells at the crossroads

From dendritic cells to B cells dysfunctions during HIV‐1 infection: T follicular helper cells at the crossroads

Biophysical Properties and Motility of Human Mature Dendritic Cells Deteriorated by Vascular Endothelial Growth Factor through Cytoskeleton Remodeling

The Lymph Node in HIV Pathogenesis

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