Lycopene intake and the risk of erectile dysfunction in US adults: NHANES 2001–2004

Gao, Yue; Liu, Chunhui; Lu, Kai; Zhang, Lei; Mao, Weipu; Pan, Ke-Hao; Liang, Zichun; Sun, Chao; Chen, Ming

doi:10.1111/andr.13439

Cited by 3 publications

(2 citation statements)

References 23 publications

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“…The main limitation of this study is the use of a self-reported questionnaire method to assess ED, which may not accurately reflect the true prevalence of ED. However, the validity of the measurement in our study has been previously tested, and the prevalence of ED in our study was similar to previous reports, which increases our confidence in the results ( 22 , 34 , 35 ). We posit that self-reported experiences of ED may be more relevant for perceived social support than objectively assessed ED.…”

Section: Discussionsupporting

confidence: 91%

The relationship between social support and erectile dysfunction in middle-aged and older males

Hu,

Zhang,

Zhang

et al. 2024

Front. Public Health

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BackgroundErectile dysfunction (ED) is a prevalent condition that affects middle-aged and older men, impacting their sexual health and overall wellbeing. We aimed to investigate the relationship between social support and ED among this specific population.MethodsData were collected from the National Health and Nutrition Examination Survey. Social support was assessed through various dimensions, including emotional support, material support, and network support. Multivariate logistic regression was performed to examine the association between social support and ED, and a propensity-score-matched (PSM) analysis was further conducted.ResultsAmong 1938 middle-aged and older males in the United States, 49.9% had a history of ED. ED was more prevalent in older individuals and those with comorbidities such as hypertension, prostate disease, higher serum creatinine level, and mental problems. Males with lower social support scores had a higher weighted rate of ED (P < 0.001). After adjusting for multiple variables in logistic regression analysis, a higher social support score was associated with a 19% lower likelihood of ED (weighted odds ratio [OR] 0.81, 95% confidence interval [CI] 0.66–0.98, P = 0.032). The association remained consistent after propensity score matching (OR 0.80, 95% CI 0.66–0.98, P = 0.028).ConclusionSocial support appears to be associated with a reduced risk of ED in middle-aged and older men. Further research is needed to better understand this relationship and explore interventions that enhance social support, potentially leading to improved sexual health outcomes.

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Section: Discussionsupporting

confidence: 91%

The relationship between social support and erectile dysfunction in middle-aged and older males

Hu,

Zhang,

Zhang

et al. 2024

Front. Public Health

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“… 42–44 HDL-C also downregulates neutrophil/monocyte infiltration of the arterial wall media/intima. 45 In addition, the effects of inflammatory activation of LDL-C endothelial cells are inhibited by HDL-C, mainly by reducing the oxidation of LDL-C. 45 HDL-C also increases the expression of endothelial nitric oxide synthase, which acts as a vasodilator. 46 …”

Section: Discussionmentioning

confidence: 99%

Monocyte-to-high-density lipoprotein cholesterol ratio and the risk of erectile dysfunction: a study from NHANES 2001-2004

Wu,

Zhang,

Jiang

et al. 2024

Sexual Medicine

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Background The monocyte-to-high-density lipoprotein cholesterol ratio (MHR) has become a novel inflammation marker with a possible association with erectile dysfunction (ED); however, there are fewer studies exploring the association between MHR and ED. Aim This study sought to explore the association between MHR and ED. Methods This study population was drawn from participants in two 2-year cycles of the National Health and Nutrition Examination Survey (2001-2002 and 2003-2004). MHR was calculated as the ratio of monocyte count (103 cells/μL) to high-density lipoprotein cholesterol (mg/dL). The relationship between MHR and ED was explored using survey-weighted logistic regression models with MHR as a continuous variable and divided into tertiles (tertile 1 [T1]: <0.01; T2: 0.01-0.014; T3: >0.014). We also used a smooth curve fit (penalized spline method) to characterize the dose-response relationship between MHR and ED. In addition, subgroup analyses based on age, body mass index, smoking, hypertension, diabetes mellitus, and cardiovascular disease were performed to further analyze the data. Sensitivity analyses were also conducted to further assess the stability of the results. Outcomes The main outcome measure was the difference in ED prevalence between MHR levels. Results A total of 1361 participants were enrolled, with 513 (T1), 438 (T2), and 410 (T3) participants in the 3 MHR groups. After adjusting for all potential covariates, survey-weighted logistic regression analyses showed a significant association between MHR and ED (odds ratio [OR], 1.96; 95% confidence interval [CI], 1.26-3.05). When MHR was used as a categorical variable, the adjusted OR for ED prevalence increased significantly with increasing MHR after adjusting for all potential covariates (T3 vs T1: OR, 2.14; 95% CI, 1.29-3.55). The dose-response curves showed that the prevalence of ED increased with increasing MHR. Clinical Implications Easy to access and low cost, MHR is a convenient clinical tool that helps clinicians in the prevention and treatment of ED. Strengths and Limitations The present study is the first to examine the association between MHR and ED nationally representative data. However, the study population was derived from a U.S. database, so the findings are limited to the U.S. population. Conclusion Our study demonstrated that MHR levels were independently associated with ED and that ED patients had higher MHR levels, suggesting that MHR may be a valuable predictor for identifying people at higher risk for ED.

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Association between serum carotenoids and bacterial vaginosis infection among American women

Tan,

Feng,

Hong

et al. 2024

BMC Infect Dis

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Background Bacterial vaginosis (BV) is a widely occurring vaginal inflammation in women of childbearing age caused by dysbiosis of the vaginal flora. Few studies have investigated the effect of serum carotenoids on the development and pathogenesis of BV. This study thus aimed to explore the correlation between serum carotenoids and BV in American women. Method The analysis included 1252 participants with BV from the National Health and Nutrition Examination Survey (NHANES) between 2001 and 2004. Multiple logistic regression was conducted to explore the correlation between BV and serum carotenoids, while smooth curve fitting was utilized to examine potential nonlinear correlations. Furthermore, stratified subgroup analyses and sensitivity analyses were conducted. ORs reflected the correlation between BV and serum carotenoids. Result Results of multiple logistic regression indicated that total serum carotenoids and BV had an inverse correlation. In the fully adjusted model II, the quartile with the highest levels of α-carotene and β-cryptoxanthin had a substantially lower incidence of BV. Smooth curve fitting revealed a significant negative linear correlation between serum carotenoids and the incidence of BV. The negative correlation between serum carotenoids and BV was relatively stable in stratified analyses. Moreover, in sensitivity analyses, the association between serum carotenoids and BV persisted, and β-carotene became significantly negatively correlated with BV. Conclusion This study found an inverse correlation between serum carotenoids and the prevalence of BV.

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Lycopene intake and the risk of erectile dysfunction in US adults: NHANES 2001–2004

Cited by 3 publications

References 23 publications

The relationship between social support and erectile dysfunction in middle-aged and older males

The relationship between social support and erectile dysfunction in middle-aged and older males

Monocyte-to-high-density lipoprotein cholesterol ratio and the risk of erectile dysfunction: a study from NHANES 2001-2004

Association between serum carotenoids and bacterial vaginosis infection among American women

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