Lymph Node Metastasis in Cutaneous Head and Neck Squamous Cell Carcinoma

Silberstein, Eldad; Sofrin, Efrat; Bogdanov-Berezovsky, Alexander; Nash, M.; Segal, N

doi:10.1097/dss.0000000000000488

Cited by 29 publications

(33 citation statements)

References 11 publications

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“…Therefore, we did not perform SLNB aggressively for patients with T1 tumors. However, the present study and that of Silberstein et al . have demonstrated that harboring a T1 tumor is not risk‐free.…”

Section: Discussioncontrasting

confidence: 85%

“…Therefore, the risk–benefit ratio should be considered when performing SLNB for cSCC, especially in elderly patients. Silberstein et al . justifies the policy of not performing SLNB for patients with low T stage head and neck cSCC.…”

Section: Discussionmentioning

confidence: 99%

“…8 The present study demonstrated slightly higher survival rates, although the outcome remained poor (5-year survival rate of 56%). Many previous studies have investigated the applicability of SLNB for cSCC, [8][9][10][11][12][13][14][15] although there was no consensus that SLNB led to an obvious improvement in prognosis.…”

Section: Discussionmentioning

confidence: 99%

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Availability of sentinel lymph node biopsy for cutaneous squamous cell carcinoma

Maruyama

Tanaka

Fujisawa

et al. 2016

The Journal of Dermatology

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Cutaneous squamous cell carcinoma is the second common cutaneous cancer, especially in the elderly. Sentinel lymph node biopsy is generally performed in breast cancers and cutaneous melanomas to detect occult nodal metastases. The benefit of sentinel lymph node biopsy in improving cutaneous squamous cell carcinoma prognosis is doubtful. One hundred and sixty-nine patients who underwent treatment for cutaneous squamous cell carcinoma between 2004 and 2015, and who were followed up for at least 6 months or developed metastases within the follow-up period were included. Forty-nine patients underwent sentinel lymph node biopsy, whereas 120 patients did not, including 13 who exhibited clinical lymph node metastases before treatment. Of these 49 patients, nine (18.4%) presented with sentinel lymph node metastasis, which occurred after treatment in three (6.1%) of them (false-negative). Among the 107 patients who did not undergo lymph node biopsy, 12 (11.2%) developed post-treatment metastases. The metastasis-free and disease-specific survival rates were not significantly different in those who did or did not undergo sentinel lymph node biopsy. Patients with clinical lymph node metastases had a higher risk compared with those without. Patients with T2-T4 tumors had a higher risk compared with those with T1 tumors. When selecting for those with T2 tumors or greater, the same lack of relationship was observed. In conclusion, in this small retrospective cohort, in patients with cutaneous squamous cell carcinoma, there were no significant differences in metastasis-free and disease-specific survival rates between those who did or did not undergo sentinel lymph node biopsy, regardless of T staging.

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Section: Discussioncontrasting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

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Availability of sentinel lymph node biopsy for cutaneous squamous cell carcinoma

Maruyama

Tanaka

Fujisawa

et al. 2016

The Journal of Dermatology

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“…Множество проведенных исследований по изучению зако-номерностей роста и прогрессии опухолей кожи показа-ли, что чем выше содержание интегринов в опухоли, тем выше скорость ее инвазии и более выраженный ангиогенез [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20]. Суть этих исследований заключалась в сравнении количества интегринов на разных клонах одной и той же опухоли, с определением скорости роста, инвазии и мета-стазирования каждого из клонов с последующим сравне-нием их между собой.…”

Section: влияние интегринов на прогрессию опухолей кожиunclassified

“…Суть этих исследований заключалась в сравнении количества интегринов на разных клонах одной и той же опухоли, с определением скорости роста, инвазии и мета-стазирования каждого из клонов с последующим сравне-нием их между собой. Результаты всех исследований были схожими: клоны, имевшие самый быстрый и злокаче-ственный рост, показывали наибольшую экспрессию ин-тегринов по сравнению с менее агрессивными вариантами тех же опухолей [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20].…”

Section: влияние интегринов на прогрессию опухолей кожиunclassified

The Role Integrins in Invasii and Metastatic Skin of Malignant Tumors

Titov¹,

Ротин²,

Казаков³

et al. 2016

Zlokač. opuholi

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Роль интегринов в инвазии и метастазировании злокачественных опухолей кожиThe role integrins in invasii and metastatic skin of malignant tumors www.malignanttumours.org • № 1 -2016 г. (17) • MALIGNANT TUMOURS РезюмеЗлокачественные опухоли кожи занимают лидирующее место в онкологической заболеваемости во всем мире. На сегодняшний день, благодаря развитию молекулярной биологии и генетики, становится понятным, что данные опухоли гетерогенны, имеют разные биологические характеристики, что влияет на прогноз заболевания и выбор тактики лечения. К таким изменениям относятся рецепторы интегринов, различная экспрессия которых может влиять на процессы инвазии и метастазирования. Предлагаем обзор современного понимания влияния интергинов на прогрессию опухолей кожи и разработки новых подходов к противоопухолевой терапии. AbstractMalignant tumors of skin take the leading place in neoplastic incidence worldwide. Currently, concerning the development of molecular biology and genetics, it becomes clear that these tumors are heterogenic and have different biological characteristics that of prognostic and predictive significance. Various degree of integrin receptors expression, which can influence processes of an invasion and metastasis, belongs to such changes. We review the problem of modern understanding of the integrin's influence on skin tumor progression and development of new approaches for antineoplastic therapy application.

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The Role of the Sentinel Lymph Node Biopsy in the Treatment of Nonmelanoma Skin Cancer and Cutaneous Melanoma

Champsas

Papadopoulos

2020

Non-Melanoma Skin Cancer and Cutaneous Melanoma

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Lymph Node Metastasis in Cutaneous Head and Neck Squamous Cell Carcinoma

Abstract: Because of the relatively low incidence of cervical lymph node metastases in patients with CSCC of the head and neck, SLNB for clinically N0 patients is not justified.

Cited by 29 publications

References 11 publications

Availability of sentinel lymph node biopsy for cutaneous squamous cell carcinoma

Availability of sentinel lymph node biopsy for cutaneous squamous cell carcinoma

The Role Integrins in Invasii and Metastatic Skin of Malignant Tumors

The Role of the Sentinel Lymph Node Biopsy in the Treatment of Nonmelanoma Skin Cancer and Cutaneous Melanoma

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