LYCOPODIUM ALLERGY<sup>1</sup>

Salén, Ernst B.

doi:10.1111/j.1398-9995.1951.tb03422.x

Cited by 12 publications

(2 citation statements)

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“…[ 41 ] Previous reports indicate that L. clavatum allergies are very rare and in clinical cases are never diagnosed due to a lack of allergenic symptoms. [ 42 ] In particular, a review of 61 clinical cases of rhinitis or skin reactions associated with L. clavatum extracts indicates that the majority of cases were weakly positive and without clinical significance. [ 42 ] In our study, the L. clavatum spore based formulations Results are the mean of three batches ( n = 3) with standard deviation;…”

Section: Macromolecular Encapsulation and Characterization Of Naturalmentioning

confidence: 98%

Lycopodium Spores: A Naturally Manufactured, Superrobust Biomaterial for Drug Delivery

Mundargi

Potroz

Park

et al. 2015

Adv Funct Materials

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Herein, the exploration of natural plant‐based “spores” for the encapsulation of macromolecules as a drug delivery platform is reported. Benefits of encapsulation with natural “spores” include highly uniform size distribution and materials encapsulation by relatively economical and simple versatile methods. The natural spores possess unique micromeritic properties and an inner cavity for significant macromolecule loading with retention of therapeutic spore constituents. In addition, these natural spores can be used as advanced materials to encapsulate a wide variety of pharmaceutical drugs, chemicals, cosmetics, and food supplements. Here, for the first time a strategy to utilize natural spores as advanced materials is developed to encapsulate macromolecules by three different microencapsulation techniques including passive, compression, and vacuum loading. The natural spore formulations developed by these techniques are extensively characterized with respect to size uniformity, shape, encapsulation efficiency, and localization of macromolecules in the spores. In vitro release profiles of developed spore formulations in simulated gastric and intestinal fluids have also been studied, and alginate coatings to tune the release profile using vacuum‐loaded spores have been explored. These results provide the basis for further exploration into the encapsulation of a wide range of therapeutic molecules in natural plant spores.

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