Lyme and associated tick-borne diseases: global challenges in the context of a public health threat

Perronne, Christian

doi:10.3389/fcimb.2014.00074

Cited by 30 publications

(36 citation statements)

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“…While Lyme disease is usually described as an infection due to B. burgdorferi sensu stricto, to B. afzelii and to B. garinii, Lyme-like diseases may be due to other species of Borrelia. They are rarely considered or tested for, and their antibiotic susceptibility profile is poorly studied [3,14,18]. Borrelia miyamotoi, phylogenetically close to relapsing fever borreliae, is now recognized as a cause of Lyme-like disease and relapsing fever in Asia, Europe and North America [14,18].…”

Section: Several Species Of Borreliae Are Pathogenic For Humansmentioning

confidence: 99%

“…Acute or chronic syndromes occurring after tick bite may be due, in part or in total, to pathogens other than Borrelia sp., some of them tick-transmitted, others transmitted through different mechanisms [3]. Other well-known tick-transmitted infections are human granulocytic anaplasmosis and babesiosis, a frequent parasitic infection of animals.…”

Section: Role Of Coinfections In the Persistence Of Signs And Symptomsmentioning

confidence: 99%

“…The role of persistent microorganisms in the pathophysiology of chronic syndromes following Lyme disease treated according to the current recommendations is still being debated [1][2][3]. The clinician has no diagnostic test to use in routine practice to check for the persistence of live Borreliae.…”

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confidence: 99%

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Critical review of studies trying to evaluate the treatment of chronic Lyme disease

Perronne

2015

La Presse Médicale

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Section: Several Species Of Borreliae Are Pathogenic For Humansmentioning

confidence: 99%

Section: Role Of Coinfections In the Persistence Of Signs And Symptomsmentioning

confidence: 99%

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Critical review of studies trying to evaluate the treatment of chronic Lyme disease

Perronne

2015

La Presse Médicale

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“…Incidence rates in Europe are lower in northern Europe compared to the southern parts of Central Europe, ranging from less than one case to around 350 per 100,000 population [2]. These numbers are likely an underestimate since case reporting is inconsistent and many infections go undiagnosed [3, 4]. …”

Section: Introductionmentioning

confidence: 99%

Education on tick bite and Lyme borreliosis prevention, aimed at schoolchildren in the Netherlands: comparing the effects of an online educational video game versus a leaflet or no intervention

et al. 2016

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BackgroundLyme disease or Lyme borreliosis (LB) is the most common tick-borne disease both in the United States and Europe. Children, in particular, are at high risk of contracting LB. Since child-specific educational tools on ticks, tick bites and LB are lacking, we developed an online educational video game. In this study, we compared the effectiveness of an online educational video game versus a newly developed leaflet aimed to improve prevention of tick bites and LB among Dutch schoolchildren.MethodsA total of 887 children, aged 9–13 years and attending the two final years of primary schooling, were recruited from 25 primary schools in June and July 2012. They were assigned through cluster randomization to one of three intervention groups: ‘game’ (22.4%), ‘leaflet’ (35.6%) or ‘control’ (41.9%). Prior to and directly following intervention, the children were asked to complete a short questionnaire. The main outcome measures were knowledge, perception (perceived susceptibility and importance) and preventive behavior in relation to tick bites and LB. Generalized linear mixed models were used to analyze the data.ResultsIn the game group, the leaflet group and the control group, knowledge about ticks and tick bites improved significantly. The game was also an effective tool for improving preventive behavior; the frequency of checking for ticks increased significantly. However, there were no significant differences in knowledge improvement between the interventions. The game outperformed the leaflet in terms of improving preventive behavior, whereas the frequency of tick checks increased significantly. But this frequency didn’t increase more than in the control group.ConclusionsThe positive knowledge effects observed in the control group suggests the presence of a mere measurement effect related to completion of the questionnaire. The game did not outperform the leaflet or control group on all outcome measures. Therefore, the game may be of value as a complementary role, in addition to other media, in child-specific public health education programs on ticks and LB.This trial was retrospectively registered on October 21, 2016 (trial registration number: ISRCTN15142369).Electronic supplementary materialThe online version of this article (doi:10.1186/s12889-016-3811-5) contains supplementary material, which is available to authorized users.

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“…2 These numbers are likely to be underestimates because case reporting is inconsistent 3 and many infections go undiagnosed. 4 Climate change may have contributed to a rapid increase in tick borne diseases, with migratory birds disseminating infected ticks. 5 Our common understanding of Lyme disease is that a tick bite is followed by the development of a classic rash pattern (erythema migrans).…”

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Lyme disease: time for a new approach?

Borgermans

Perronne

Balicer

et al. 2015

BMJ

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Lyme and associated tick-borne diseases: global challenges in the context of a public health threat

Cited by 30 publications

References 56 publications

Critical review of studies trying to evaluate the treatment of chronic Lyme disease

Critical review of studies trying to evaluate the treatment of chronic Lyme disease

Education on tick bite and Lyme borreliosis prevention, aimed at schoolchildren in the Netherlands: comparing the effects of an online educational video game versus a leaflet or no intervention

Lyme disease: time for a new approach?

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