Lymph flow during increases in pulmonary blood flow and microvascular pressure in dogs

Grimbert, FA; Martin, Donald E.; Parker, James C.

doi:10.1016/0883-9441(89)90053-1

Cited by 7 publications

(15 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…As also pointed out by Aukland and Reed (2), prenodal lymph protein concentration might be higher than the interstitial concentration because of tissue manipulation during prenodal lymph vessel cannulation. And in fact, in the present study, the protein concentration was lower than that obtained by sampling postnodal pulmonary lymph (31) and fell in the lower range of prenodal pulmonary lymph values obtained in dogs and sheep (10,20,26).…”

Section: Exclusion Phenomenon In the Pulmonary Interstitiumcontrasting

confidence: 71%

Interstitial Exclusion of Albumin in Rabbit Lung Measured with the Continuous Infusion Method in Combination with the Wick Technique

Negrini¹,

Tenstad²,

Wiig³

2003

Microcirculation

View full text Add to dashboard Cite

show abstract

Section: Exclusion Phenomenon In the Pulmonary Interstitiumcontrasting

confidence: 71%

Interstitial Exclusion of Albumin in Rabbit Lung Measured with the Continuous Infusion Method in Combination with the Wick Technique

Negrini¹,

Tenstad²,

Wiig³

2003

Microcirculation

View full text Add to dashboard Cite

show abstract

“…Although the assumptions underlying the partition values chosen in this equation may not hold in conditions of very high pulmonary flow, we are using PC as an index of filtration pressure. There is evidence that this index is a reasonable measure whatever the value of pulmonary flow; even when the arteriovenous pressure difference is large, PC may remain the average midpoint filtration pressure over a wide range of vascular pressures (5). The partition of vascular resistance implied in Gaar's equation conforms with recent studies on the segmental distribution of pulmonary vascular resistance in young lambs.…”

Section: Abbreviationssupporting

confidence: 60%

Patent Ductus Arteriosus Increases Lung Fluid Filtration in Preterm Lambs

et al. 1991

View full text Add to dashboard Cite

ABSTRACT. Previous studies showed that increased pul-The DA is a fetal vascular channel that normally closes soon monary blood flow from a patent ductus arteriosus had after birth. If it remains patent, as it often does after premature little or no effect on the amount of fluid in the lungs of birth, blood flow from the aorta into the pulmonary artery mechanically ventilated preterm lambs. The purpose of increases as pulmonary vascular resistance decreases postnatally. this study was to examine the effect of a patent ductus A PDA is thus associated with increased pulmonary blood flow, arteriosus on lung vascular permeability and to see whether pulmonary blood pressure, and PLvED (1, 2). The presence of a increased pulmonary lymph flow might compensate for the PDA may cause pulmonary edema in premature infants with increased rate of fluid filtration. Using a model that allows respiratory distress (3,4). However, little information is available mechanical control of ductus patency, we studied the effects to demonstrate how the PDA adversely affects pulmonary fluid of increased pulmonary blood flow on lung vascular pres-balance. sures in six mechanically ventilated premature lambs at Several studies have examined the effects of increased pulmo-We nary blood flow on lung fluid balance in adult and mature measured lung lymph flow and protein concentrations in newborn animals (5-1 1). In some of these studies, the increase lymph and plasma to assess pulmonary vascular fluid in microvascular fluid filtration associated with increased pulfiltration and protein permeability. We studied each lamb monary blood flow was attributed to increased microvascular during sequential steady state periods, first with the ductus filtration pressure (5, 6, 1 1); in other studies, the increased open and then with it closed. When the ductus was open, filtration was thought to be the result of lung vascular recruitment pulmonary blood flow was twice what it was when the (7-10). There is some evidence that the capacity for vascular ductus was closed. Mean pulmonary artery pressure and recruitment and increased fluid filtration in the pulmonary cirleft ventricular end-diastolic pressure were greater with culation may be age dependent (10-13). Little information is the ductus open [40 +. 5 torr (5.3 f 0.7 kPa) and 8 f 3 available regarding the influence of increased perfusion on lung torr (1.1 f 0.4 kPa), respectively] than when it was closed fluid filtration in the presence of underlying pulmonary pathol-124 f 3 torr (3.2 f 0.4 kPa) and 4 f 2 torr (0.5 f 0.3 ogy (9, 14), and the relationship between blood flow and fluid kPa), respectively]. When the ductus was open, lymph flow dynamics in the immature lung is even more obscure. was 68% greater and lymph protein concentration was 17%We used an animal model of the PDA that enables us to study lower than when the ductus was closed. Lymph protein the effects of increased pulmonary blood flow on lung fluid clearance (lymph flow % lymph protein concentration/ balance in newborn sheep (1,2,15). Pr...

show abstract

“…The hypoxia-dependent increase in membrane permeability was observed in other microvascular districts such as myocardial capillaries (1) and in cultured endothelial cells (19). Furthermore, acute hypoxia (inspired O 2 fraction ϭ 0.10) was shown to cause an increase in the pulmonary lymph flow rate associated with an unchanged lymph-to-plasma pro-tein concentration ratio, these data being consistent with an increased pulmonary endothelial permeability (4). The increased permeability to albumin was also confirmed in a recent study on humans acutely exposed to an altitude of 4,350 m (6).…”

Section: Discussionmentioning

confidence: 54%

Pulmonary interstitial pressure and tissue matrix structure in acute hypoxia

Miserocchi

Passi

Negrini

et al. 2001

American Journal of Physiology-Lung Cellular and Molecular Phys

View full text Add to dashboard Cite

Pulmonary interstitial pressure was measured via micropuncture in anesthetized rabbits in normoxia and after breathing 12% O(2). In normoxia [arterial PO(2) = 88 +/- 2 (SD) mmHg], pulmonary arterial pressure and pulmonary interstitial pressure were 16 +/- 8 and -9.6 +/- 2 cmH(2)O, respectively. After 6 h of hypoxia (arterial PO(2) = 39 +/- 16 mm Hg), the corresponding values were 30+/-8 and 3.5+/-2.5 cm H(2)O (P<0.05). Pulmonary interstitial proteoglycan extractability, evaluated by hexuronate assay after 0.4 M guanidinium hydrochloride extraction, was 12.3, 32.4, and 60.6 microg/g wet tissue in normoxia and after 3 and 6 h of hypoxia, respectively, indicating a weakening of the noncovalent bonds linking proteoglycans to other extracellular matrix components. Gel filtration chromatography showed an increased fragmentation of chondroitin sulfate- and heparan sulfate-proteoglycans during hypoxic exposure, accounting for a loss of extracellular matrix native architecture and basement membrane structure. Gelatin zymography demonstrated increased amounts of the proteolytically activated form of gelatinase B (matrix metalloproteinase-9) after hypoxic exposure, providing evidence that the activation of proteinases may play a role in hypoxia-induced lung injury.

show abstract

Lymph flow during increases in pulmonary blood flow and microvascular pressure in dogs

Cited by 7 publications

References 0 publications

Interstitial Exclusion of Albumin in Rabbit Lung Measured with the Continuous Infusion Method in Combination with the Wick Technique

Interstitial Exclusion of Albumin in Rabbit Lung Measured with the Continuous Infusion Method in Combination with the Wick Technique

Patent Ductus Arteriosus Increases Lung Fluid Filtration in Preterm Lambs

Pulmonary interstitial pressure and tissue matrix structure in acute hypoxia

Contact Info

Product

Resources

About