Lycopene mitigates pulmonary emphysema induced by cigarette smoke in a murine model

Campos, Keila Karine Duarte; Ramos, Camila de Oliveira; Martins, Thais Lourenço; Costa, Guilherme de Paula; Talvani, André; García, Camila; Oliveira, Laser Antônio Machado; Cangussú, Sílvia Dantas; Costa, Daniela Caldeira; Bezerra, Frank Silva

doi:10.1016/j.jnutbio.2018.12.008

Cited by 40 publications

(29 citation statements)

References 59 publications

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“…Within the two groups that were given a dose of lycopene, half was exposed to 60 days of cigarette smoke, and the other was not. The study found an increased number of circulating inflammatory cells and increased levels of inflammatory cytokines (p <0.05) in the group that was exposed to cigarette smoke (14). In contrast, there was a reduction in the number of total leukocytes, reduced cytokines, and improved pulmonary emphysema among the lycopene administered mice as determined by the number of macrophages, neutrophils, lymphocytes, and inflammatory cytokines (14).…”

Section: Chapter Onementioning

confidence: 90%

“…In summary, lycopene promoted a reduction in the number of total leukocytes and improved pulmonary emphysema. The authors also observed minimized redox processes due to a decrease in lipid peroxidation and DNA damage and an increase in the activities of superoxide dismutase (SOD), catalase (CAT), and GSH content (14).…”

Section: Chapter Onementioning

confidence: 93%

“…Additionally, it has been noted that nearly 90% of all COPD patients are smokers (4). Moreover, tobacco use is currently the single most significant and most preventable cause of illness and death in the world, killing approximately 6 million people a year (14). Cigarette smoke is a major source of oxidants, containing an estimated 10 18 spins (electron spin resonance) per gram of tar (particulate matter which is generated by burning tobacco) (4).…”

Section: Chapter Onementioning

confidence: 99%

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Association of Carotenoid Intake with Pulmonary Function

Jun

Root

2020

Journal of the American College of Nutrition

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Lung function gradually declines as adults age, which can make breathing more difficult. Previous studies have reported enhanced lung function among older adults with high intake of carotenoid-rich foods. The aim of this study is to investigate the association between carotenoid-rich diet and lung function. Data were taken from the Atherosclerosis Risk in Communities (ARIC) study, which included approximately 15,000 individuals aged 45-64 years at baseline from each of four counties in the United States. Food frequency questionnaire (FFQ) data were used to assess dietary intake of carotenoid-rich foods. Total carotenoids intake was calculated by adding five specific carotenoids-α-carotene, β-carotene, β-cryptoxanthin, lycopene, and lutein/zeaxanthin. Pulmonary function was evaluated as the ratio of forced expiratory volume in one second [FEV1] and forced vital capacity [FVC]. Linear regression analysis was used to assess the association between intake of carotenoids and pulmonary function. The association between the total carotenoid intake with pulmonary function was marginally positively significant; however, α-carotene, β-carotene, and β-cryptoxanthin intakes were individually significantly associated with a higher FEV1/FVC ratio in study participants. Dietary sources of pro-vitamin A carotenoids include yellow/orange fruits and vegetables such as oranges and sweet potatoes. Higher intake of these foods may improve pulmonary function.

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Section: Chapter Onementioning

confidence: 90%

Section: Chapter Onementioning

confidence: 93%

Section: Chapter Onementioning

confidence: 99%

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Association of Carotenoid Intake with Pulmonary Function

Jun

Root

2020

Journal of the American College of Nutrition

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“…Our OxyBlot analysis showed a marked increase in carbonyl groups introduced into protein side chains within the cells exposed to smoke, which verified our in vitro model of cigarette smoke exposure. Mounting evidence from in vitro and in vivo studies shows that lycopene and its metabolites have antioxidant and anti-inflammatory properties against carcinogen-induced lung lesions [15,[40][41][42] by inhibiting lipid peroxidation, DNA damage, production of inflammatory cytokines (i.e., TNFα, IFNγ, IL-10) [22,23], and enhancing the activities of two major antioxidant enzymes, superoxide dismutase and catalase [41,42].…”

