Lymph node mapping in rabbit liver cancer with nanocarbon and methylene blue injecta

Li, Zhong

doi:10.1016/s1995-7645(13)60046-2

Cited by 2 publications

(2 citation statements)

References 10 publications

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“…In recent years, nanocarbon tracers have gradually matured for malignant melanoma, breast cancer, thyroid cancer, and some digestive malignant tumors[ 21 ]. Nanocarbon lymph node tracers can help surgeons to determine lymph node metastasis to a certain extent, and they can improve the effective removal of lymph nodes during surgery[ 8 , 24 ].…”

Section: Discussionmentioning

confidence: 99%

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Role of carbon nanotracers in lymph node dissection of advanced gastric cancer and the selection of preoperative labeling time

Zhao¹,

Shan²,

Gao³

et al. 2022

WJCC

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BACKGROUND The incidence of gastric cancer is high. The number of dissected lymph nodes was an independent factor affecting prognosis. Although preoperative labeling is helpful in lymph nodes resection, there are no guidelines for when to perform preoperative labeling. AIM To investigate the role of nanocarbon in lymph node dissection during gastrectomy, and to discuss the relationship between the timing of preoperative injection of carbon nanoparticles and the extent of lymph node dissection. METHODS A prospective analysis was performed on the clinical data of 307 patients with advanced gastric cancer who underwent laparoscopic surgery in the General Surgery Department of Weifang People’s Hospital between June 2018 and February 2021. The patients were randomly divided into experimental group and control group based on whether they received preoperative nanocarbon injection or not. The experimental group was divided into different groups according to the preoperative labeling time. The number of dissected lymph nodes and the number of lymph nodes with black staining were compared in each group after surgery, and the role of nanocarbon in the number of dissected lymph nodes, pathological staging, and the relationship with prognosis were discussed. RESULTS The average number of dissected lymph nodes in the experimental group was higher than that in the control group. In the experimental group, the number of lymph node dissections and number of black-staining lymph nodes in the nanocarbon-labeling group at 2 d and 1 d before surgery were higher than in the labeling group on the day before surgery ( P < 0.05). CONCLUSION Preoperative nanocarbon labeling can safely and effectively guide lymph node dissection. To improve the detection rate of lymph nodes is conducive to subsequent comprehensive anti-tumor therapy.

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Section: Discussionmentioning

confidence: 99%

“…Within a short time, it is taken up by the macrophages, accumulated in the lymph vessels, and remains in the lymph nodes due to its high lymphoid affinity. The lymph nodes are stained black, which serves the purpose of staining the draining lymph nodes near the tumor tissue[ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Role of carbon nanotracers in lymph node dissection of advanced gastric cancer and the selection of preoperative labeling time

Zhao¹,

Shan²,

Gao³

et al. 2022

WJCC

View full text Add to dashboard Cite

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Rabbit VX2 lung tumor models can form early nodal metastases

et al. 2019

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BackgroundThe rabbit squamous cell cancer line, VX2, has been used to generate various tumor models in rabbits. It is notable for its ability to generate nodal metastases. However, the timing and extent of nodal metastases vary by primary inoculation site and methodology. The development of metastases specifically in lung cancer models has not been well-described. We sought to characterize the generation of nodal metastases in rabbit transbronchial VX2 lung tumor models.MethodsRabbit VX2 lung tumor models were created in the right lung via transbronchial injection and serially imaged by computed tomography. Rabbits (n = 15) were sacrificed from between 5 and 24 days post-inoculation for collection of the ipsilateral and contralateral paratracheal lymph nodes. These underwent histopathological evaluation for metastases using hematoxylin and eosin as well as cytokeratin AE1/AE3 immunohistochemical staining.ResultsNodal metastases were detectable as early as 1 week after inoculation but were more prevalent with longer inoculation; all rabbits at > 2 weeks post-inoculation had nodal metastases. Contralateral metastases were in general seen later than ipsilateral metastases. Lymph node volume did not predict the likelihood of nodal metastases (p = 0.4 and p = 0.07 for ipsilateral and contralateral nodal metastases, respectively), but primary tumor volume was significantly associated with the likelihood of nodal metastases (p = 0.001 and p = 0.005 for ipsilateral and contralateral nodal metastases, respectively). Ipsilateral metastases were detectable at a tumor diameter of 1 cm; contralateral metastases were more variable but in general required a tumor diameter of 2 cm.ConclusionsRabbit transbronchial VX2 lung tumor models generate nodal metastases relatively early after inoculation. These results suggest such models may be valuable tools in the investigation of novel therapeutic modalities relevant for the treatment of both early-stage and locally advanced lung cancer.

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Lymph node mapping in rabbit liver cancer with nanocarbon and methylene blue injecta

Cited by 2 publications

References 10 publications

Role of carbon nanotracers in lymph node dissection of advanced gastric cancer and the selection of preoperative labeling time

Role of carbon nanotracers in lymph node dissection of advanced gastric cancer and the selection of preoperative labeling time

Rabbit VX2 lung tumor models can form early nodal metastases

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