Lycopene bioavailability and metabolism in humans: an accelerator mass spectrometry study

Abstract

Lycopene was extensively isomerized after dosing and rapidly metabolized into polar metabolites excreted into urine with the rapid peak of (14)CO(2) after dosing, which implies that β-oxidation was involved in the lycopene metabolism. Lycopene or its metabolites were detected in skin for up to 42 d.

Differential Bioavailability, Clearance, and Tissue Distribution of the Acyclic Tomato Carotenoids Lycopene and Phytoene in Mongolian Gerbils

“…1 replaced metabolic losses but did not increase LYC concentrations. Evidence of extensive LYC metabolism in our model is supported by a recent report in which the 18.6-d plasma half-life of total radioactivity (from 14 C-LYC and 14 C-LYC metabolic products) in 2 men after consuming a microdose of 14 C-LYC was substantially longer than the 5-d plasma half-life of 14 C-LYC (47). Furthermore, the maximal serum concentration of total radioactivity in these men was 2.6-fold greater than the maximal serum concentration of radioactivity from 14 C-LYC (47).…”

Recent trends in the development of nanophytobioactive compounds and delivery systems for their possible role in reducing oxidative stress in Parkinson’s disease models

“…208 However, bioavailability in the gastrointestinal tract was limited after oral administration. 212 Nanosizing lycopene using a self-emulsifying nanodelivery system or nanoemulsion greatly enhances bioavailability of the lycopene. [212][213][214] Nanosized lycopene prepared using a nanoemulsion delivery technique with a size of 100 nm enhances in vitro antioxidant activity 213 with increased bioaccessibility.…”

“…212 Nanosizing lycopene using a self-emulsifying nanodelivery system or nanoemulsion greatly enhances bioavailability of the lycopene. [212][213][214] Nanosized lycopene prepared using a nanoemulsion delivery technique with a size of 100 nm enhances in vitro antioxidant activity 213 with increased bioaccessibility. Nanolycopene developed using a nanostructured lipid carrier delivery technique with a size of 150-160 nm shows less degradation and enhanced in vitro antioxidant activity.…”

Lycopene Estimation in Tomato Lines Using Infrared Absorbance and Tomato Analyzer

“…However, human plasma can hold high amounts of lycopene (Ross et al, 2011;Shi and Le Maguer, 2000). Increasing the lycopene content in fresh market tomatoes could offset decreased availability of lycopene.…”