Lycopene in association with α-tocopherol or tomato lipophilic extracts enhances acyl-platelet-activating factor biosynthesis in endothelial cells during oxidative stress

Balestrieri, Maria Luisa; Prisco, Rocco De; Nicolaus, Barbara; Pari, Paola; Moriello, V.Schiano; Strazzullo, G.; Iorio, Eugenio Luigi; Servillo, Luigi; Balestrieri, Ciro

doi:10.1016/j.freeradbiomed.2004.01.014

Cited by 51 publications

(32 citation statements)

References 38 publications

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“…LDL susceptibility to oxidative modifications is decreased by an acyl analog of platelet-activating factor (PAF), acyl-PAF, which exerts its beneficial role during the initiation and progression of atherosclerosis. Purified lycopene in association with a-tocopherol or tomato lipophilic extracts has been shown to enhance acyl-PAF biosynthesis in endothelial cells during oxidative stress (Balestrieri et al, 2004). Fuhrman et al (2000) further reported comparative data in which tomato oleoresin exhibited superior capacity to inhibit in vitro LDL oxidation in comparison with pure lycopene, by up to fivefold.…”

Section: Mechanisms Of Action Of Lycopenementioning

confidence: 99%

Tomatoes versus lycopene in oxidative stress and carcinogenesis: conclusions from clinical trials

2006

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Objective: To review the effects of tomato product supplementation, containing lycopene, on biomarkers of oxidative stress and carcinogenesis in human clinical trials. Results: Supplementation of tomato products, containing lycopene, has been shown to lower biomarkers of oxidative stress and carcinogenesis in healthy and type II diabetic patients, and prostate cancer patients, respectively. Processed tomato products like tomato juice, tomato paste, tomato puree, tomato ketchup and tomato oleoresin have been shown to provide bioavailable sources of lycopene, with consequent increases in plasma lycopene levels versus baseline. Dietary fats enhance this process and should be consumed together with food sources of lycopene. The mechanisms of action involve protection of plasma lipoproteins, lymphocyte DNA and serum proteins against oxidative damage, and anticarcinogenic effects, including reduction of prostate-specific antigen, upregulation of connexin expression and overall decrease in prostate tumor aggressiveness. There is limited in vivo data on the health benefits of lycopene alone. Most of the clinical trials with tomato products suggest a synergistic action of lycopene with other nutrients, in lowering biomarkers of oxidative stress and carcinogenesis. Conclusions: Consumption of processed tomato products, containing lycopene, is of significant health benefit and can be attributed to a combination of naturally occurring nutrients in tomatoes. Lycopene, the main tomato carotenoid, contributes to this effect, but its role per se remains to be investigated.

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Section: Mechanisms Of Action Of Lycopenementioning

confidence: 99%

Tomatoes versus lycopene in oxidative stress and carcinogenesis: conclusions from clinical trials

2006

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“…Lycopene synergises with other natural compounds such as α-tocopherol and 1,25-dihydroxyvitamin D 3 in inhibiting prostate carcinoma cell proliferation, 56 HL-60 leucaemic cell differentiation 57 and low-density lipoprotein oxidation. 58 Moreover, the presence of lipids may enhance the bioavailability of carotenoids. 59,60 Hence the biochemical composition of the oleoresin was important to evidence the possible presence of other bioactive and synergistic molecules in the SC-CO 2 extract.…”

Section: Biochemical Characterisation Of Oleoresinmentioning

confidence: 99%

Optimisation of biological and physical parameters for lycopene supercritical CO2 extraction from ordinary and high-pigment tomato cultivars

Lenucci

Caccioppola

Durante

et al. 2010

J. Sci. Food Agric.

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“…The regular ingestion of an adequate amount of fresh tomatoes or tomato products has been inversely correlated to the development of some types of cancer (Agarwal and Rao, 1998) and to plasma lipid peroxidation (Giovannucci, 1999;Balestrieri et al, 2004). This protective effect has been mainly attributed to the carotenoid constituents of the fruits, particularly lycopene and bcarotene which act as antioxidants in detoxifying free radicals (Di Mascio et al, 1989;Stahl and Sies, 1996;Clinton, 1998).…”

Section: Introductionmentioning

confidence: 99%

Antioxidant activity and bioactive compound changes during fruit ripening of high-lycopene tomato cultivars

Ilahy¹,

Hdider²,

Lenucci

et al. 2011

Journal of Food Composition and Analysis

155

130

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Lycopene in association with α-tocopherol or tomato lipophilic extracts enhances acyl-platelet-activating factor biosynthesis in endothelial cells during oxidative stress

Cited by 51 publications

References 38 publications

Tomatoes versus lycopene in oxidative stress and carcinogenesis: conclusions from clinical trials

Tomatoes versus lycopene in oxidative stress and carcinogenesis: conclusions from clinical trials

Optimisation of biological and physical parameters for lycopene supercritical CO2 extraction from ordinary and high-pigment tomato cultivars

Antioxidant activity and bioactive compound changes during fruit ripening of high-lycopene tomato cultivars

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