Lycopene exerts anti-inflammatory effect to inhibit prostate cancer progression

Jiang, Lining; Liu, Ya-Bin

doi:10.4103/aja.aja_70_18

Cited by 41 publications

(20 citation statements)

References 34 publications

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“…In addition, it activates kinases that release and translocate Nrf2 to the nucleus [50, 52]. The anti-inflammatory action of lycopene can be attributed mainly to the induction of inflammatory mediators, such as interleukin-1 β (IL-1 β ), IL-6, IL-8, and tumor necrosis factor- α (TNF- α ) [53].…”

Section: Discussionmentioning

confidence: 99%

Antioxidants as Adjuvants in Periodontitis Treatment: A Systematic Review and Meta-Analysis

Castro

Duarte

Nascimento

et al. 2019

Oxidative Medicine and Cellular Longevity

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This systematic review with meta-analysis aimed to evaluate the effect of antioxidants as an adjuvant in periodontitis treatment. The following databases were consulted: PubMed, Scopus, Web of Science, Cochrane, Lilacs, OpenGrey, and Google Scholar. Based on the PICO strategy, the inclusion criteria comprised interventional studies including periodontitis patients (participants) treated with conventional therapy and antioxidants (intervention) compared to patients treated only with conventional therapy (control) where the periodontal response (outcome) was evaluated. The risk of bias was evaluated using the Cochrane RoB tool (for randomized studies) and ROBINS-I tool (for nonrandomized studies). Quantitative data were analyzed in five random effects meta-analyses considering the following periodontal parameters: clinical attachment loss (CAL), plaque index (PI), gingival index (GI), bleeding on probing (BOP), and probing depth (PD). After all, the level of certainty was measured with the Grading of Recommendation, Assessment, Development, and Evaluation (GRADE) tool. Among the 1884 studies identified, only 15 interventional studies were according to the eligibility criteria and they were included in our review. From them, 4 articles presented a high risk of bias. The meta-analysis showed a statistically significant difference for CAL (SMD 0.29 (0.04, 0.55), p=0.03, I2=13%), PI (SMD 0.41 (0.18, 0.64), p=0.0005, I2=47%), and BOP (SMD 0.55 (0.27, 0.83), p=0.0001, I2=0%). The GRADE tool showed a moderate to high certainty in the quality of evidence depending on the clinical parameter and antioxidants used. These results suggest that the use of antioxidants is an adjunct approach to nonsurgical periodontal therapy which may be helpful in controlling the periodontal status.

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Section: Discussionmentioning

confidence: 99%

Antioxidants as Adjuvants in Periodontitis Treatment: A Systematic Review and Meta-Analysis

Castro

Duarte

Nascimento

et al. 2019

Oxidative Medicine and Cellular Longevity

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“…One of the most well-known anticancer agents with anti-oxidant and anti-inflammatory properties is lycopene that exerts therapeutic effects on a large variety of cancers [150, 151]. In particular, it has been demonstrated that lycopene intake reduces prostate cancer risk [152].…”

Section: Natural Compounds As Anti-cancer Agentsmentioning

confidence: 99%

Beneficial Role of Phytochemicals on Oxidative Stress and Age-Related Diseases

Forni

Facchiano

Bartoli

et al. 2019

BioMed Research International

369

219

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Aging is related to a number of functional and morphological changes leading to progressive decline of the biological functions of an organism. Reactive Oxygen Species (ROS), released by several endogenous and exogenous processes, may cause important oxidative damage to DNA, proteins, and lipids, leading to important cellular dysfunctions. The imbalance between ROS production and antioxidant defenses brings to oxidative stress conditions and, related to accumulation of ROS, aging-associated diseases. The purpose of this review is to provide an overview of the most relevant data reported in literature on the natural compounds, mainly phytochemicals, with antioxidant activity and their potential protective effects on age-related diseases such as metabolic syndrome, diabetes, cardiovascular disease, cancer, neurodegenerative disease, and chronic inflammation, and possibly lower side effects, when compared to other drugs.

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“…One of the main mechanisms that has been proposed to explain the favorable effect of tomato intake on cancer prevention involves lycopene, which are found in high amounts in tomato products ( 31 ). A recent study indicated that lycopene is a promising chemotherapy drug by inhibiting prostate cancer progression via the inflammatory response signaling ( 32 ). Wang et al ( 33 ) found that dietary lycopene consumption and its blood level were all associated with the risk of prostate cancer based on a systematic review and dose-response meta-analysis.…”

Section: Discussionmentioning

confidence: 99%

Dietary Tomato Consumption and the Risk of Prostate Cancer: A Meta-Analysis

Luo

2021

Front. Nutr.

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Objective: Several epidemiological studies have linked tomato products consumption with prostate cancer risk; however, the findings yielded inconsistent results. The aim of the present meta-analysis is to summary the evidence on this association based on eligible cohort studies.Materials and Methods: A comprehensive literature search of articles was performed in March 2021 using PubMed, ISI Web of Science, and Scopus databases. A random-effects model was used to calculate the combined relative risks (RRs) and their corresponding 95% confidence intervals (CIs). Heterogeneity across studies was assessed using Cochran's Q statistic and the I2 score.Results: A total of 10 prospective studies were finally included in our meta-analysis. There was no evidence of a significant association between tomato products consumption and prostate cancer risk (RR 0.91, 95% CI 0.79–1.03, P = 0.138). Subgroup meta-analyses were performed by tomato types, geographical region, publication year, study quality and number of cases. No significant associations were observed in any subgroups (all P > 0.05). No significant publication bias was observed using Begg's test (P = 0.602) or Egger's test (P = 0.957).Conclusion: The results of this meta-analysis indicated that tomato consumption was not related with the risk of prostate cancer. Further prospective large-scale cohort studies are still warranted to verify our findings.

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Lycopene exerts anti-inflammatory effect to inhibit prostate cancer progression

Cited by 41 publications

References 34 publications

Antioxidants as Adjuvants in Periodontitis Treatment: A Systematic Review and Meta-Analysis

Antioxidants as Adjuvants in Periodontitis Treatment: A Systematic Review and Meta-Analysis

Beneficial Role of Phytochemicals on Oxidative Stress and Age-Related Diseases

Dietary Tomato Consumption and the Risk of Prostate Cancer: A Meta-Analysis

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