Section: Discussionmentioning

confidence: 99%

Lycopene Protects against Smoking-Induced Lung Cancer by Inducing Base Excision Repair

et al. 2020

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Background: Oxidative stress plays a critical role in lung cancer progression. Carotenoids are efficient antioxidants. The objective of this study was to explore the efficacy of all-trans retinoic acid (ATRA) and carotenoids in cigarette smoke-induced oxidative stress within A549 human lung cancer epithelial cells. Methods: A549 cells were pretreated with 1-nM, 10-nM, 100-nM, 1-μM and 10-μM ATRA, β-carotene (BC) and lycopene for 24 h, followed by exposure to cigarette smoke using a smoking chamber. Results: The OxyBlot analysis showed that smoking significantly increased oxidative stress, which was inhibited by lycopene at 1 nM and 10 nM (p < 0.05). In the cells exposed to smoke, lycopene increased 8-oxoguanine DNA glycosylase (OGG1) expression at 1 nM, 10 nM, 100 nM, and 1 μM (p < 0.05), but not at 10 μM. Lycopene at lower doses also improved Nei like DNA glycosylases (NEIL1, NEIL2, NEIL3), and connexin-43 (Cx43) protein levels (p < 0.05). Interestingly, lycopene at lower concentrations promoted OGG1 expression within the cells exposed to smoke to an even greater extent than the cells not exposed to smoke (p < 0.01). This may be attributed to the increased SR-B1 mRNA levels with cigarette smoke exposure (p < 0.05). Conclusions: Lycopene treatment at a lower dosage could inhibit smoke-induced oxidative stress and promote genome stability. These novel findings will shed light on the molecular mechanism of lycopene action against lung cancer.

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“…Both CS and the carcinogen NNK are known to cause inflammation in lung in vivo (2,13,14). Accumulating data from both in vitro and in vivo studies have implied that lycopene has important biological properties, including antioxidant and antiinflammatory effect (13,(15)(16)(17). We have previously demonstrated that lycopene was protective against NNKinduced pulmonary neoplastic lesions and CS-induced squamous metaplasia in ferrets (13,18).…”

Section: Introductionmentioning

confidence: 96%

Lycopene Inhibits Smoke-Induced Chronic Obstructive Pulmonary Disease and Lung Carcinogenesis by Modulating Reverse Cholesterol Transport in Ferrets

Rakić

Liu

Veeramachaneni

et al. 2019

Cancer Prevention Research

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Chronic obstructive pulmonary disease (COPD) and lung cancer share the same etiologic factor, cigarette smoking. Higher consumption of dietary lycopene has been associated with lower risks of COPD and lung cancer in smokers. We investigated whether lycopene feeding protects against COPD and lung cancer in ferrets, a nonrodent model that closely mimics cigarette smoke (CS)-induced chronic bronchitis, emphysema, and lung tumorigenesis in human. We also explored whether the protective effect of lycopene is associated with restoring reverse cholesterol transport (RCT), a key driver in persistent inflammation with CS exposure. Ferrets (4 groups, n ¼ 12-16/group) were exposed to a combination of tobacco carcinogen (NNK) and CS with or without consuming lycopene at low and high doses (equivalent to $30 and $90 mg lycopene/day in human, respectively) for 22 weeks. Results showed that dietary lycopene at a high dose significantly inhibited NNK/ CS-induced chronic bronchitis, emphysema, and preneoplastic lesions, including squamous metaplasia and atypical adenomatous hyperplasia, as compared with the NNK/CS alone (P < 0.05). Lycopene feeding also tended to decrease the lung neoplastic lesions. Furthermore, lycopene feeding significantly inhibited NNK/CS-induced accumulation of total cholesterol, and increased mRNA expression of critical genes related to the RCT (PPARa, LXRa, and ATP-binding cassette transporters ABCA1 and ABCG1) in the lungs, which were downregulated by the NNK/CS exposure. The present study has provided the first evidence linking a protective role of dietary lycopene against COPD and preneoplastic lesions to RCT-mediated cholesterol accumulation in lungs.

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Lycopene mitigates pulmonary emphysema induced by cigarette smoke in a murine model

Cited by 40 publications

References 59 publications

Association of Carotenoid Intake with Pulmonary Function

Association of Carotenoid Intake with Pulmonary Function

Lycopene Protects against Smoking-Induced Lung Cancer by Inducing Base Excision Repair

Lycopene Inhibits Smoke-Induced Chronic Obstructive Pulmonary Disease and Lung Carcinogenesis by Modulating Reverse Cholesterol Transport in Ferrets

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