Lycopene Treatment Transposed Antidepressant-Like Action in Rats Provoked to Chronic Mild Stress

Abstract

The present study aimed at evaluating the effects of lycopene on CMS-induced depressive-like behavioral changes in Wistar rats. In present study, rodents were selected randomly and grouped in to seven groups. Each group consists of six animals. All the groups are subjected to chronic mild stress in an unpredictable manner except the control group, which is free from stress. Behavioral changes induced during chronic mild stress were assessed by conducting the behavioral tests like forced swim test, sucrose preferences test, elevated plus maze test and open field tests in screening depressant and anxiety activity. The data analysis showed chronic mild stress produced depressive and anxiogenic behavior in the experimental rats. A significant increase in the immobility time and decrease in sucrose consumption in sucrose preference test are noted in CMS and vehicle groups. Similarly, in an elevated plus maze a significant decrease in the entries in the open arm and decrease in central square entries, and rearing behavior and increase in the duration of immobility were observed in open field test.Lycopene treatment for 6-weeks significantly decreased immobility time and increased in sucrose consumption observed in the forced swim test and sucrose preference test respectively. Lycopene significantly increased number of entries in the open arm of elevated plus maze and decreased grooming and freezing behavior in open field method. lycopene supplemented dose of 5mg/kg showed an insignificant results in all the behavioral models (p>0.05).The data were expressed as Mean±SD.Data were analyzed and differences between the means were determined by one-way analysis of variance (ANOVA) Using graph pad prism version 5.03 statistical software. In all the tests, differences were considered significant if p<0.05 to be a statistical significant. lycopene possesses antidepressant and mild- anxiolytic activity which may be due to its antioxidant effect that might warrant further studies.

Role of Nanolycopene Emulsion on the Submandibular Salivary Glands of Rats Exposed to Chronic Stress (Histological, Ultrastructural and Immunohistochemical Study)

“…Similarly, both histological and ultrastructural examination revealed that the SMG regained its almost normal architecture along with marked enhancement in cellular shape and component of the acini and ducts. The beneficial role of nanolycopene emulsion in improving CUMS-altered SMGs matched that of Kumar et al who evaluated the effects of lycopene on CUMS-induced depressive-like behavioral changes in rats and stated that lycopene possessed antidepressant activity which may be due to its antioxidant effect [32]. Noteworthy, Paruchuri et al reported that lycopene supplementation in rats exposed to CUMS significantly reversed the oxidative stress by increasing the antioxidant enzymes activity including; superoxide dismutase, catalase and glutathione peroxidase enzymes thereby raising the efficiency of antioxidant defense system [31] .…”

Antioxidant and Anti-Inflammatory Effects of Carotenoids in Mood Disorders: An Overview

“…Depression has a multifactorial etiology comprising functional deficits in monoamine, such as serotonin, and disturbances in the brain’s hypothalamic–pituitary–adrenal (HPA) axis [ 14 ]. In addition, emotional disorders such as anxiety and depression are often associated with a reduction in the activity of antioxidant enzymes in the HPA axis.…”