Lycopene Inhibits Propagation of Chlamydia Infection

Zigangirova, N. A.; Morgunova, Elena Y.; Fedina, Elena D.; Shevyagina, Natalia V.; Borovaya, Tatiana G.; Zhukhovitsky, V. G.; Kyle, Nigel H.; Petyaev, Ivan M.

doi:10.1155/2017/1478625

Cited by 10 publications

(6 citation statements)

References 27 publications

(26 reference statements)

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“…Moreover, decline in oxidized LDL and IOD values caused by GA lycopene supplementation was accompanied by a threefold reduction in Chlamydia pneumoniae IgG which is known to be an important marker of oxidative stress and inflammation in cardiovascular patients (Di Pietro, Filardo, Falasca, Turriziani, & Sessa, ). This observation is in a good agreement with our recently published results (Zigangirova et al., ) revealing a strong inhibitory effect of lycopene on C. trachomatis and C. pneumoniae infections in cultured cells. However, under the conditions used in our study, we did not observe any significant changes in the markers of oxidation and inflammation or in cardiovascular parameters for patients supplemented with lactolycopene, although there was a half‐fold increase in serum lycopene level in patients with cardiovascular disease after 1 month of supplementation.…”

Section: Discussionsupporting

confidence: 94%

Effect of lycopene supplementation on cardiovascular parameters and markers of inflammation and oxidation in patients with coronary vascular disease

Petyaev

Dovgalevsky

Klochkov

et al. 2018

Food Science & Nutrition

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Oxidative stress and antioxidant deficiency play a pivotal role in initiation, development, and outcomes of cardiovascular disease. Pharmacokinetic parameters as well as the impact of highly bioavailable lycopene on cardiovascular variables, markers of inflammation and oxidation were investigated during a 30‐day clinical trial in patients with coronary vascular disease. The patients were randomized into two major groups and were supplemented with a single 7 mg daily dose of lycopene ingested either in the form of lactolycopene (68 patients) or in the form of lycosome‐formulated GA lycopene (74 patients). The endpoints included cardiovascular function parameters, serum lipids, and four markers of oxidative stress and inflammation. Ingestion of lycosome‐formulated lycopene increased serum lycopene levels by 2.9‐ and 4.3‐fold, respectively, after 2 and 4 weeks of the trial, whereas supplementation with lactolycopene upregulated serum lycopene by half‐fold only after 4 weeks of ingestion. Lycosome formulation of lycopene resulted by the end of the trial in a threefold reduction in Chlamydia pneumoniae IgG and reduction to the same degree of the inflammatory oxidative damage marker. The decrease in oxidized LDL caused by lycosome‐formulated lycopene was fivefold. Moreover, supplementation with lycosome‐formulated lycopene was accompanied by a significant increase in tissue oxygenation and flow‐mediated dilation by the end of the observational period. In contrast, lactolycopene did not cause any significant changes in the parameters studied. Therefore, enhanced bioavailability of lycopene promotes its antioxidant and anti‐inflammatory functions and endorses a positive effect of lycopene on cardiovascular system.

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Section: Discussionsupporting

confidence: 94%

Effect of lycopene supplementation on cardiovascular parameters and markers of inflammation and oxidation in patients with coronary vascular disease

Petyaev

Dovgalevsky

Klochkov

et al. 2018

Food Science & Nutrition

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“…Intake of lycopene rich food has been linked to lower prevalence of cardiovascular disease, stroke [1] and some forms of cancer [2, 3]. Limited interventional clinical studies have indicated its therapeutic ability to slow down development of carotid atherosclerosis [4], anti-infective and anti-inflammatory properties [5], improvement of parameters associated with prostate hyperplasia [6], benefit in management of prostate cancer [7] and help to protect skin from UV damage [8, 9].…”

Section: Introductionmentioning

confidence: 99%

Prebiotic Effect of Lycopene and Dark Chocolate on Gut Microbiome with Systemic Changes in Liver Metabolism, Skeletal Muscles and Skin in Moderately Obese Persons

