Lymph node biopsy for diagnosis: A statistical study

Lee, Yeu‐Tsu N.; Terry, Roger; Lukes, Robert J.

doi:10.1002/jso.2930140108

Cited by 71 publications

(42 citation statements)

References 10 publications

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“…In the present study 62% cases were of non-neoplastic lesions which was comparable to the study of Sinclair et al (53%) and Yeutsu (60%) et al 4 In present study, among 174 peripheral L.N. biopsy, large no.…”

Section: Discussionsupporting

confidence: 91%

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Histopathological analysis of lymph nodes in patient with clinical lymphadenopathy - 266 cases

Patel

Jha

2016

Int J Res Med Sci

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Section: Discussionsupporting

confidence: 91%

“…3 Lymphadenopathy are either generalized or localized and signify. 4,5  Benign condition such as reactive hyperplasia, acute or chronic inflammation.  A primary malignancy of the lymphoid system like Hodgkin or Non-Hodgkin lymphoma.…”

Section: Introductionmentioning

confidence: 99%

Histopathological analysis of lymph nodes in patient with clinical lymphadenopathy - 266 cases

Patel

Jha

2016

Int J Res Med Sci

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“…Age has previously been recognised as the most important factor in predicting whether LA is due to a benign or malignant process (Lee et al, 1980). When one considers malignancies presenting with peripheral lymphadenopathy, there is a male predominance.…”

Section: Discussionmentioning

confidence: 99%

Rapid access multidisciplinary lymph node diagnostic clinic: analysis of 550 patients

et al. 2003

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Lymphadenopathy is common, affecting patients of all ages. The current referral pattern for investigating patients with lymphadenopathy varies widely with no universally practised pathway. Our institution set up a lymph node diagnostic clinic (LNDC) accepting direct referrals from primary care physicians. Details of clinical presentation and investigations were recorded prospectively. Between December 1996 and July 2001, 550 patients were referred (M: 203; F:347). The median age was 40 years (range 14 -90). The median time between initial referral and the first clinic visit was 6 days. Of 95 patients diagnosed to have malignant diseases, the median time from the first clinic visit to reaching malignant diagnosis was 15 days. Multivariate logistic regression analysis identified five significant predictors for malignant nodes: male gender (risk ratio (RR) ¼ 2.72; 95% confidence interval (CI): 1.63 -4.56), increasing age (RR ¼ 1.05; 95% CI: 1.04 -1.07), white ethnicity (RR ¼ 3.01; 95% CI: 1.19 -7.6) and sites of lymph nodes: supraclavicular region (RR ¼ 3.72; 95% CI: 1.52 -9.12) and X2 regions of lymph nodes (RR ¼ 6.41; 95% CI: 2.82 -14.58). Ultrasound and fine-needle aspiration cytology of palpable lymph nodes were performed in 154 and 289 patients, respectively. An accuracy of 97 and 84% was found, respectively. In conclusion, a multidisciplinary lymph node diagnostic clinic enables a rapid, concerted approach to a common medical problem and patients with malignant diseases were diagnosed in a timely fashion.

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“…[1][2][3][4][5][6][7][8][9][10][11] Not all patients with palpable lymph nodes require biopsy, and the finding of benign disease requiring no further treatment is common. 5,12,13 This has stimulated the development of clinical algorithms to assist the decision to carry out an open surgical biopsy, [14][15][16] though these have not found general application, perhaps because patients may be referred to any one of a large number of specialist clinics.…”

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confidence: 99%

Diagnostic Biopsy of Lymph Nodes of the Neck, Axilla and Groin: Rhyme, Reason or Chance?

Moor

Murray

Inwood

et al. 2008

annals

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INTRODUCTION Improving patient pathways of care is becoming increasingly important in the delivery of timely, appropriate surgical care. With this aim, we analysed the referral and management pathway of patients undergoing diagnostic superficial lymph node biopsy.PATIENTS AND METHODS A retrospective review of case notes of patients undergoing diagnostic superficial lymph node biopsy over 3 years, 1998-2000 at the Bradford Hospitals NHS Trust. Indication for surgical biopsy was based on clinical suspicion following assessment in the out-patient clinic for the majority, and arrangement of investigations as deemed appropriate. There were no clinical algorithms in use during the study period.RESULTS There was no evidence for the use of explicit protocols for referral or management. Biopsy was often delayed. Of 268 patients referred from primary care, referral was made to any of 14 hospital departments with 39% (105 of 268) attending more than one outpatient appointment, and 155 (41 of 268) attending more than one department. Eighteen percent (47 of 268) of patients were informed of their diagnosis within 6 weeks of referral and 42% (113 of 268) within 3 months of referral. Nine percent (24 of 268) underwent pre-operative fine needle aspiration cytology. Of patients with enlarged neck nodes, 29% (52/180) had examination of the upper aero-digestive tract.CONCLUSIONS The study supports the introduction of co-ordinated problem-based referral and management pathways for the management of patients with enlarged superficial lymph nodes supported by regular audits of practice.

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Lymph node biopsy for diagnosis: A statistical study

Cited by 71 publications

References 10 publications

Histopathological analysis of lymph nodes in patient with clinical lymphadenopathy - 266 cases

Histopathological analysis of lymph nodes in patient with clinical lymphadenopathy - 266 cases

Rapid access multidisciplinary lymph node diagnostic clinic: analysis of 550 patients

Diagnostic Biopsy of Lymph Nodes of the Neck, Axilla and Groin: Rhyme, Reason or Chance?

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