Lymph node tuberculosis in patients from regions with varying burdens of tuberculosis and human immunodeficiency virus (HIV) infection

Clevenbergh, Philippe; Maitrepierre, Isabelle; Simoneau, Guy G.; Raskine, Laurent; Magnier, Jean-Dominique; Sanson-Le-Pors, Marie-José; Bergmann, Jean‐François; Sellier, Pierre

doi:10.1016/j.lpm.2010.02.055

Cited by 8 publications

(3 citation statements)

References 27 publications

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“…TB clinical-ultrasound-radiological suspicions were confirmed by histopathological examination, obtained by excisional biopsy of the sovraclavear lymph node, and also by culture and polymerase chain reaction (PCR), recommended as the gold standards for TB lymphadenopathy diagnosis [18,22]. The diagnosis was also supported by ADA and Quantiferon-Tb assays.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, while TB lymphadenitis is more frequently a clinical sign of disseminated diseases or of latent TB reactivation [2,18], in this rare case the sovraclavear and mediastinal TB lymphadenitis was not associated with other areas in the body, and , particularly not to lung lesions which is more commonly seen in HIV-positive patients [13]. In the case of isolated adenopathies, after exclusion of malignant causes, TB diagnosis should always be considered, especially in people from developing countries, and confirmed by microbiological examination, first by culture.…”

Section: Discussionmentioning

confidence: 99%

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Chest tuberculosis with mediastinal asymptomatic lymphadenitis without lung involvement in an immunocompetent patient

Pirina

Spada

Santoru

et al. 2013

J Infect Dev Ctries

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Tuberculosis remains the major cause of morbidity and mortality by a single infectious agent, particularly in developing countries. In recent years, we have witnessed the emergence of uncommon radiographic patterns of chest tuberculosis. Lymphadenitis is the most common extrapulmonary tuberculosis (TB) manifestation which, in developed countries, occurs more frequently in childhood, but also among adult immigrants from endemic countries and in HIV-infected people. Isolated and asymptomatic mediastinal lymphadenitis is uncommon in immunocompetent adults. We report a case of a young adult man from Senegal affected by sovraclavear and mediastinal TB lymphadenitis, which contains some uncommon elements: no compromised immunity, especially no HIV-infection, no lung lesions, no symptoms of infection or of mediastinum involvement, and rapid response to therapy in terms of mass size reduction. Examination of extra-thoracic lymph nodes and the patient's characteristics guided our diagnostic process to suspect TB. Surgical biopsy and subsequent histopathological and microbiological examinations of lymph material, first by Lowestein-Jensen and BACTEC cultures that remain the gold standard of diagnosis, confirmed the diagnosis. Chest X-ray was inconclusive; however, CT played an important role in the diagnostic course and in the management of the patient, particularly in determining disease activity, offering mediastinum and parenchymal details, as well as in identifying typical features of tuberculous lymph nodes and also of active/non active disease. Six months of antimycobacterial regimen is the recommended treatment in TB lymphadenitis of HIV-negative adults.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Chest tuberculosis with mediastinal asymptomatic lymphadenitis without lung involvement in an immunocompetent patient

Pirina

Spada

Santoru

et al. 2013

J Infect Dev Ctries

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“…Lymph node tuberculosis (formerly: scrophulosis) is the second, when it comes to the incidence, type of extrapulmonary tuberculosis ( 1 ) (in the population of HIV-positive patients – the first). The most commonly affected lymph nodes are: cervical lymph nodes, supraclavicular lymph nodes and finally inguinal lymph nodes ( 2 ) .…”

Section: Discussionmentioning

confidence: 99%

Isolated axillary lymph node tuberculosis in ultrasonography. A case report

Scieszka¹,

Urbańska-Krawiec²,

Kajor³

et al. 2012

J Ultrason

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We present a rare case of isolated axillary lymph node tuberculosis. A 66-year-old patient was admitted in order to perform the diagnostics of a painless tumor of the left armpit. Blood biochemistry tests and chest X-ray did not show any abnormalities. In the ultrasound examination a solid structure of the dimensions of 1.8×1 cm of irregular outline with adjacent hypoechogenic lymph nodes was visualized. The diagnosis of tuberculosis was based on histopathologic examination of the excised tumor. In the latter years an increase in extrapulmonary type of tuberculosis has been observed. Extrapulmonary tuberculosis may appear in practically each organ, nevertheless it affects pleura most often. Lymph node tuberculosis is the second, when it comes to the prevalence rate, type of extrapulmonary tuberculosis. In the majority of cases of lymph node tuberculosis it affects superficial lymph nodes. In the ultrasound examination a packet of pathological, enlarged and hypoechogenic lymph nodes is stated. In 1/3 of cases the central part of the nodes is hyperechogenic which indicates its caseation necrosis. Lymph nodes have a tendency to be matted and they have blurred outline. We observed this type of lymph node image in the presented patient. This image may be a diagnostic hint. Nevertheless, in the differentiation diagnostics one should take many other disease entities into consideration, inter alia: sarcoidosis, lymphomas, fungal infections, neoplastic metastases; the latter ones have an image most similar to tuberculosis lymph nodes. Tuberculosis ought to be considered in differential diagnosis of atypical masses.

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Extra Pulmonary Lymph Node, Abdominal and Pericardial Tuberculosis

Dedicoat

2021

Tuberculosis in Clinical Practice

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Lymph node tuberculosis in patients from regions with varying burdens of tuberculosis and human immunodeficiency virus (HIV) infection

Cited by 8 publications

References 27 publications

Chest tuberculosis with mediastinal asymptomatic lymphadenitis without lung involvement in an immunocompetent patient

Chest tuberculosis with mediastinal asymptomatic lymphadenitis without lung involvement in an immunocompetent patient

Isolated axillary lymph node tuberculosis in ultrasonography. A case report

Extra Pulmonary Lymph Node, Abdominal and Pericardial Tuberculosis

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