Wiese

Bashmakov

Chalyk

et al. 2019

BioMed Research International

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Lycopene rich food and dark chocolate are among the best-documented products with a broad health benefit. This study explored the systemic effect of lycopene and dark chocolate (DC) on gut microbiota, blood, liver metabolism, skeletal muscle tissue oxygenation and skin. 30 volunteers were recruited for this trial, 15 women and 15 men with a mean age of 55 ± 5.7 years and with moderate obesity, 30 < BMI < 35 kg/m2. They were randomized and divided into five equal interventional groups: three received different formulations of lycopene, one of them with a 7 mg daily dose and two with 30 mg; another group was given 10 g of DC with 7 mg lycopene embedded into its matrix, and the last group received 10 g DC. The trial was double-blinded for the three lycopene groups and separately for the 2 DC groups; the trial lasted for 1 month. By the end of the trial there were dose-dependent changes in the gut microbiota profile in all three lycopene groups with an increase of relative abundance of, e.g., Bifidobacterium adolescentis and Bifidobacterium longum. This was also accompanied by dose-dependent changes in the blood, liver metabolism, skeletal muscle and skin parameters. Consumption of DC resulted in increased relative abundance of, e.g., Lactobacillus and a reduction of corneocyte exfoliation. This is the first study which reports the prebiotic potential of lycopene and DC.

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“…Petyaev (2016) and Chen et al (2015), respectively, reported lycopene deficiency in ageing and prostate cancer in human. Zigangirova et al (2017) reported that lycopene inhibits propagation of Chlamydia red blood cells (RBC) osmotic fragility and lipid peroxidation in animals by lycopene. Moreover, Pandir et al (2016) reported the effect of lycopene at 4 and 40 mg/kg body weight against oxidative damage induced by furan.…”

Section: Introductionmentioning

confidence: 99%

Lycopene attenuates diabetes-induced oxidative stress in Wistar rats

Eze¹,

Afodun²,

Sulaiman³

et al. 2018

J. Diabetes Endocrinol.

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The purpose of this study is to evaluate the capacity of lycopene against diabetes-induced oxidative damage in Wistar rats. Thirty Wistar rats of both sexes, twenty-five of which were diabetic, were used. Diabetes was induced by a single intraperitoneal injection of streptozotocin (STZ) 60 mg/kg body weight and it was confirmed by the elevated blood glucose ≥200 mg/dl after three days. The rats were divided randomly into groups 1 to 6, each containing 5 rats. Group 1 (Normal control) and Group 2 (Diabetic control) rats were administered 0.5 ml of olive oil; Groups 3, 4, and 5 rats were respectively administered 10, 20 and 40 mg/kg body weight of lycopene, while Group 6 rats were administered 2 mg/kg body weight of Glibenclamide. All administrations were done orally and once daily for twentyeight days. At the end of the treatment, serum levels of antioxidant enzymes, cortisol and malondialdehyde (MDA) were determined. Administration of graded doses of lycopene to diabetic animals significantly (P<0.05) decreased the blood glucose concentration after four weeks of treatment when compared to diabetic untreated animals. Serum levels of cortisol and MDA (index of oxidative stress) were reduced while there were up-regulated activities of serum endogenous enzymes (superoxide dismutase, catalase and glutathione peroxidase) in diabetic animals treated with all doses of lycopene when compared with diabetic untreated animals. Overall, lycopene attenuated the biomedical alterations in STZ-induced diabetic Wistar rats. Lycopene therefore possesses antioxidant activity at the doses tested in this study.

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Lycopene Inhibits Propagation of Chlamydia Infection

Cited by 10 publications

References 27 publications

Effect of lycopene supplementation on cardiovascular parameters and markers of inflammation and oxidation in patients with coronary vascular disease

Effect of lycopene supplementation on cardiovascular parameters and markers of inflammation and oxidation in patients with coronary vascular disease

Prebiotic Effect of Lycopene and Dark Chocolate on Gut Microbiome with Systemic Changes in Liver Metabolism, Skeletal Muscles and Skin in Moderately Obese Persons

Lycopene attenuates diabetes-induced oxidative stress in Wistar rats

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