Lycibarbarspermidine L from the fruit of Lycium barbarum L. recovers intestinal barrier damage via regulating miR-195-3p

Zhang, Xueni; Wen, Xiaoyan; Zhou, Di; Liang, Yuhang; Zhou, Zhengqun; Chen, Gang; Li, Wei; Gao, Hao; Li, Ning

doi:10.1016/j.jep.2023.117419

Cited by 2 publications

(1 citation statement)

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“…On the other hand, LRM has black fruits and contains more anthocyanins, tannins, and phenolics [ 11 ], which may potentially lead to stronger antioxidant effects. The main components of these berries include polysaccharides (like Lycium barbarum polysaccharides (LBPs), generally consisting of six monosaccharides, including galactose, glucose, rhamnose, arabinose, mannose, and xylose) [ 12 , 13 ], betaine, and other compounds [ 14 , 15 ]. Red-fruited goji berries are rich in carotenoid components like Zeaxanthin, β-Carotene, and Lutein, while black-fruited goji berries contain higher levels of anthocyanin-like components and unique components such as lyrium spermidine A ( Figure 1 ) [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

The Medicinal Species of the Lycium Genus (Goji Berries) in East Asia: A Review of Its Effect on Cell Signal Transduction Pathways

Jiang,

Chen,

Liao

et al. 2024

Plants

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Natural plants contain numerous chemical compounds that are beneficial to human health. The berries from the Lycium genus are widely consumed and are highly nutritious. Moreover, their chemical constituents have attracted attention for their health-promoting properties. In East Asia, there are three varieties of the Lycium genus (Lycium barbarum L., Lycium chinense Miller, and L. ruthenicum Murray) that possess medicinal value and are commonly used for treating chronic diseases and improving metabolic disorders. These varieties are locally referred to as “red Goji berries” or “black Goji berries” due to their distinct colors, and they differ in their chemical compositions, primarily in terms of carotenoid and anthocyanin content. The pharmacological functions of these berries include anti-aging, antioxidant, anti-inflammatory, and anti-exercise fatigue effects. This review aims to analyze previous and recent studies on the active ingredients and pharmacological activities of these Lycium varieties, elucidating their signaling pathways and assessing their impact on the gut microbiota. Furthermore, the potential prospects for using these active ingredients in the treatment of COVID-19 are evaluated. This review explores the potential targets of these Lycium varieties in the treatment of relevant diseases, highlighting their potential value in drug development.

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