Lycopene: An antioxidant and radioprotector against γ-radiation-induced cellular damages in cultured human lymphocytes

In vivo Time-Dependent Radio-Protective Effect of Lycopene Against Whole-Body Gamma Radiation in Mice

“…In Srinivasan et al µg/mL) significantly decreased the frequency of cellular changes and increased the previously reduced glutathione levels compared with the gamma-radiated control group with no lycopene pre-treatment (23). The dose of 5 µg/mL of lycopene was found to be more effective than the other two doses (23). Consistent with the mentioned studies, we also demonstrated that pre-treatment with lycopene could offer protection of normal lymphocytes against gammaradiation-induced cellular damage.…”

“…Other studies also reported similar in vitro protection effects of lycopene. In Srinivasan et al µg/mL) significantly decreased the frequency of cellular changes and increased the previously reduced glutathione levels compared with the gamma-radiated control group with no lycopene pre-treatment (23). The dose of 5 µg/mL of lycopene was found to be more effective than the other two doses (23).…”

Structural Studies on the Radio-Protective Effect of Lycopene (Tomato Supplementation) Against Hepatic Cellular Injury Induced by Chronic Doses of Gamma Radiation

“…These were in accordance with studies which come to the fact that the imbalance in antioxidant status in the cells as a result of ionizing may be ameliorated as result of administration of Lycopene [20]. Lycopene significantly restored the antioxidant enzymes Superoxide Dismutase (SOD), Glutathione Peroxidase (GSHPx), and Glutathione Reductase (GR); Reduced Glutathione (GSH); and decreased levels of the lipid peroxide Malondialdehyde (MDA) in hypertensive patients [21]. Lycopene was found to have a favorable effect in reducing MDA levels and increasing GSH levels in coronary artery disease in postmenopausal women [22].…”

“…Other interesting finding in this study was that lipid droplets still found in Lycopene treated animals in considerable averages compared to γ-irradiated rats [28]. This is may be due to the antioxidant sparing action of Lycopene in decreasing lipid peroxidation and improved antioxidant status preventing the damage to the cell [21].…”

“…The nucleus, mitochondria get its normality [25,26]. These results run barrel with Srinivasan [21], who showed that pretreatment with Lycopene offers protection to normal lymphocytes against γ-radiation-induced cellular damage due to free radical released by radiation reaction inside the cell. The ameliorative effect of Lycopene may be resulted from; it acts as a scavenger to the free radicals that causes damage to the cells and tissues.…”