Lycopene alleviates AFB₁-induced immunosuppression by inhibiting oxidative stress and apoptosis in the spleen of mice

Abstract

Lycopene alleviates AFB1-induced immunosuppression by inhibiting oxidative stress and mitochondria-mediated apoptosis in the spleen of mice.

Antioxidant Effect of Soymilk Fermented by Lactobacillus plantarum HFY01 on D-Galactose-Induced Premature Aging Mouse Model

“…The spleen can recover and store the iron used to make new red blood cells, which can be quickly replenished and released by the human body in a state of blood loss. The spleen also plays an important role in filtering harmful bacteria in the blood and managing and regulating blood volume (31). Oxidative damage of the skin is a key sign of aging.…”

Aflatoxins as a risk factor for liver cirrhosis: a systematic review and meta-analysis

“…), per hydroxyl radical (HOO − ) and superoxide anion [29,33]. This can result in oxidative stress owing to an imbalance between limited antioxidant defenses and the excessive formation of ROS, resulting in the damage of biological molecules including lipids, proteins, and DNA in cellular systems [34,35]. In support of this hypothesis, several studies have demonstrated the potential for antioxidants to lower the risk of hepatotoxicity caused by exposure to the AF [29,[36][37][38][39].…”

“…Moreover, many studies have reported the pivotal role of oxidative stress induced by AF in eliciting programmed cell death or apoptosis through mitochondrial signaling pathways [25,[40][41][42]. ROS induced mitochondrial damage is known to cause uncoupling of mitochondrial oxidative phosphorylation and the associated reduction in mitochondrial membrane potential following AFB1 administration in vivo and in vitro [25,33,35]. Consequently, mitochondrial alterations cause activation of cytochrome C that modulates Bcl2/Bax gene expression and activate caspase 9 and caspase 3, which results in cell death [41].…”

Protective effect of vitamin C and lycopene on the in vitro fertilization capacity of sex‐sorted bull sperm by inhibiting the oxidative stress

“…Lyc supplementation inhibits LPO during cryopreservation of rabbit sperm (Rosato et al, 2012) and reduces MDA levels in bull sperms (Tvrdá et al, 2016) and mouse spleen (Xu et al, 2019).…”