Lycopene improves maternal reproductive performance by modulating milk composition and placental antioxidative and immune status

Sun, Shishuai; Meng, Qiang; Bai, Yongsong; Cao, Chunyu; Li, Jibo; Cheng, Baohua; Shi, Baoming; Shan, Anshan

doi:10.1039/d1fo01595h

Cited by 9 publications

(5 citation statements)

References 74 publications

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“…Zn-alpha2-glycoprotein (ZAG), via the cAMP/PKA signaling pathway, regulates sperm motility (Qu et al, 2007). Pigs have been used as an animal model to explore human nutrition because their physiology is to humans (O'Shea et al, 2015;Sun et al, 2021). In the current study, we discovered that TAX increased semen quality via the improvement of gut microbiota and systemic metabolome.…”

Section: Introductionmentioning

confidence: 62%

Taxifolin increased semen quality of Duroc boars by improving gut microbes and blood metabolites

et al. 2022

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Taxifolin (TAX), as a natural flavonoid, has been widely focused on due to its strong anti-oxidation, anti-inflammation, anti-virus, and even anti-tumor activity. However, the effect of TAX on semen quality was unknown. The purpose of this study was to analyze the beneficial influences of adding feed additive TAX to boar semen in terms of its quality and potential mechanisms. We discovered that TAX increased sperm motility significantly in Duroc boars by the elevation of the protein levels such as ZAG, PKA, CatSper, and p-ERK for sperm quality. TAX increased the blood concentration of testosterone derivatives, antioxidants such as melatonin and betaine, unsaturated fatty acids such as DHA, and beneficial amino acids such as proline. Conversely, TAX decreased 10 different kinds of bile acids in the plasma. Moreover, TAX increased “beneficial” microbes such as Intestinimonas, Coprococcus, Butyrivibrio, and Clostridium_XlVa at the Genus level. However, TAX reduced the “harmful” intestinal bacteria such as Prevotella, Howardella, Mogibacterium, and Enterococcus. There was a very close correlation between fecal microbes, plasma metabolites, and semen parameters by the spearman correlation analysis. Therefore, the data suggest that TAX increases the semen quality of Duroc boars by benefiting the gut microbes and blood metabolites. It is supposed that TAX could be used as a kind of feed additive to increase the semen quality of boars to enhance production performance.

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Section: Introductionmentioning

confidence: 62%

Taxifolin increased semen quality of Duroc boars by improving gut microbes and blood metabolites

et al. 2022

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“…The study showed that body weight (BW) and average daily gain (ADG) of fattening pigs were improved after adding lycopene (20 mg kg −1 ) to the diet for 4 weeks. 158 It was found that the production performance of hybrid fattening pigs was not affected after adding lycopene (12.5, 25.0, 37.5 and 50.0 mg kg −1 ) to their diets for 4 weeks. 159 This may be due to differences in pig breeds, feeding management, and other factors, resulting in various research results.…”

Section: Reviewmentioning

confidence: 96%

The sources, properties, extraction, biosynthesis, pharmacology, and application of lycopene

Wei,

Lin,

Adu

et al. 2023

Food Funct.

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“…Lycopene might work by encouraging T-cell transition, raising the CD4+/CD8+ ratio, and concurrently lowering inflammatory cytokine levels, all of which would enhance rats’ immunity ( 106 ). Moreover, lycopene could also ensure the health of the sow placenta by reducing the expression level of placental inflammatory factors and improving immunoglobulin content, antioxidant capacity, placental lipid transport, and lipid metabolism ( 16 ). Other studies have found that lycopene could regulate the efficiency of IFN-γ and IL-2 production by mouse T lymphocytes or indirectly activate T cells ( 108 ).…”

Section: Physiological Functions and Mechanisms Of Action Of Lycopenementioning

confidence: 99%

“…Currently, reports about lycopene are gradually increasing. Previous research has shown that lycopene improved animal production performance ( 16 ), maintained intestinal health ( 17 ), ameliorated meat quality ( 18 ), ameliorated immunity ( 19 ) and regulated body metabolism ( 20 ), and has good application prospects.…”

Section: Introductionmentioning

confidence: 99%

Physicochemical properties, mechanism of action of lycopene and its application in poultry and ruminant production

Long,

Paengkoum,

et al. 2024

Front. Vet. Sci.

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Lycopene is a kind of natural carotenoid that could achieve antioxidant, anti-cancer, lipid-lowering and immune-improving effects by up-regulating or down-regulating genes related to antioxidant, anti-cancer, lipid-lowering and immunity. Furthermore, lycopene is natural, pollution-free, and has no toxic side effects. The application of lycopene in animal production has shown that it could improve livestock production performance, slaughter performance, immunity, antioxidant capacity, intestinal health, and meat quality. Therefore, lycopene as a new type of feed additive, has broader application prospects in many antibiotic-forbidden environments. This article serves as a reference for the use of lycopene as a health feed additive in animal production by going over its physical and chemical characteristics, antioxidant, lipid-lowering, anti-cancer, and application in animal production.

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Lycopene improves maternal reproductive performance by modulating milk composition and placental antioxidative and immune status

Abstract: Placental health and milk quality are important for maternal reproductive performance during pregnancy and lactation.

Cited by 9 publications

References 74 publications

Taxifolin increased semen quality of Duroc boars by improving gut microbes and blood metabolites

Taxifolin increased semen quality of Duroc boars by improving gut microbes and blood metabolites

The sources, properties, extraction, biosynthesis, pharmacology, and application of lycopene

Physicochemical properties, mechanism of action of lycopene and its application in poultry and ruminant production

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