Lycopene as a chemopreventive agent in the treatment of high-grade prostate intraepithelial neoplasia

Mohanty, N.; Saxena, Sunita; Singh, Uday Pratap; Goyal, Neeraj Krishna; Arora, Renu

doi:10.1016/j.urolonc.2005.05.012

Cited by 97 publications

(46 citation statements)

References 9 publications

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“…Therefore, exploration of novel modalities as well as anticancer agents is important. In this regard, many nutritive and nonnutritive phytochemicals with diverse [35][36][37] In this study, we investigated the potential anticancer effects of substances presented in a variety of C comatus strains on LNCaP prostate cancer cell lines. Previous results obtained by Zaidman et al 26 showed that E extract prepared from C comatus strain 97 was able to inhibit AR activity in LNCaP cell lines.…”

Section: Discussionmentioning

confidence: 99%

The Culinary-Medicinal Mushroom Coprinus comatus as a Natural Antiandrogenic Modulator

2010

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Prostate cancer is the most common cancer diagnosed in men. Chemotherapy, androgen ablation, and androgen antagonist treatments have proven to have significant effects in the early stages of prostate cancer, whereas advanced prostate cancer is resilient to such treatments. The androgen receptor (AR), a ligand-dependent transcription factor, is the major drug target of prostate cancer therapy. Transition to the androgen-independent stage involves the activation of signaling pathways, AR gene mutations, and other mechanisms. Higher basidiomycetes mushrooms have been used since ancient times in folk medicine to treat a diversity of diseases, including cancer. The present study evaluates the antiandrogenic activity of different Coprinus comatus strains in their ability to interfere with AR function. The authors found that the most active extract was C comatus strain 734 extracted with hexane (CC734-H). This extract was able to (1) inhibit AR-mediated reporter activity, (2) inhibit the proliferation and viability of the LNCaP cell line, and (3) inhibit the colony formation of the LNCaP cell line, in comparison to the DU-145, PC-3, and MDA-Kb2 cells. In addition, CC734-H was able to reduce AR levels and prostate-specific antigen gene expression in the LNCaP-treated cell line. This study illustrates the potential of the C comatus mushroom as a natural antiandrogenic modulator that could serve in the treatment of prostatic diseases.

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Section: Discussionmentioning

confidence: 99%

The Culinary-Medicinal Mushroom Coprinus comatus as a Natural Antiandrogenic Modulator

2010

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“…13 While being widely investigated in observational research, only a few small RCTs have looked at lycopene supplements versus placebo, and these did not show significant results. 14,15 Polyphenols are natural, water-soluble compounds and are the main constituents of tea. Content varies, depending on species and growing conditions of the plants.…”

Section: Lycopene and Polyphenolsmentioning

confidence: 99%

Dietary supplements and prostate cancer prevention

Marra

Oderda

2016

Trends Urol & Men's Health

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Prevention of prostate cancer through the use of dietary supplements is an attractive proposition for patients and doctors. Many patients already turn to supplements, but doctors are not sure what to say when asked for an opinion on their potential benefits. In this article, the authors take a critical look at the evidence for supplements in prostate cancer and find that, in general, the evidence is wanting.

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“…It is an excellent source of vitamin C. Red-fleshed watermelon contains significant amounts of lycopene, a carotenoid pigment, which is a highly efficient free radical scavenger (Perkins-Veazie et al 2006). High dietary lycopene consumption (4 mg or more/day) may be beneficial in reducing the incidence of prostate and oral cancers and in the prevention of oxidative damage to the cells (Mohanty et al 2006;Zhao et al 2006;Mayne et al 2004). Tomatoes and tomato products provide most of the dietary intake of lycopene in Western diets.…”

Section: Introductionmentioning

confidence: 99%

Micropropagation of an elite F1 watermelon (Citrullus lanatus) hybrid from the shoot tip of field grown plants

Khalekuzzaman

Khatun²,

Rashid³

et al. 2012

Braz. arch. biol. technol.

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Lycopene as a chemopreventive agent in the treatment of high-grade prostate intraepithelial neoplasia

Cited by 97 publications

References 9 publications

The Culinary-Medicinal Mushroom Coprinus comatus as a Natural Antiandrogenic Modulator

The Culinary-Medicinal Mushroom Coprinus comatus as a Natural Antiandrogenic Modulator

Dietary supplements and prostate cancer prevention

Micropropagation of an elite F1 watermelon (Citrullus lanatus) hybrid from the shoot tip of field grown plants

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