Lycorine: A prospective natural lead for anticancer drug discovery

Roy, Mridul; Liang, Long; Xiao, Xiaojuan; Feng, Peifu; Ye, Mao; Liu, Jing

doi:10.1016/j.biopha.2018.07.147

Cited by 114 publications

(87 citation statements)

References 144 publications

(176 reference statements)

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“…Based on the experience gained during the SARS epidemic, we selected plants that are effective before or at the initial stage of infection. Roy et al suggested a number of medicinal plants with these properties, although most of them grow in warm and hot areas, but there are plants found in Northeast Asia [ 11 ].…”

Section: Resultsmentioning

confidence: 99%

“…( Amaryllidaceae ) originally grew in China, Korea and Nepal and was later distributed to other countries, including Russia. It is a source of pharmacologically active alkaloids, with lycorine being the main one [ 11 , 23 , 24 , 25 , 26 ]. Lycorine has selective antiviral activity, including against severe acute respiratory syndrome associated with coronavirus and influenza virus [ 11 , 21 , 27 ].…”

Section: Resultsmentioning

confidence: 99%

“…Plants from traditional Chinese medicine are rich sources of compounds used for the development of medicines for a wide range of diseases (from coughs and colds to parasitic infections and inflammations) [ 10 , 11 , 12 ]. Chinese scientists were the first to search for medicinal plants against a new coronavirus infection.…”

Section: Introductionmentioning

confidence: 99%

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Medicinal Plants to Strengthen Immunity during a Pandemic

et al. 2020

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The development of new effective anti-coronavirus drugs and therapies is important, but it requires significant human, financial and, most importantly, time expenditures. The current pandemic is neither the first nor the last. Humanity has already accumulated considerable survival experience. We cannot do without prevention and epidemiological protection measures. This study reviews medicinal plants that grow in Northeast Asia and whose antioxidant, antiviral, anti-inflammatory and immunomodulatory characteristics are already known, also in the framework of the prevention and treatment of pneumonia of various etiologies. The need for a comprehensive approach to maintaining immunodefences, including functional foods and positive emotions, is emphasized. In the period of pandemics, it is important to research various areas that allow to us accumulate a critical mass of information and cope with the next global disease.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Medicinal Plants to Strengthen Immunity during a Pandemic

et al. 2020

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“…Lycorine, which is an antitumor compound, has attracted attention for research recently. Lycorine is an isoquinoline alkaloid in Amaryllidaceae, which has antitumor, antibacterial, antiviral, diuretic and cardiovascular effects [1][2][3]. In recent years, the antitumor effect of lycorine has become a hot topic.…”

Section: Introductionmentioning

confidence: 99%

Effect of lycorine on the structure and function of hepatoma cell membrane in vitro and in vivo

Xin

et al. 2020

Biotechnology & Biotechnological Equipment

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Lycorine is an isoquinoline alkaloid in Amaryllidaceae with antitumor, antibacterial, antiviral, diuretic and cardiovascular effects. This study explored the antitumor mechanism of lycorine in vitro and in vivo by focusing on its effects on tumor cell membrane fraction and tumor cell membrane structure. The results showed that lycorine had antitumor effect on H22 tumor-bearing mice in vivo and could effectively prolong the survival time of H22 tumor-bearing mice. In vitro, lycorine inhibited the proliferation of HepG-2 cells and induced cell death significantly. Lycorine reduced the total protein content, sialic acid content and cholesterol content on the surface of tumor cell membrane, and reduced the content of some main components of tumor cell membranes. Lycorine reduced the membrane fluidity and cell membrane integrity of tumor cells. In addition, the ion channel (Na þ , K þ-ATPase, Ca 2þ , Mg 2þ-ATPase) activity on the surface of the tumor cell membrane decreased. This contributed to a significant antitumor effect in vitro and in vivo.

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“…The continuously increasing interest in Amaryllidaceae alkaloids in the last years is based on important pharmaceutical properties. Galanthamine possesses anti-acetylcholinesterase activity, used for the treatment of Alzheimer’s disease, and is approved for use in the European Union and the United States [ 16 ]; lycorine possesses cytotoxicity and antitumor properties [ 17 ]; montanine possesses anxiolytic, antidepressant and anticonvulsive activities as well as immunomodulatory properties [ 18 ]; pancratistatin and narciclasine possess antitumor activity [ 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Recent Progress in Amaryllidaceae Biotechnology

2020

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Plants belonging to the monocotyledonous Amaryllidaceae family include about 1100 species divided among 75 genera. They are well known as medicinal and ornamental plants, producing pharmaceutically important alkaloids, the most intensively investigated of which are galanthamine and lycorine. Amaryllidaceae alkaloids possess various biological activities, the most important one being their anti-acetylcholinesterase activity, used for the treatment of Alzheimer’s disease. Due to increased demand for Amaryllidaceae alkaloids (mainly galanthamine) and the limited availability of plant sources, in vitro culture technology has attracted the attention of researchers as a prospective alternative for their sustainable production. Plant in vitro systems have been extensively used for continuous, sustainable, and economically viable production of bioactive plant secondary metabolites. Over the past two decades, a significant success has been demonstrated in the development of in vitro systems synthesizing Amaryllidaceae alkaloids. The present review discusses the state of the art of in vitro Amaryllidaceae alkaloids production, summarizing recently documented plant in vitro systems producing them, as well as the authors’ point of view on the development of biotechnological production processes with a focus on the future prospects of in vitro culture technology for the commercial production of these valuable alkaloids.

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Lycorine: A prospective natural lead for anticancer drug discovery

Cited by 114 publications

References 144 publications

Medicinal Plants to Strengthen Immunity during a Pandemic

Medicinal Plants to Strengthen Immunity during a Pandemic

Effect of lycorine on the structure and function of hepatoma cell membrane in vitro and in vivo

Recent Progress in Amaryllidaceae Biotechnology

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