Lycopene ameliorates diabetic osteoporosis via anti-inflammatory, anti-oxidation, and increasing Osteoprotegerin/RANKL expression ratio

Qi, Shan; Shao, Meng Li; Sun, Ze; Chen, Si Min; Hu, Ying; Wang, Hong Tao; Wei, Tian; Li, Xing Sheng; Zheng, Hong

doi:10.1016/j.jff.2021.104539

Cited by 16 publications

(14 citation statements)

References 49 publications

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“…Diabetes Induction in SD Rats, Animal Grouping, and Treatment After 7 days of acclimatization, except for 10 animals in the control group, the remaining animals were intraperitoneally injected with 45 mg/kg of STZ after fasting overnight, and the dosage of STZ was based on our previous study (16,17); STZ was dissolved in citric acid buffer solution at pH 4.3, and 10 animals in the control group were injected with citric acid buffer solution. After 72 h, animal's blood glucose was detected, and animals with blood glucose higher than 11.1 mmol/L were selected for subsequent experiments.…”

Section: Animalsmentioning

confidence: 99%

Chondroitin Sulfate Alleviates Diabetic Osteoporosis and Repairs Bone Microstructure via Anti-Oxidation, Anti-Inflammation, and Regulating Bone Metabolism

Shao

Sun

et al. 2021

Front. Endocrinol.

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Diabetic osteoporosis (DOP) belongs to secondary osteoporosis caused by diabetes; it has the characteristics of high morbidity and high disability. In the present study, we constructed a type 1 diabetic rat model and administered chondroitin sulfate (200 mg/kg) for 10 weeks to observe the preventive effect of chondroitin sulfate on the bone loss of diabetic rats. The results showed that chondroitin sulfate can reduce blood glucose and relieve symptoms of diabetic rats; in addition, it can significantly increase the bone mineral density, improve bone microstructure, and reduce bone marrow adipocyte number in diabetic rats; after 10 weeks of chondroitin sulfate administration, the SOD activity level was upregulated, as well as CAT levels, indicating that chondroitin sulfate can alleviate oxidative stress in diabetic rats. Chondroitin sulfate was also found to reduce the level of serum inflammatory cytokines (TNF-α, IL-1, IL-6, and MCP-1) and alleviate the inflammation in diabetic rats; bone metabolism marker detection results showed that chondroitin sulfate can reduce bone turnover in diabetic rats (decreased RANKL, CTX-1, ALP, and TRACP 5b levels were observed after 10 weeks of chondroitin sulfate administration). At the same time, the bone OPG and RUNX 2 expression levels were higher after chondroitin sulfate treatment, the bone RANKL expression was lowered, and the OPG/RANKL ratio was upregulated. All of the above indicated that chondroitin sulfate could prevent STZ-induced DOP and repair bone microstructure; the main mechanism was through anti-oxidation, anti-inflammatory, and regulating bone metabolism. Chondroitin sulfate could be used to develop anti-DOP functional foods and diet interventions for diabetes.

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Section: Animalsmentioning

confidence: 99%

Chondroitin Sulfate Alleviates Diabetic Osteoporosis and Repairs Bone Microstructure via Anti-Oxidation, Anti-Inflammation, and Regulating Bone Metabolism

Shao

Sun

et al. 2021

Front. Endocrinol.

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“…Therefore, the number of trabeculae and microstructure play a crucial role in increasing the strength of the cancellous bone. 49,59…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, the number of trabeculae and microstructure play a crucial role in increasing the strength of the cancellous bone. 49,59 In this study, micro-CT was used to reconstruct the femoral backbone and trabeculae of each group of mice in three dimensions, and then to quantify the morphological parameters of the femur. Fig.…”

Section: D and 3d Images Of The Cancellous Bone Of The Femur With Mic...mentioning

confidence: 99%

Preparation of synbiotic milk powder and its effect on calcium absorption and the bone microstructure in calcium deficient mice

et al. 2023

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“…The levels of proinflammatory cytokines (IL-1 β ) are exceptionally high in conditions of diabetes-associated complications [ 31 , 32 ]. Administration of T. stans extracts at 200 mg/kg, 300 mg/kg, and the highest dose, i.e., 400 mg/kg, along with the standard treatment Gabapentin showed a significant decrease in the levels of VEGF in comparison to the disease control group.…”

Section: Resultsmentioning

confidence: 99%

Elucidating the Neuroprotective Effect of Tecoma stans Leaf Extract in STZ-Induced Diabetic Neuropathy

Gupta

Behl

Sehgal

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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Background. Diabetes is considered one of the most encyclopedic metabolic disorders owing to an alarming rise in the number of patients, which is increasing at an exponential rate. With the current therapeutics, which only aims to provide symptomatic and momentary relief, the scientists are shifting gears to explore alternative therapies which not only can target diabetes but can also help in limiting the progression of diabetic complications including diabetic neuropathy (DN). Methods. Tecoma stans leaf methanolic extract was prepared using the Soxhlet method. A streptozotocin (STZ; 45 mg/kg)-induced diabetic animal model was used and treatment with oral dosing of T. stans leaf extract at the different doses of 200 mg/kg, 300 mg/kg, and highest dose, i.e., 400 mg/kg, was initiated on day 3 after STZ administration. The pharmacological response for general and biochemical (angiogenic, inflammatory, and oxidative) parameters and behavioral parameters were compared using Gabapentin as a standard drug with the results from the test drug. Results. Parameters associated with the pathogenesis of diabetic neuropathy were evaluated. For general parameters, different doses of T. stans extract (TSE) on blood sugar showed significant effects as compared to the diabetic group. Also, the results from biochemical analysis and behavioral parameters showed significant positive effects in line with general parameters. The combination therapy of TSE at 400 mg/kg with a standard drug produced nonsignificant effects in comparison with the normal group. Conclusion. The leaves of T. stans possess antidiabetic effects along with promising effects in the management of DN by producing significant effects by exhibiting antioxidative, antiangiogenic, and anti-inflammatory properties, which are prognostic markers for DN, and thus, T. stans can be considered as an emerging therapeutic option for DN.

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Lycopene ameliorates diabetic osteoporosis via anti-inflammatory, anti-oxidation, and increasing Osteoprotegerin/RANKL expression ratio

Cited by 16 publications

References 49 publications

Chondroitin Sulfate Alleviates Diabetic Osteoporosis and Repairs Bone Microstructure via Anti-Oxidation, Anti-Inflammation, and Regulating Bone Metabolism

Chondroitin Sulfate Alleviates Diabetic Osteoporosis and Repairs Bone Microstructure via Anti-Oxidation, Anti-Inflammation, and Regulating Bone Metabolism

Preparation of synbiotic milk powder and its effect on calcium absorption and the bone microstructure in calcium deficient mice

Elucidating the Neuroprotective Effect of Tecoma stans Leaf Extract in STZ-Induced Diabetic Neuropathy

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