Lyme Disease Presenting as Chronic Fatigue Syndrome

Shor, Samuel

doi:10.1300/j092v13n04_06

Cited by 3 publications

(6 citation statements)

References 45 publications

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“…Although the early stages of this complex infection are widely recognized and routinely treated, there are controversies surrounding the diagnosis and treatment of advanced multi-symptom "post-Lyme disease syndrome," "post-treatment Lyme disease syndrome" or "chronic Lyme disease" [2][3][4]. One of the most common symptoms is chronic fatigue [2,4,5], and some patients with "chronic Lyme disease" are initially diagnosed with another fatiguing illness, chronic fatigue syndrome (CFS) [6,7]. Like "chronic Lyme disease," CFS is also characterized by multiple symptoms and chronic infections [7][8][9][10], and chronic fatigue is one of the most characteristic symptoms in both of these chronic illnesses [2,[4][5][6][7]9].…”

Section: Discussionmentioning

confidence: 99%

“…One of the most common symptoms is chronic fatigue [2,4,5], and some patients with "chronic Lyme disease" are initially diagnosed with another fatiguing illness, chronic fatigue syndrome (CFS) [6,7]. Like "chronic Lyme disease," CFS is also characterized by multiple symptoms and chronic infections [7][8][9][10], and chronic fatigue is one of the most characteristic symptoms in both of these chronic illnesses [2,[4][5][6][7]9].…”

Section: Discussionmentioning

confidence: 99%

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Glycophospholipid Formulation with NADH and CoQ10 Significantly Reduces Intractable Fatigue in Western Blot-Positive ‘Chronic Lyme Disease’ Patients: Preliminary Report

Nicolson

Settineri

Ellithorpe³

2012

FFHD

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Background: An open label 8-week preliminary study was conducted in a small number of patients to determine if a combination oral supplement containing a mixture of phosphoglycolipids, coenzyme Q10 and microencapsulated NADH and other nutrients could affect fatigue levels in long-term, Western blot-positive, multi-symptom ‘chronic Lyme disease’ patients (also called ‘post-treatment Lyme disease’ or ‘post Lyme syndrome’) with intractable fatigue. Methods: The subjects in this study were 6 males (mean age = 45.1 ± 12.4 years) and 10 females (mean age = 54.6 ± 7.4 years) with ‘chronic Lyme disease’ (determined by multiple symptoms and positive Western blot analysis) that had been symptomatic with chronic fatigue for an average of 12.7 ± 6.6 years. They had been seen by multiple physicians (13.3 ± 7.6) and had used many other remedies, supplements and drugs (14.4 ± 7.4) without fatigue relief. Fatigue was monitored at 0, 7, 30 and 60 days using a validated instrument, the Piper Fatigue Scale.Results: Patients in this preliminary study responded to the combination test supplement, showing a 26% reduction in overall fatigue by the end of the 8-week trial (p< 0.0003). Analysis of subcategories of fatigue indicated that there were significant improvements in the ability to complete tasks and activities as well as significant improvements in mood and cognitive abilities. Regression analysis of the data indicated that reductions in fatigue were consistent and occurred with a high degree of confidence (R2 = 0.998). Conclusions: The combination supplement was a safe and effective method to significantly reduce intractable fatigue in long-term patients with Western blot-positive ‘chronic Lyme disease.’Keywords: Lyme disease, Lipid Replacement Therapy, NT Factor, mitochondria, chronic fatigue, NADH, coenzyme Q10

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Glycophospholipid Formulation with NADH and CoQ10 Significantly Reduces Intractable Fatigue in Western Blot-Positive ‘Chronic Lyme Disease’ Patients: Preliminary Report

Nicolson

Settineri

Ellithorpe³

2012

FFHD

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“…In Babesia infections patients can show mild-to-severe hemolytic anemia (probably correlating with the protozoan colonization of erythrocytes, which can be seen by experienced individuals in blood smears), and a normal to slightly depressed leukocyte count (Mylonakis, 2001). However, these symptoms are usually not seen in patients who have progressed to the chronic phase of the disease, which can be similar in presentation to CFS (Shor, 2006).…”

