Lymph node retrieval in colorectal cancer: determining factors and prognostic significance

Betge, Johannes; Harbaum, Lars; Pollheimer, Marion J.; Lindtner, Richard A.; Kornprat, Peter; Ebert, Matthias P.; Langner, Cord

doi:10.1007/s00384-017-2778-8

Cited by 48 publications

(65 citation statements)

References 39 publications

(80 reference statements)

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“…Interestingly, as in this paper, Asian race/ Pacific Island descent (presumably less obese than other races), younger age, higher stage of colon cancer, and right-side colon cancer had more compliance with ''12 RLN,'' which may reflect the fact that more lymph nodes are harbored in the mesentery of these certain populations. 20,21 Shulman's data also endorses the previous finding that the number of lymph nodes evaluated after surgical resection confers survival benefits for patients with stage II and III colon cancer. 21,22 However, for stage III colon cancer, Tsikitis argued that the total number of lymph nodes analyzed is not a prognostic indicator of cancer-specific and disease-free survival.…”

supporting

confidence: 57%

The Value of Commission on Cancer Accreditation: Improving Survival Outcomes by Enhancing Compliance with Quality Measures

Misra¹,

Ji²,

Yanala

et al. 2019

Ann Surg Oncol

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supporting

confidence: 57%

The Value of Commission on Cancer Accreditation: Improving Survival Outcomes by Enhancing Compliance with Quality Measures

Misra¹,

Ji²,

Yanala

et al. 2019

Ann Surg Oncol

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“…Colon and rectal cancer are globally the third most commonly diagnosed cancer in males and the second most common in females. They are thus a major contributor to cancer morbidity and mortality worldwide [1]. For colon cancer, surgery remains the mainstay treatment.…”

Section: Introductionmentioning

confidence: 99%

“…A higher number of retrieved lymph nodes seem to be an independent prognostic factor for improved survival. In colon cancer patients with lymph node metastases or in cases of inadequately sampled number of lymph nodes, adjuvant chemotherapy is recommended [1]. Other indications for adjuvant chemotherapy are pT4 stage, poorly differentiated tumors, vascular or perineural invasion, lymphangiosis carcinomatosa, positive resection margins, patient in ileus, tumor perforation and stage III or stage IV [11].…”

Section: Introductionmentioning

confidence: 99%

Comparison of a Five-Year Survival and Cancer Recurrence between Laparoscopically Assisted and Open Colonic Resections due to Adenocarcinoma—A Single Centre Experience

Janež

Škapin

2020

Medicina

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Background and objectives: When resecting colon adenocarcinoma, surgeons decide between the use of laparoscopically assisted and open surgery. Laparoscopic resection is known to have short-term benefits over an open operation. However, researchers are not as unified about the long-term findings. The aim of this research is to elaborate on five-year post-operative differences in survival and cancer recurrence between these two different approaches. Materials and methods: 74 enrolled patients were evaluated five years after a primary operation. We collected dates of deaths of deceased patients and time after operation of possible recurrences. Carcinoma staging was done by a pathologist after operation. Blood samples were taken before surgery in order to measure tumor markers (CA19-9 and CEA). Results: Survival after colonic adenocarcinoma surgery did not differ between the two different surgical approaches (p = 0.151). Recurrence of cancer was not associated with the type of operation (p = 0.532). Patients with recurrence had a 37.6 times greater hazard ratio of dying (95% CI: [12.0, 118]; p < 0.001). Advanced age adversely affected survival: patients aged <65 and ≥65 years had a 97%, and 57% survival rate, respectively. Patients with elevated tumor markers at operation had a 19.1 greater hazard ratio of dying (95% CI: [5.16, 70.4]; p < 0.001). Patients with different TNM stages did not have any statistically significant differences in survival (HRII = 2.49; 95% CI: [0.67, 9.30]; pII = 0.173) (HRIII = 2.18; 95% CI: [0.58, 8.12]; pIII = 0.246) or recurrence (p = 0.097). Conclusion: The obtained results suggest that laparoscopic resection of colon cancer is not inferior from an oncologic point of view and results in a similar long-term survival and disease-free interval. Recurrence of carcinoma, older age at initial operation and elevated tumor markers, above a pre-set threshold at operation, were found to be independent factors of lower survival. We believe that the obtained results will be of benefit when choosing treatment for colon adenocarcinoma.

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“…The study describes the management and outcomes of patients with resectable colon cancer in a community hospital in Argentina. An adequate lymphadenectomy, with 12 or more lymph nodes retrieved, was achieved in 72% of patients, which is not inferior to figures reported in randomized control trials and observational studies from Europe [21,22].…”

Section: Discussionmentioning

confidence: 49%

Real World Evidence: Treatment of Patients with NonMetastatic Colon Cancer in a Community Hospital in Argentina: A Retrospective Cohort Study

Itkin¹

2018

OAJCO

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Background: The addition of adjuvant chemotherapy (ACT) to the surgical treatment of locally advanced colon cancer (CC) was shown to reduce relapses in stage III disease, although it remains controversial in stage II. However, an underutilization of ACT in stage III patients was reported. Data on use of ACT in stage II and in older patients in the "real world" in developing countries are limited. We aimed to describe management and outcome of non-metastatic colon cancer patients in a community hospital in Argentina. Methods: We retrospectively reviewed clinical charts of 99 patients with non-metastatic CC admitted in our Department between 2007 and 2016 extracting data on surgical treatment and chemotherapy use. Results: Emergency surgery was performed in 36.2% of cases. Near 72% of patients had 12 or more lymph nodes examined. Adjuvant chemotherapy was delivered to 93.1% of patients with stage III, to 38.1% of patients with stage II disease, and to 94.1% of stage III patients older than 70 years. Ninety six percent of patients with stage III disease received oxaliplatin-based chemotherapy. Similar proportions (near 50%) of patients <70 and > 70 years completed chemotherapy. After the median follow up of 2.1 years, (Interquartile range, 1.4 to 4.4 years), 16.2% of patients had a relapse. Conclusion: A guideline-compliant lymphadenectomy and ACT were performed in the majority of patients with CC in the routine practice in a developing country. The proportion of emergency surgical interventions is high. High proportion of older patients received ACT, and its completion rate in this subgroup is similar to younger patients.

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Lymph node retrieval in colorectal cancer: determining factors and prognostic significance

Cited by 48 publications

References 39 publications

The Value of Commission on Cancer Accreditation: Improving Survival Outcomes by Enhancing Compliance with Quality Measures

The Value of Commission on Cancer Accreditation: Improving Survival Outcomes by Enhancing Compliance with Quality Measures

Comparison of a Five-Year Survival and Cancer Recurrence between Laparoscopically Assisted and Open Colonic Resections due to Adenocarcinoma—A Single Centre Experience

Real World Evidence: Treatment of Patients with NonMetastatic Colon Cancer in a Community Hospital in Argentina: A Retrospective Cohort Study

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