Section: Discussionmentioning

confidence: 99%

“…CFS patients have also been diagnosed with Lyme disease (Shor, 2006), and Eskow et al (2003) have found that the attachment of ticks and subsequent appearance of musculoskeletal signs and symptoms is associated with systemic Mycoplasma fermentans infections (Eskow et al, 2003), it was not unexpected that CFS patients with evidence of Borrelia burgdorferi infections would also show evidence of Mycoplasma species in their blood. What is interesting is that the predominant presence of Mycoplasma fermentans in the Borrelia burgdorferi-positive CFS patients is consistent with the finding of this species of Mycoplasma in ticks collected from the environment (Eskow et al, 2003).…”

Section: Discussionmentioning

confidence: 99%

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Chronic Fatigue Syndrome Patients Subsequently Diagnosed with Lyme Disease Borrelia burgdorferi: Evidence for Mycoplasma Species Coinfections

Nicolson¹,

Nicolson²,

Haier³

2008

WCFS

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Objective: We examined the blood of 48 North American chronic fatigue syndrome (CFS) patients subsequently diagnosed with Lyme disease (Borrelia burgdorferi infection) and compared these with 50 North American CFS patients without evidence of Borrelia burgdorferi infections for presence of Mycoplasma species coinfections using forensic polymerase chain reaction. Results: We found that 68.75% of Garth L. Nicolson and Nancy L. Nicolson are affiliated to the Institute for Molecular Medicine, Huntington Beach, CA. Joerg Haier is affiliated to CFS/Lyme patients show evidence of mycoplasma coinfections (odds ratio [OR] = 41.8; confidence limits [CL] = 11.3-155; and p < .001) compared with controls, whereas 50% of CFS patients without a diagnosis of Lyme disease show Mycoplasma coinfections (OR = 19.0; CL = 5.3-69; and p < .001) compared with controls. Because CFS patients without a diagnosis of Lyme disease have a high prevalence of one of four Mycoplasma species and a majority show evidence of multiple infections, we examined CFS/Lyme patients' blood for various Mycoplasma species. We found that CFS patients with Lyme disease mostly had single species Mycoplasma infections (OR = 31.7; CL = 8.6-116; and p < .001) with a preponderance of Mycoplasma fermentans infections (50% of patients; OR = 59.0; CL = 7.6-460; and p < .001), whereas the most commonly found Mycoplasma species in CFS patients without Lyme disease was Mycoplasma pneumoniae (34% of patients; OR = 14.94; CL = 3.3-69; and p < .001). Conclusions: The results indicate that a subset of CFS patients show evidence of infection with Borrelia burgdorferi, and a large fraction of these patients were also infected with Mycoplasma fermentans and to a lesser degree with other Mycoplasma species.

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Chronic Fatigue Syndrome Patients Subsequently Diagnosed with Lyme DiseaseBorrelia burgdorferi: Evidence forMycoplasmaSpecies Coinfections

Nicolson

Haier

2007

Journal of Chronic Fatigue Syndrome

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Lyme Disease Presenting as Chronic Fatigue Syndrome

Cited by 3 publications

References 45 publications

Glycophospholipid Formulation with NADH and CoQ10 Significantly Reduces Intractable Fatigue in Western Blot-Positive ‘Chronic Lyme Disease’ Patients: Preliminary Report

Glycophospholipid Formulation with NADH and CoQ10 Significantly Reduces Intractable Fatigue in Western Blot-Positive ‘Chronic Lyme Disease’ Patients: Preliminary Report

Chronic Fatigue Syndrome Patients Subsequently Diagnosed with Lyme Disease Borrelia burgdorferi: Evidence for Mycoplasma Species Coinfections

Chronic Fatigue Syndrome Patients Subsequently Diagnosed with Lyme DiseaseBorrelia burgdorferi: Evidence forMycoplasmaSpecies Coinfections

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